Araştırma Makalesi
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Yıl 2019, , 256 - 262, 30.06.2019
https://doi.org/10.7197/223.vi.577914

Öz

Kaynakça

  • References1- Öztürk MO, Uluşahin NA. Ruh Sağlığı ve Bozuklukları (14. baskı). Ankara: Nobel tıp kitabevleri; 2016.S:242-243.
  • 2- Yavuz R. Şizofreni İ.Ü. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri 2008 S:49-58.
  • 3- Velásquez E, Nogueira FCS, Velásquez I, Schmitt A, Falkai P, Domont GB, et.al. Synaptosomal Proteome of the Orbitofrontal Cortexfrom Schizophrenia Patients Using Quantitative Label-Freeandi TRAQ-Based Shotgun Proteomics J Proteome Res. 2017:1;16(12):4481-4494.
  • 4- Soygür H, Alptekin K, Atbaşoğlu EC, Herken H. Şizofreni ve Diğer Psikotik Bozukluklar. Ankara: Türkiye Psikiyatri Derneği; 2007. S:12
  • 5- Vyas NS, Patel NH, Nijran KS, Al-Nahhas A, Puri BK. Can PET/CT imaging advance our understanding of the neurobiology of schizophrenia? Nucl Med Commun 2010;31(2):91-93.
  • 6- Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001;49:(1-2):1-52. 7- Jarskog LF, Selinger ES, Lieberman JA, Gilmore JH. Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation. American Journal of Psychiatry 2004;161(1):109-115.
  • 8- Ow YP, Green DR, Hao Z, Mak TW. Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol. 2008;9(7):532–542.
  • 9- Yuan J, Yankner BA. Apoptosis in the nervous system. Nature 2000;407(6805):802-809.
  • 10- Oltvai ZN, Milliman CL, Korsmeyer SJ, Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993;74(4):609–619.
  • 11- Sastry PS, Rao KS, Apoptosis and the nervous system. J. Neurochem. 2000;74(1):1-20.
  • 12- Cryns V, Yuan J: The cutting edge: caspases in apoptosis and disease. In When Cells Die. Edited by Lockshin RA, Zakeri Z, Tilly JL. New York: Wiley-Liss Inc; 1998:177-210.
  • 13- Fu TM, Li Y, Lu A. Li Z, Vajjhala PR, Cruz AC, et.al. Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol Cell. 2016:20;64(2):236-250.
  • 14- Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, et.al. A deatheffector domain chain DISC model reveals a crucial role for caspase-8 chainassembly in mediating apoptotic cell death. Mol Cell. 2012: 27;47(2):291-305.
  • 15- Guy W. ECDEU Assessment Manual for Psychopharmacology (028 Clinical Global Impressions [CGI]) Rockville, MD: NationalInstitutes of Health. 1976;218–222.
  • 16- Mazarakis ND, Edwards AD, Mehmet H. Apoptosis in neural development and disease. Arch Dis Child Fetal Neonatal Ed. 1997;77(3):165-70.
  • 17- Csernansky JG. Neurodegeneration in schizophrenia: evidencefrom in vivo neuro imaging studies. Scientific World Journal. 2007;7:135-143.
  • 18- Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D. Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies. Neuro psychopharmacology. 2018;43(8):1681-1690.
  • 19- Rowland LM, Pradhan S, Korenic S, Wijtenburg SA, Hong LE, Edden RA, et.al. Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study. Transl Psychiatry. 2016;6(11):e967.
  • 20- Faizi M, Salimi A, Rasoulzadeh M, Naserzadeh P, Pourahmad J. Schizophrenia induces oxidative stress and cytochrome C release in isolated rat brain mitochondria: a possible pathway for induction of apoptosis and neuro degeneration. Iran J PharmRes. 2014;13:93-100. 21- Rice MW, Smith KL, Roberts RC, Perez-Costas E, Melendez-Ferro M. Assessment of cytochrome C oxidase dysfunction in the substantia nigra/ventral tegmental area in schizophrenia. PLoSOne. 2014;9(6):100054.
  • 22- Pasdois P, Parker JE, Halestrap AP. Extent of mitochondrial hexokinase II dissociation during ischemia correlates with mitochondrial cytochrome c release, reactive oxygen species production, and infarct size on reperfusion. J AmHeartAssoc. 2012;2(1):e005645.
  • 23- Jarskog LF, Gilmore JH, Selinger ES, Lieberman JA. Cortical bcl-2 protein expression and apoptotic regulation in schizophrenia. Biol. Psychiatry 2000;48(7): 641–650.
  • 24- Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I. Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage. Front Immunol. 2016;7:279.
  • 25- Djordjević VV, Ristić T, Lazarević D, Cosić V, Vlahović P, Djordjević VB. Schizophrenia is associated with increased levels of serum Fas and FasL. Clin. Chem. Lab. Med. 2012;50(6):1049-1054.
  • 26- Goldsmith DR, Haroon E, Miller AH, Strauss GP, Buckley PF, Miller BJ. TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia. Schizophr Res. 2018: 2018;199:281-284.
  • 27- Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 2000;12(6):621-632.
  • 28- Jeong JH, Kim DK, Lee NS. Jeong YG1, Kim HW2, Kim JS, et.al. Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction. ASN Neuro. 2018;10:1759091418810583

The apoptotic paradox in schizophrenia

Yıl 2019, , 256 - 262, 30.06.2019
https://doi.org/10.7197/223.vi.577914

Öz

Objective: Understanding the role of
apoptosis in abnormal neurodevelopment and neurodegenerative processes is
crucial. In this study, it is aimed to determine how apoptosis biomarkers are
affected in patients with schizophrenia and severity of the disease and also whether
apoptosis biomarkers can be used as blood-based biomarkers in diagnosis of the
disease.

Method: This is a cross-sectional prospective study performed at a tertiary
university hospital and city hospital in Turkey.
Volunteers
(n=60) diagnosed with schizophrenia were divided into three groups (Mild,
Moderate and Severe) according to the Clinical Global Impressions Scale
developed by Guy. The control group was constituted from volunteers who were
similar to the patient group (n=40) in terms of age and gender. Serum levels of
Caspase-8(C-8), Granzyme B (GrB) and Cytcochrome C (CYCS) were measured by
ELISA method from blood samples collected from patient and control groups.

Results: It was observed that Caspase 8 and GrB levels
were lower in all three groups compared with the control group, and the highest
decrease was in the 3rd group (P<0,.5). CYCS level on the other hand
increased, and the highest increase was observed in 3rd Group (P<0.05).







Conclusions: It is hypothesised that increase in serum CYCS level of patients with
schizophrenia may be a blood based biomarker in which apoptosis occurs.      

Kaynakça

  • References1- Öztürk MO, Uluşahin NA. Ruh Sağlığı ve Bozuklukları (14. baskı). Ankara: Nobel tıp kitabevleri; 2016.S:242-243.
  • 2- Yavuz R. Şizofreni İ.Ü. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri 2008 S:49-58.
  • 3- Velásquez E, Nogueira FCS, Velásquez I, Schmitt A, Falkai P, Domont GB, et.al. Synaptosomal Proteome of the Orbitofrontal Cortexfrom Schizophrenia Patients Using Quantitative Label-Freeandi TRAQ-Based Shotgun Proteomics J Proteome Res. 2017:1;16(12):4481-4494.
  • 4- Soygür H, Alptekin K, Atbaşoğlu EC, Herken H. Şizofreni ve Diğer Psikotik Bozukluklar. Ankara: Türkiye Psikiyatri Derneği; 2007. S:12
  • 5- Vyas NS, Patel NH, Nijran KS, Al-Nahhas A, Puri BK. Can PET/CT imaging advance our understanding of the neurobiology of schizophrenia? Nucl Med Commun 2010;31(2):91-93.
  • 6- Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001;49:(1-2):1-52. 7- Jarskog LF, Selinger ES, Lieberman JA, Gilmore JH. Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation. American Journal of Psychiatry 2004;161(1):109-115.
  • 8- Ow YP, Green DR, Hao Z, Mak TW. Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol. 2008;9(7):532–542.
  • 9- Yuan J, Yankner BA. Apoptosis in the nervous system. Nature 2000;407(6805):802-809.
  • 10- Oltvai ZN, Milliman CL, Korsmeyer SJ, Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993;74(4):609–619.
  • 11- Sastry PS, Rao KS, Apoptosis and the nervous system. J. Neurochem. 2000;74(1):1-20.
  • 12- Cryns V, Yuan J: The cutting edge: caspases in apoptosis and disease. In When Cells Die. Edited by Lockshin RA, Zakeri Z, Tilly JL. New York: Wiley-Liss Inc; 1998:177-210.
  • 13- Fu TM, Li Y, Lu A. Li Z, Vajjhala PR, Cruz AC, et.al. Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol Cell. 2016:20;64(2):236-250.
  • 14- Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, et.al. A deatheffector domain chain DISC model reveals a crucial role for caspase-8 chainassembly in mediating apoptotic cell death. Mol Cell. 2012: 27;47(2):291-305.
  • 15- Guy W. ECDEU Assessment Manual for Psychopharmacology (028 Clinical Global Impressions [CGI]) Rockville, MD: NationalInstitutes of Health. 1976;218–222.
  • 16- Mazarakis ND, Edwards AD, Mehmet H. Apoptosis in neural development and disease. Arch Dis Child Fetal Neonatal Ed. 1997;77(3):165-70.
  • 17- Csernansky JG. Neurodegeneration in schizophrenia: evidencefrom in vivo neuro imaging studies. Scientific World Journal. 2007;7:135-143.
  • 18- Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D. Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies. Neuro psychopharmacology. 2018;43(8):1681-1690.
  • 19- Rowland LM, Pradhan S, Korenic S, Wijtenburg SA, Hong LE, Edden RA, et.al. Elevated brain lactate in schizophrenia: a 7 T magnetic resonance spectroscopy study. Transl Psychiatry. 2016;6(11):e967.
  • 20- Faizi M, Salimi A, Rasoulzadeh M, Naserzadeh P, Pourahmad J. Schizophrenia induces oxidative stress and cytochrome C release in isolated rat brain mitochondria: a possible pathway for induction of apoptosis and neuro degeneration. Iran J PharmRes. 2014;13:93-100. 21- Rice MW, Smith KL, Roberts RC, Perez-Costas E, Melendez-Ferro M. Assessment of cytochrome C oxidase dysfunction in the substantia nigra/ventral tegmental area in schizophrenia. PLoSOne. 2014;9(6):100054.
  • 22- Pasdois P, Parker JE, Halestrap AP. Extent of mitochondrial hexokinase II dissociation during ischemia correlates with mitochondrial cytochrome c release, reactive oxygen species production, and infarct size on reperfusion. J AmHeartAssoc. 2012;2(1):e005645.
  • 23- Jarskog LF, Gilmore JH, Selinger ES, Lieberman JA. Cortical bcl-2 protein expression and apoptotic regulation in schizophrenia. Biol. Psychiatry 2000;48(7): 641–650.
  • 24- Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I. Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage. Front Immunol. 2016;7:279.
  • 25- Djordjević VV, Ristić T, Lazarević D, Cosić V, Vlahović P, Djordjević VB. Schizophrenia is associated with increased levels of serum Fas and FasL. Clin. Chem. Lab. Med. 2012;50(6):1049-1054.
  • 26- Goldsmith DR, Haroon E, Miller AH, Strauss GP, Buckley PF, Miller BJ. TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia. Schizophr Res. 2018: 2018;199:281-284.
  • 27- Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 2000;12(6):621-632.
  • 28- Jeong JH, Kim DK, Lee NS. Jeong YG1, Kim HW2, Kim JS, et.al. Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction. ASN Neuro. 2018;10:1759091418810583
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Basic Science Research Makaleler
Yazarlar

Hüseyin Aydın 0000-0002-3194-830X

Yusuf Kenan Tekin 0000-0001-8047-4836

Serpil Erşan 0000-0002-8968-4044

Hayrettin Yavuz 0000-0001-5190-7022

Ethem Erdal Erşan 0000-0002-7104-2908

Yayımlanma Tarihi 30 Haziran 2019
Kabul Tarihi 24 Haziran 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

AMA Aydın H, Tekin YK, Erşan S, Yavuz H, Erşan EE. The apoptotic paradox in schizophrenia. CMJ. Haziran 2019;41(2):256-262. doi:10.7197/223.vi.577914