A preliminary report of relationship between abortion and Q fever in Central Black Sea Region Turkish woman
Öz
Abstract
Aim. Q fever, which is a zoonosis caused by Coxiella burnetii, may result in abortions in infected animals and pregnant women. In our study, we searched the association between Q fever serology and abortion in a region where Q fever is endemic. Method. This study was conducted in Gaziosmanpaşa University Hospital between March and May 2012. A total of 100 women, from these, 64 had a history of spontaneus abortion (cases) and 36 had live births with no complicated obstetrics history or complicated partum (controls), enrolled in the study. Both groups were compared according to where they live, underlying diseases, contact with farm animals or pets and village connectivity. Results. IgG seroprevalence of Coxiella in our study group with the history of abortion was 15.6%, and 11.1% in the control group (p>0.05). When case and control groups were compared, the frequency of inhabitants of the village (p=0.012), subjects who had contact with farm animals [p=0.026, especially cattle (p=0.013)] or domestic animals (p=0.018) in case group were more common than the control group. When all the samples were analyzed, it was seen that the only significant variable affecting Coxiella IgG seropositivity was residency in rural area or visiting rural area (p=0.018). Conclusions. We have found that the relation between abortion and Q fever infection was not statistically significant. On this issue, multicenter studies which have the higher number of samples are needed in our country.
Keywords: Q fever, spontaneous abortions, endemic region
Özet
Amaç. Q ateşi Coxiella burnetii tarafından oluşturulan bir zoonozdur. Q ateşi gebe hayvanlarda ve gebe kadınlarda abortusa neden olabilir. Biz bu çalışmamızda Q ateşi için endemik bir bölgede Q ateşi seropozitifliği ve abortus arasındaki ilişkiyi araştırdık. Yöntem. Bu çalışma Gaziosmanpaşa Üniversitesi Hastanesinde Mart 2012-Mayıs 2012 tarihleri arasında yürütüldü. Çalışmaya 18 yaş üzerinde toplam 100 kadın dahil edildi. Bunların 64’ünün spontan abortus hikayesi pozitif (vaka grubu) iken 36’sının hiç komplikasyonlu gebelik veya doğum hikayesi yoktu (kontrol grubu). Her iki grup yaşadıkları yer, altta yatan hastalıkları, çiflik hayvanı veya evcil hayvanlarla temas ve köy yaşantısı ile ilişki açısından karşılaştırıldı. Bulgular. Vaka grubunda Coxiella lgG seropozitifliği %15,6 çıkarken kontrol grubunda %11,1 olarak saptandı, bu fark istatistiksel olarak anlamlı değildi (p>0,05). Vaka grubu kontrol grubuyla karşılaştırıldığında köyde yaşama (p=0,012), çiftlik hayvanları ile temas [p=0,026; özellikle koyun (p=0,013)] veya evcil hayvanlarla temas (p=0,018) vaka grubunda anlamlı derecede daha yüksek saptandı. Tüm örnekler analiz edildiğinde Coxiella IgG seropozitifliğini etkileyen en önemli değişken kırsal alanda yaşama veya kırsal yaşamla ilişkili olma olarak bulundu (p=0,018). Sonuç. Çalışmanın sonucunda Q ateşi ile abortus arasında anlamlı bir ilişki bulunamadı. Bu çalışma bu konuyla ilgili ülkemizde yapılmış ilk çalışma olmakla birlikte çok merkezli ve yüksek örneklem sayılı çalışmalara ihtiyaç vardır.
Anahtar sözcükler: Q ateşi, spontan abortus, endemik hastalık
Anahtar Kelimeler
Kaynakça
- Madariaga MG, Rezai K, Trenholme GM, Weinstein RA. Q fever: A biological weapon in your backyard. Lancet Infect Dis 2000; 3: 709-21.
- Maurin M. Raoult Q fever. Clin. Microbiol Rev 1999; 12: 518-3.
- Gikas A, Kokkini S, Tsioutis C. Q fever: Clinical manifestations and treatment. Expert Rev Anti Infect Ther 2010; 8: 529-39.
- Rey D, Obadia Y, Tissot-Dupont H, Raoult D. Seroprevalence of antibodies to Coxiella burnetti among pregnant women in South Eastern France. Eur J Obstet Gynecol Reprod Biol 2000; 93: 151-6.
- Syrucek L, Sobeslavsky O, Gutvirth I. Isolation of Coxiella burnetii from human placentas. J Hyg Epidemiol Microbiol Immunol 1958; 2: 29-35.
- Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A. Managing Q fever during pregnancy: The benefits of long-term cotrimoxazole therapy. Clin Infect Dis 2007; 45: 548-55.
- Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A. Q fever during pregnancy: A cause of poor fetal and maternal outcome. Ann NY Acad Sci 2009; 1166: 79
- Quijada SG, Terán BM, Murias PS, Anitua AA, Cermeño JL, Frías AB. Q fever and spontaneous abortion. Clin Microbiol Infect 2012; 18: 533-8.
- Tissot-Dupont H, Vaillant V, Rey S, Raoult D. Role of sex, age, previous valve lesion, and pregnancy in the clinical expression and outcome of Q fever after a large outbreak. Clin Infect Dis 2007; 44: 232-7.
- Kilic S, Yilmaz GR, Komiya T, Kurtoglu Y, Karakoc EA. Prevalence of Coxiella burnetii antibodies in blood donors in Ankara, Central Anatolia, Turkey New Microbiol 2008; 31; 527-34.
- Payzın S. Epidemiological investigations on Q fever in Turkey. Bull World Health Organ 1953; 9: 553-8.
- Golem SB. La Q flevre en Turquie: l’epidemiologie et une revue sommaire sur la flevre Q des animaux (Q feverepidemiology and information on Q fever infection among animals in Turkey).Turkish Bull Hyg Exp Biol 1951; 11: 1-21.
- Gozalan A, Rolain JM, Ertek M, EAngelakis E, Coplu N, Basbulut EA, Korhasan BB, Esen B. Seroprevalence of Q fever in a district located in the west Black Sea Region of Turkey. Eur J Clin Microbiol Infect Dis 2010; 29: 465-9.
- Berberoğlu A, Gözalan S, Kılıç S, Kurtoğlu D, Esen B. A Seroprevalance of Coxiella Burnetii in Antalya, Diyarbakır and Samsun Provinces. Microbiol Bul 2004; 38: 385-91.
- Vaidya VM, Malik SV, Kaur S, Kumar S, Barbuddhe SB. Comparison of PCR, immunofluorescence assay, and pathogen isolation for diagnosis of Q fever in humans with spontaneous abortions. J Clin Microbiol 2008; 46: 2038-44.
- Baud D, Peter O, Langel C, Regan L, Greub G. Seroprevalence of Coxiella burnetii and Brucella abortus among pregnant women. Clin Microbiol Infect 2009; 15: 499-501.
- Stein A, Raoult D. Q fever during pregnancy: A Public Health Problem in Southern France Clinical Infectious Diseases 1998; 27: 592-6.
- Nielsen SY, Hjİllund NH, Andersen AM, Henriksen TB, Kantsİ B, Krogfelt KA. Presence of antibodies against Coxiella burnetii and risk of spontaneous abortion: a nested case-control study. PLoS One 2012; 7: 31909.
- Van der Hoek W, Meekelenkamp JC, Leenders AC, Wijers N, Notermans DW, Hukkelhoven CW. Antibodies against coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Nedherlands. BMC Infect Dis 2011; 11: 44.
- Raoult D, Fenollar F, Stein A. Q fever during pregnancy: Diagnosis, treatment, and follow-up. Arch Intern Med 2002; 162: 701-4.
A PRELIMINARY REPORT OF RELATIONSHIP BETWEEN ABORTION AND Q FEVER IN CENTRAL BLACK SEA REGION TURKISH WOMAN
Öz
Objectives: Q fever, which is a zoonosis caused by Coxiella burnetii, may result in abortions in infected animals and pregnant women. In our study, we searched the association between Q fever serology and abortion in a region where Q fever is endemic.
Material and Methods: This study was conducted in Gaziosmanpasa University Hospital (Tokat, Turkey) between March and May 2012. A total of 100 women, from these, 64 had a history of spontaneus abortion (cases) and 36 had live births with no complicated obstetrics history or complicated partum (controls), enrolled in the study. Both groups were compared according to where they live, underlying diseases, contact with farm animals or pets and village connectivity.
Results: While IgG seroprevalence of Coxiella in our study group with the history of abortion was 15.6%, it was 11.1% in the control group (p>0,05). When case and control groups were compared, we found that the frequency of inhabitants of the village (p=0.012), subjects who had contact with farm animals (p = 0.026, especially cattle (p=0.013)) or domestic animals (p=0.018) in case group were more common than the control group. When all the samples were analyzed, it was seen that the only significant variable affecting Coxiella IgG seropositivity was residency in rural area or visiting rural area (p=0.018).
Conclusions: We have found that the relation between abortion and Q fever infection was not statistically significant. On this issue, multicenter studies which have the higher number of samples are needed in our country.
Anahtar Kelimeler
Kaynakça
- Madariaga MG, Rezai K, Trenholme GM, Weinstein RA. Q fever: A biological weapon in your backyard. Lancet Infect Dis 2000; 3: 709-21.
- Maurin M. Raoult Q fever. Clin. Microbiol Rev 1999; 12: 518-3.
- Gikas A, Kokkini S, Tsioutis C. Q fever: Clinical manifestations and treatment. Expert Rev Anti Infect Ther 2010; 8: 529-39.
- Rey D, Obadia Y, Tissot-Dupont H, Raoult D. Seroprevalence of antibodies to Coxiella burnetti among pregnant women in South Eastern France. Eur J Obstet Gynecol Reprod Biol 2000; 93: 151-6.
- Syrucek L, Sobeslavsky O, Gutvirth I. Isolation of Coxiella burnetii from human placentas. J Hyg Epidemiol Microbiol Immunol 1958; 2: 29-35.
- Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A. Managing Q fever during pregnancy: The benefits of long-term cotrimoxazole therapy. Clin Infect Dis 2007; 45: 548-55.
- Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A. Q fever during pregnancy: A cause of poor fetal and maternal outcome. Ann NY Acad Sci 2009; 1166: 79
- Quijada SG, Terán BM, Murias PS, Anitua AA, Cermeño JL, Frías AB. Q fever and spontaneous abortion. Clin Microbiol Infect 2012; 18: 533-8.
- Tissot-Dupont H, Vaillant V, Rey S, Raoult D. Role of sex, age, previous valve lesion, and pregnancy in the clinical expression and outcome of Q fever after a large outbreak. Clin Infect Dis 2007; 44: 232-7.
- Kilic S, Yilmaz GR, Komiya T, Kurtoglu Y, Karakoc EA. Prevalence of Coxiella burnetii antibodies in blood donors in Ankara, Central Anatolia, Turkey New Microbiol 2008; 31; 527-34.
- Payzın S. Epidemiological investigations on Q fever in Turkey. Bull World Health Organ 1953; 9: 553-8.
- Golem SB. La Q flevre en Turquie: l’epidemiologie et une revue sommaire sur la flevre Q des animaux (Q feverepidemiology and information on Q fever infection among animals in Turkey).Turkish Bull Hyg Exp Biol 1951; 11: 1-21.
- Gozalan A, Rolain JM, Ertek M, EAngelakis E, Coplu N, Basbulut EA, Korhasan BB, Esen B. Seroprevalence of Q fever in a district located in the west Black Sea Region of Turkey. Eur J Clin Microbiol Infect Dis 2010; 29: 465-9.
- Berberoğlu A, Gözalan S, Kılıç S, Kurtoğlu D, Esen B. A Seroprevalance of Coxiella Burnetii in Antalya, Diyarbakır and Samsun Provinces. Microbiol Bul 2004; 38: 385-91.
- Vaidya VM, Malik SV, Kaur S, Kumar S, Barbuddhe SB. Comparison of PCR, immunofluorescence assay, and pathogen isolation for diagnosis of Q fever in humans with spontaneous abortions. J Clin Microbiol 2008; 46: 2038-44.
- Baud D, Peter O, Langel C, Regan L, Greub G. Seroprevalence of Coxiella burnetii and Brucella abortus among pregnant women. Clin Microbiol Infect 2009; 15: 499-501.
- Stein A, Raoult D. Q fever during pregnancy: A Public Health Problem in Southern France Clinical Infectious Diseases 1998; 27: 592-6.
- Nielsen SY, Hjİllund NH, Andersen AM, Henriksen TB, Kantsİ B, Krogfelt KA. Presence of antibodies against Coxiella burnetii and risk of spontaneous abortion: a nested case-control study. PLoS One 2012; 7: 31909.
- Van der Hoek W, Meekelenkamp JC, Leenders AC, Wijers N, Notermans DW, Hukkelhoven CW. Antibodies against coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in the Nedherlands. BMC Infect Dis 2011; 11: 44.
- Raoult D, Fenollar F, Stein A. Q fever during pregnancy: Diagnosis, treatment, and follow-up. Arch Intern Med 2002; 162: 701-4.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Dahili Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 3 Nisan 2014 |
| Yayımlandığı Sayı | Yıl 2014 |