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Yıl 2021, , 100 - 116, 01.07.2021

Şeyma Taştemur , Hilmi Ataseven

https://doi.org/10.7197/cmj.939856

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Quercetin in the treatment and prevention of COVID-19

Yıl 2021, , 100 - 116, 01.07.2021

Şeyma Taştemur , Hilmi Ataseven

https://doi.org/10.7197/cmj.939856

Öz

Coronavirus Disease-19 ( COVID-19) is a disease that started at the end of 2019 and continues to affect all the world as a pandemic. There is no definitive cure for COVID-19 yet. The disease is characterized by excessive immune activity, inflammation and coagulopathy. Many agents have been tried for treatment and prevention. Flavonoids are valuable natural food components with antioxidant, anti-inflammatory and anticoagulant properties. Quercetin, the best known flavonoid, is one of the most studied and beneficial one. Quercetin, which has been shown to be effective in many viral diseases, is mainly used in diseases such as cardiovascular disease and diabetes, which are associated with chronic inflammation. it is an important candidate for the treatment and prophylaxis of COVID-19, thanks to its powerful anti-inflammatory, antioxidant and immune-modulating effects.

Anahtar Kelimeler

Quercetin COVID-19 treatment

Kaynakça

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  • 131. Ng, L. F., Hibberd, M. L., Ooi, E. E., Tang, K. F., Neo, S. Y., Tan, J., Murthy, K. R., Vega, V. B., Chia, J. M., Liu, E. T., & Ren, E. C. (2004). A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection. BMC infectious diseases, 4, 34. https://doi.org/10.1186/1471-2334-4-34
  • 132. Poon, T. C., Pang, R. T., Chan, K. C., Lee, N. L., Chiu, R. W., Tong, Y. K., Chim, S. S., Ngai, S. M., Sung, J. J., & Lo, Y. M. (2012). Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome. Electrophoresis, 33(12), 1894–1900. https://doi.org/10.1002/elps.201200002
  • 133. Subramaniam, S., & Scharrer, I. (2018). Procoagulant activity during viral infections. Frontiers in bioscience (Landmark edition), 23, 1060–1081. https://doi.org/10.2741/4633
  • 134. Lupu, F., Keshari, R. S., Lambris, J. D., & Coggeshall, K. M. (2014). Crosstalk between the coagulation and complement systems in sepsis. Thrombosis research, 133 Suppl 1(0 1), S28–S31. https://doi.org/10.1016/j.thromres.2014.03.014
  • 135. Gragnano, F., Sperlongano, S., Golia, E., Natale, F., Bianchi, R., Crisci, M., Fimiani, F., Pariggiano, I., Diana, V., Carbone, A., Cesaro, A., Concilio, C., Limongelli, G., Russo, M., & Calabrò, P. (2017). The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy. Mediators of inflammation, 2017, 5620314. https://doi.org/10.1155/2017/5620314
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  • 137. Guglielmone, H. A., Nuñez-Montoya, S. C., Agnese, A. M., Pellizas, C. G., Cabrera, J. L., & Donadio, A. C. (2012). Quercetin 3,7,3′,4′-tetrasulphated isolated from Flaveria bidentis inhibits tissue factor expression in human monocyte. Phytomedicine, 19(12), 1068–1071. doi:10.1016/j.phymed.2012.06.013
  • 138. Guglielmone, H. A., Agnese, A. M., Nuñez-Montoya, S. G., Cabrera, J. L., & Cuadra, G. R. (2020). Antithrombotic “in vivo” effects of quercetin 3,7,3′,4′-tetrasulfate isolated from Flaveria bidentis in an experimental thrombosis model in mice. Thrombosis Research. doi:10.1016/j.thromres.2020.07.040
  • 139. Stainer, A. R., Sasikumar, P., Bye, A. P., Unsworth, A. J., Holbrook, L. M., Tindall, M., Lovegrove, J. A., & Gibbins, J. M. (2019). The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects. TH open : companion journal to thrombosis and haemostasis, 3(3), e244–e258. https://doi.org/10.1055/s-0039-1694028
  • 140. Oh, W. J., Endale, M., Park, S. C., Cho, J. Y., & Rhee, M. H. (2012). Dual Roles of Quercetin in Platelets: Phosphoinositide-3-Kinase and MAP Kinases Inhibition, and cAMP-Dependent Vasodilator-Stimulated Phosphoprotein Stimulation. Evidence-based complementary and alternative medicine : eCAM, 2012, 485262. https://doi.org/10.1155/2012/485262
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  • 147. Wu Y, Guo C, Tang L, Hong Z, Zhou J et al. (2020). Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterology and Hepatology 5 (5): 434-435. https://doi.org/10.1016/ S2468-1253(20)30083-2
  • 148. Aktas, B., & Aslim, B. (2020). Gut-lung axis and dysbiosis in COVID-19. Turkish journal of biology = Turk biyoloji dergisi, 44(3), 265–272. https://doi.org/10.3906/biy-2005-102
  • 149. Pei, R., Liu, X., & Bolling, B. (2020). Flavonoids and gut health. Current Opinion in Biotechnology, 61, 153–159. https://doi.org/10.1016/j.copbio.2019.12.018
  • 150. Shi T, Bian X, Yao Z, et al. Quercetin improves gut dysbiosis in antibiotic-treated mice. Food & Function. 2020 Sep;11(9):8003-8013. https://doi.org/10.1039/d0fo01439g.
  • 151. Etxeberria, U., Arias, N., Boqué, N., Macarulla, M. T., Portillo, M. P., Martínez, J. A., & Milagro, F. I. (2015). Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. The Journal of Nutritional Biochemistry, 26(6), 651–660. https://doi.org/10.1016/j.jnutbio.2015.01.002
Toplam 149 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Derlemeler
Yazarlar

Şeyma Taştemur 0000-0002-9013-6395

Hilmi Ataseven 0000-0001-5458-509X

Yayımlanma Tarihi 1 Temmuz 2021
Kabul Tarihi 1 Temmuz 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

AMA Taştemur Ş, Ataseven H. Quercetin in the treatment and prevention of COVID-19. CMJ. Temmuz 2021;43(2):100-116. doi:10.7197/cmj.939856