Öz
Kaynakça
- Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.
Öz
Hypertension, defined
as high blood pressure, is a common medical condition leading to cardiovascular
disability and premature deaths. Blood pressure control in an efficient way are
assumed to the main targets to prevent hypertension. Since conventional dosage
forms (e.g. immediate release tablets, capsules, etc.) show some limitation, greater
attention is being paid on designing the modified drug release systems.
Modified release is defined as drug releasing from dosage form some time after
the administration or in prolonged period of time. In this study, we aimed to
design metoprolol tartarate loaded chitosan microparticles to obtained modified
drug release. Chitosan microparticles produced via ionic gelation with
tripolyphosphate as a crosslinking agent. Prepared formulations were characterized
and metoprolol tartarate was loaded into the optimal blank microspheres. The
entrapment efficiency, drug loading, cell viability assay and in vitro drug release were investigated.
Optimum formulation was spherical and had 81% of yield and 75.373±7.384µm
particle size. 16 mg of metoprolol tartarate could be loaded into
microparticles and drug release could be maintained for 48 hours.
Anahtar Kelimeler
chitosan metoprolol tartarate controlled release microparticles
Kaynakça
- Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Temel Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Aralık 2018 |
| Kabul Tarihi | 23 Aralık 2018 |
| Yayımlandığı Sayı | Yıl 2018 |