The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma
Öz
The anticancer activities 3-(substituted phenyl)-1-[4-(morpholine-4-yl)phenyl]prop-2-en-1-one derivatives were investigated against PC3 (Human Prostate Carcinoma Cell) and HT29 (Human colon colorectal adenocarcinoma) cell lines. The anticancer activity tests were performed by the BrdU ELISA method. 5-Fluorouracil (5-FU) was used as standard compound. Compound 1-7 (except Compound 3) were determined to have higher anticancer activity than 5-FU aganist PC3 cancer cells. IC50 values of the Compounds 1-7 against PC3 cancer cells were 2.53±0.02 µM; 4.40±0.03 µM; 4.36±0.03 µM; 1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM, respectively.
Anahtar Kelimeler
HT29 PC3 Chalcone 5-Fluorouracil Fluor atom anticancer activity
Destekleyen Kurum
Gaziantep University Scientific Research Projects Governing Unit (BAPYB) (Project no: FEF.14.01), Turkey
Proje Numarası
Project no: FEF.14.01
Teşekkür
This study was supported by the Gaziantep University Scientific Research Projects Governing Unit (BAPYB) (Project no: FEF.14.01), Turkey
Kaynakça
- Reference1: Prof. Dr. İbrahim Demirtaş (ibdemirtas@gmail.com) Reference2: Prof. Dr. Nurettin Yaylı (nurettin yayli@ktu.edu.tr )
Öz
Proje Numarası
Project no: FEF.14.01
Kaynakça
- Reference1: Prof. Dr. İbrahim Demirtaş (ibdemirtas@gmail.com) Reference2: Prof. Dr. Nurettin Yaylı (nurettin yayli@ktu.edu.tr )
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Yapısal Biyoloji |
| Bölüm | Makale |
| Yazarlar | |
| Proje Numarası | Project no: FEF.14.01 |
| Yayımlanma Tarihi | 30 Haziran 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 5 Sayı: 1 |
Kaynak Göster
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.