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Cutaneous lymphomas: A review

Yıl 2015, , 67 - 86, 01.07.2015
https://doi.org/10.7197/cmj.v37i2.5000114437

Öz

SUMMARY

Skin may be affected by non-Hodgkin lymphomas, and it is the second most frequently involved extranodal organ, after the gastrointestinal tract. Cutaneous lymphomas may originate from T, B, or NK lymphocytes. Diagnosis is difficult, and knowledge of these diseases is important to ensure their detection and adequate treatment and follow-up. Clinical picture is heterogeneous, and histology is essential to confirm the diagnosis. The classification is given by the correlation between clinical findings, histology and immunophenotyping. Therapeutic options include skin-directed therapies, immunomodulatory or low-dose immunosuppressive drugs. Rare cases of aggressive disease require systemic multidrug chemotherapy. The purpose of this review is to describe the ontogeny of T, B and NK lymphocytes, and to detail the most accepted classification of cutaneous lymphomas, proposed by the World Health Organisation and European Organisation for Research and Treatment of Cancer. Treatment of cutaneous lymphomas will be briefly discussed.

Keywords: Cutaneous lymphomas, classification, treatmen

ÖZET

Non-Hodgkin lenfomalarda cilt etkilenebilir ve gastrointestinal sistemden sonra en sık ikinci etkilenenen ekstranodal organ deridir. Kutanöz lenfomalar T, B veya NK lenfositten köken alabilir. Tanı konulması zordur ve tanınmaları ile yeterli şekilde tedavi olup izleme alınmaları için hastalığın iyi bilinmesi gerekir. Klinik tablo heterojen olup, tanının doğrulanması için histoloji önemlidir. Sınıflandırma klinik bulgular, histoloji ve immünfenotiplemedeki korelasyon ile yapılır.Tedavi seçenekleri cilde yönelik tedaviler, immünmodülatör veya düşük doz immünsupresif tedavileri içerir. Agresif seyirli nadir vakalarda sistemik çok ilaçlı kemoterapi gerekebilir. Bu derlemenin amacı T, B, ve NK lenfositlerinin ontogenisini tanımlamak ve Dünya Sağlık Örgütü ile Avrupa Kanser Araştırma ve Tedavi Örgütü’nün kutanöz lenfomalar için önerdiği en çok kabul gören sınıflandırmayı detaylandırmaktır. Kutanöz lenfomaların tedavisi de kısaca tartışılacaktır.

Anahtar sözcükler: Kutanöz lenfomalar, sınıflandırma, tedavi

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Kutanöz lenfomalar: Derleme

Yıl 2015, , 67 - 86, 01.07.2015
https://doi.org/10.7197/cmj.v37i2.5000114437

Öz

Non-Hodgkin lenfomalarda cilt etkilenebilir ve gastrointestinal sistemden sonra en sık ikinci etkilenenen ekstranodal organ deridir. Kutanöz lenfomalar T, B veya NK lenfositten köken alabilir. Tanı konulması zordur ve tanınmaları ile yeterli şekilde tedavi olup izleme alınmaları için hastalığın iyi bilinmesi gerekir. Klinik tablo heterojen olup, tanının doğrulanması için histoloji önemlidir. Sınıflandırma klinik bulgular, histoloji ve immünfenotiplemedeki korelasyon ile yapılır.Tedavi seçenekleri cilde yönelik tedaviler, immünmodülatör veya düşük doz immünsupresif tedavileri içerir. Agresif seyirli nadir vakalarda sistemik çok ilaçlı kemoterapi gerekebilir. Bu derlemenin amacı T, B, ve NK lenfositlerinin ontogenisini tanımlamak ve Dünya Sağlık Örgütü ile Avrupa Kanser Araştırma ve Tedavi Örgütü’nün kutanöz lenfomalar için önerdiği en çok kabul gören sınıflandırmayı detaylandırmaktır. Kutanöz lenfomaların tedavisi de kısaca tartışılacaktır

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  • Hoefnagel JJ, Vermeer MH, Janssen PM, Fleuren GJ, Meijer CJLM, Willemze R. Bcl-2, Bcl-6 and CD10 expression in cu- taneous B-cell lymphoma. Br J Dermatol 2003; 149: 1183-91. 110.
  • Brogan BL, Zic JA, Kin- ney MC, Hu JY, Hamilton KS, Greer JP. Large B-cell lymphoma of the leg: Clinical and pathologic characteristics in a north american series. J Am Acad Dermatol 2003; 49: 223-8. 111.
  • Suárez AL, Pulitzer M, Horwitz S, Moskowitz A, Querfeld C, Myskowski PL. Primary cuta- neous B-cell lymphomas: Part I. Clinical features, diagnosis, and classification. J Am Acad Derma- tol 2013; 69: 1-13. 112.
  • Perniciaro C, Winkelmann RK, Daoud MS, Su WPD. Malig- nant angioendotheliomatosis is anangiotropic intravascular lym- phoma: Immunohistochemical, ul- trastructural and molecular genetic studies. Am J Dermatopathol 1995; 17: 242-8. 113.
  • Nguyen GH, Yassin AH, Magro CM. Unusual variants of intravascular malignant hemato- poietic neoplasms: A report of 4 cases and review of the literature. Am J Dermatopathol 2015 in press. 114.
Toplam 126 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Derlemeler
Yazarlar

Denis Miyashiro

Jose Sanches

Yayımlanma Tarihi 1 Temmuz 2015
Yayımlandığı Sayı Yıl 2015

Kaynak Göster

AMA Miyashiro D, Sanches J. Cutaneous lymphomas: A review. CMJ. Temmuz 2015;37(2):67-86. doi:10.7197/cmj.v37i2.5000114437