Araştırma Makalesi
Yıl 2021,
, 117 - 123, 01.07.2021
Öz
Kaynakça
- Referans1. Bilezikian JP, Bandeira L, Khan A, et al. Hyperparathyroidism. Lancet 2018;391:168e78.) (Bilezikian JP, Cusano NE, Khan AA, et al. Primary hyperparathyroidism. Nat Rev Dis Primers 2016;2:16033.
- Referans2. Neer NM, Arnaud CD, Zanchetta JR, Price R,Gaich GA, Reginster JY, et al. Effect of Parathyroid hormone (1-34) on fractures and bone mineral dansity im postmenopausal women with osteoporosis. N Engl Med 2001;344(19):1434-41. doi: 10.1056/NEJM200105103441904.
- Referans3. Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS. Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collogen synthesis in osteobalstic MC3T3-El cells. Nutr Res Pract 2010:4; 356-361.
- Referans4. Kubıak K, Klımczak A, Dzıkı L, Modranka R, Malınowska K: Influence of copper (II) complex on the activity of selected oxidative enzymes. (In Polish) Pol Merkur Lekarski 28: 22-25, 2010.
- Referans5. Lı Bb, Yu Sf: In vitro study of the effects of copper ion on osteoclastic resorption in various dental mineralized tissues. Zhoghua Kou Qiang Yi Xue Za Zhi 42: 110-113, 2007.
- Referans6. Zofkova I, Davıs M, Blahos J. Trace Elements Have Beneficial, as Well as Detrimental Effects on Bone Homeostasis. Physiol. Res. 66: 391-402, 2017.
- Referans7. Osteoporoz Ve Metabolik Kemik Hastalıkları Tanı Ve Tedavi Kılavuzu. Türkiye Endokrinoloji ve Metabolizma Derneği. ISBN: 978-605-66410-1-5. 13. Baskı: Mayıs 2018.
- Referans8. Azza A El Tayeb, Nashwa A Abd El-Mottaleb, Ebtihal A Abdel Aziz. Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children. Biol Trace Elem Res. 2009 May;128(2):128-34.
- Referans9. O'Connor JP, Kanjilal D, Teitelbaum M, Lin SS, Cottrell JA. Zinc as a Therapeutic Agent in Bone Regeneration. Materials (Basel). 2020;13(10):2211. doi: 10.3390/ma13102211.
- Referans10. Suzuki T, Kajita Y, Katsumata S, Matsuzaki H, Suzuki K (2015) Zinc deficiency increases serum concentrations of parathyroid hor- mone through a decrease in serum calcium and induces bone fra- gility in rats. J Nutr Sci Vitaminol (Tokyo) 61(5):382–390. https:// doi.org/10.3177/jnsv.61.382.
- Referans11. El Tayeb AA, Abd El-Mottaleb NA, Abdel Aziz EA. Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children. Biol Trace Elem Res (2009) 128:128–134. DOI 10.1007/s12011-008-8265-x.
- Referans12. Chen SM, Deng C, Iaio JF, HO LT (2005) Effects of parathyroid hormone on plasma zinc concentration in rat with chronic renal failure. Chin J Physiol 48(2):121–128.
- Referans13. Simin Dashti-Khavidaki, Hossein Khalili, Seyedeh-Maryam Vahedi, Mahboob Lessan- Pezeshki. Serum Zinc Concentrations in Patients on Maintenance Hemodialysis and its Relationship with Anemia, Parathyroid Hormone Concentrations and Pruritus Severity. Saudi J Kidney Dis Transpl 2010;21(4):641-645.
- Referans14. Malette LE, Henkin RI. Altered Copper and Zinc Metabolism in Primary Hyperparathyroidism. Am J Med Sci. 1976; 272(2):167-74.
- Referans15. Deska M, Romuk E, Segiet OA, Buła G, Truchanowski W, Stolecka D, Birkner E, Gawrychowski Oxidative stress and angiogenesis in primary hyperparathyroidism. J. Eur Surg. 2017;49(3):118-126. doi: 10.1007/s10353-016-0457-6. Epub 2016 Dec 14.)
Yıl 2021,
, 117 - 123, 01.07.2021
Öz
Objective: Primary hyperparathyroidism (PHPTH) is an endocrine disorder with hypercalcemia due to increased parathormone (PTH) release. This study aims to investigate the relationship between PHPTH and serum zinc and copper levels.
Method: 35 patients diagnosed with PHPT and 30 healthy control cases were included in the study. Serum zinc and copper levels were measured in all patients.
Results: There was no difference between the groups in terms of age and gender. It was detected that serum Zn levels were significantly lower and serum Cu levels were higher in the PHPTH group compared to the control group (PHPTH Zn: 85.8±24.9 μ/dL, Cu: 81.2±13.8 μ/dL and Control Zn: 103.3±21.3 μ/dL, Cu: 72.6±13.3 μ/dL p = 0.004, p= 0.013, respectively). There was a weak positive correlation between serum Cu levels and PTH levels.
Conclusions: Serum zinc and copper levels should be considered in the clarification of the pathogenesis of PHPTH and in treatment planning.
Anahtar Kelimeler
Kaynakça
- Referans1. Bilezikian JP, Bandeira L, Khan A, et al. Hyperparathyroidism. Lancet 2018;391:168e78.) (Bilezikian JP, Cusano NE, Khan AA, et al. Primary hyperparathyroidism. Nat Rev Dis Primers 2016;2:16033.
- Referans2. Neer NM, Arnaud CD, Zanchetta JR, Price R,Gaich GA, Reginster JY, et al. Effect of Parathyroid hormone (1-34) on fractures and bone mineral dansity im postmenopausal women with osteoporosis. N Engl Med 2001;344(19):1434-41. doi: 10.1056/NEJM200105103441904.
- Referans3. Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS. Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collogen synthesis in osteobalstic MC3T3-El cells. Nutr Res Pract 2010:4; 356-361.
- Referans4. Kubıak K, Klımczak A, Dzıkı L, Modranka R, Malınowska K: Influence of copper (II) complex on the activity of selected oxidative enzymes. (In Polish) Pol Merkur Lekarski 28: 22-25, 2010.
- Referans5. Lı Bb, Yu Sf: In vitro study of the effects of copper ion on osteoclastic resorption in various dental mineralized tissues. Zhoghua Kou Qiang Yi Xue Za Zhi 42: 110-113, 2007.
- Referans6. Zofkova I, Davıs M, Blahos J. Trace Elements Have Beneficial, as Well as Detrimental Effects on Bone Homeostasis. Physiol. Res. 66: 391-402, 2017.
- Referans7. Osteoporoz Ve Metabolik Kemik Hastalıkları Tanı Ve Tedavi Kılavuzu. Türkiye Endokrinoloji ve Metabolizma Derneği. ISBN: 978-605-66410-1-5. 13. Baskı: Mayıs 2018.
- Referans8. Azza A El Tayeb, Nashwa A Abd El-Mottaleb, Ebtihal A Abdel Aziz. Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children. Biol Trace Elem Res. 2009 May;128(2):128-34.
- Referans9. O'Connor JP, Kanjilal D, Teitelbaum M, Lin SS, Cottrell JA. Zinc as a Therapeutic Agent in Bone Regeneration. Materials (Basel). 2020;13(10):2211. doi: 10.3390/ma13102211.
- Referans10. Suzuki T, Kajita Y, Katsumata S, Matsuzaki H, Suzuki K (2015) Zinc deficiency increases serum concentrations of parathyroid hor- mone through a decrease in serum calcium and induces bone fra- gility in rats. J Nutr Sci Vitaminol (Tokyo) 61(5):382–390. https:// doi.org/10.3177/jnsv.61.382.
- Referans11. El Tayeb AA, Abd El-Mottaleb NA, Abdel Aziz EA. Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children. Biol Trace Elem Res (2009) 128:128–134. DOI 10.1007/s12011-008-8265-x.
- Referans12. Chen SM, Deng C, Iaio JF, HO LT (2005) Effects of parathyroid hormone on plasma zinc concentration in rat with chronic renal failure. Chin J Physiol 48(2):121–128.
- Referans13. Simin Dashti-Khavidaki, Hossein Khalili, Seyedeh-Maryam Vahedi, Mahboob Lessan- Pezeshki. Serum Zinc Concentrations in Patients on Maintenance Hemodialysis and its Relationship with Anemia, Parathyroid Hormone Concentrations and Pruritus Severity. Saudi J Kidney Dis Transpl 2010;21(4):641-645.
- Referans14. Malette LE, Henkin RI. Altered Copper and Zinc Metabolism in Primary Hyperparathyroidism. Am J Med Sci. 1976; 272(2):167-74.
- Referans15. Deska M, Romuk E, Segiet OA, Buła G, Truchanowski W, Stolecka D, Birkner E, Gawrychowski Oxidative stress and angiogenesis in primary hyperparathyroidism. J. Eur Surg. 2017;49(3):118-126. doi: 10.1007/s10353-016-0457-6. Epub 2016 Dec 14.)
Toplam 15 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Basic Science Research Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Temmuz 2021 |
| Kabul Tarihi | 29 Haziran 2021 |
| Yayımlandığı Sayı | Yıl 2021 |