Öz
Özet
Amaç. Hiperkolesterolemi ateroskleroz nedenleri arasında en önemlisidir. Serum lipid bozuklukları çocukluk çağında başlar ve aterosklerotik lezyon yaşamın erken döneminde oluşur. Bu çalışmada, kordon kanı lipid profili ile gestasyonel parametreler, maternal parametreler ve maternal lipid profili karşılaştırıldı. Yöntem. Kordon kanında ve anne serumunda total kolestrol, trigliserit, yüksek dansiteli lipoprotein (YDL), düşük dansiteli lipoprotein, çok düşük dansiteli lipoprotein düzeyleri ölçüldü. Kordon kanı lipid düzeyleri ile bebeğe ait ve anneye ait parametreler arasında ilişki olup olmadığı araştırıldı. Bulgular. Kord kanı lipid düzeyleri yetişkin değerlerinden düşüktü. Kord kanı YDL düzeyi ile maternal YDL düzeyi arasında pozitif yönlü korelasyon vardı (p=0,03). Trigliserit-kolesterol ve YDL dışındaki diğer lipoprotein düzeylerinde, kord ve anne serumu arasında anlamlı bir farklılık saptanmadı (p>0,05). Sonuç. Bu çalışmada kord kanı YDL düzeyinin, ateroskleroz gelişimi belirlemede prediktif değeri olabileceği kanısına ulaşıldı.
Anahtar sözcükler: Ateroskleroz, lipid düzeyleri, yüksek dansiteli lipoprotein, kord kanı, yenidoğan
Abstract
Aim. Hypercholesterolemia is the most important causes of atherosclerosis. Serum lipid abnormalities begin in childhood and that atherosclerotic lesions emerge early in life. In this study, the lipid profiles of the cord blood in newborns were compared in terms of gestational parameters, maternal parameters, maternal lipid profiles .Method. Plasma total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein and very low density lipoprotein were measured in the cord blood of newborns and in serum of the mothers. The relations between cord plasma lipids values and clinical findings of newborns and their mothers were investigated. Results. Cord blood lipid levels were lower than those in adults. Cord blood HDL levels were correlated positively with maternal HDL levels (r= 0.419, p=0.03). However, there were no significant relations between the triglycerides-cholesterol and other lipoproteins levels in cord and maternal blood (p>0.05). Conclusion. We suggest that cord blood HDL levels have a predictive value in the development of the atherosclerosis in later stages of life.
Key words: Atherosclerosis, lipid levels, high density lipoprotein, cord blood, newborn
Anahtar Kelimeler
Kaynakça
- Schaefer EJ. Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 2002; 75: 191- 212.
- Palinski W, Napoli C. The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB J 2002; 16: 1348-60.
- Kumar A. Gupta A. Malhotra VK, AgarwalI PS, Thirupuram S, Gaind B: Cord Blood Lipid Levels in Low Birth Weight Newborns. Indian Pediatr 1989; 26: 571-4.
- Freedman DS, Srinivasan SR, Cresanta JL, Webber LS, Berenson GS. Cardiovascular risk factors from birth to 7 years of age: the Bogalusa Heart Study. Serum lipids and lipoproteins. Pediatrics 1987; 80: 789-96.
- Mayes PA: Biosynthesis of fatty acids. Harper's Biochemistry, 24 th edition (Ed: Murray RK, Granner DK, Mates PA, Rodwell VW) Stanford, Appleton & Lange 1996: 216-23.
- Mayes PA: Lipids of physiologic significance. Harper's Biochemistry, 24 th edition (Ed: Murray RK, Granner DK, Mayes PA, Rodwell VW) Stanford, Appleton & Lange 1996:146-57.
- Bierman EL, Glomset JA: Disorders of lipid metabelism. Williams Textbook of Endocrinology, 8 th edition (Ed: Wilson JD, Foster DW) Philadelphia, W. B. Saunders Co 1992:1367-95.
- Tershakovec AM, Rader DJ.: Disorders of Lipoprotein Metobolism and Transport. In: Nelson Berhman RE, Kliegman RM, Jenson HB. Textbook of Pediatrics. 16th ed. Philadelphia: W.B. Saunders Co 2001: 387-98.
- McGill HC Jr. Smoking and the pathogenesis of atherosclerosis. Adv Exp Med Biol 1990; 273:9-16.
- Nakai T, Tamai T, Yamada S, Kobayashi T, Hayashi T, Kutsumi Y, Oida K, Takeda R. Plasma lipids and lipoproteins of Japanese adults and umbilical cord blood. Artery 1981; 9: 132-50.
- Yoshimitsu N, Douchi T, Yamasaki H, Nagata Y, Andoh T, Hatano H. Differences in umbilical cord serum lipid levels with mode of delivery. Br J Obstet Gynaecol 1999; 106:144-7.
- American Healt Fundation 1979. Position statement on diet and coronary heart disease. American health Foundation. Prev Med 1972; 1: 255-86.
- Ojwang PJ, Ogada T, Maina FW, Sekadde-Kigondu CB, Mati JK. Reference values for serum lipids and lipoprotein cholesterol in adults and cord blood of Kenyan Africans. East Afr Med J 1984; 61: 367-71.
- Mahley RW, Aslan P, Pekcan P, Pepin GM, Ağaçdiken A, Karaağaoğlu N, Rakıcıoğlu N, Nursal B, Dayanıklı P, Paloğlu KE, Bersot TP. Plazma Lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plazma cholesterol and YDL. J Lipis Res 2001; 42: 1996-2004.
- Göçmen İ, Karademir F, Ezdar İ, Gültepe M, Öztosun M, Mete Z, Tuncer M. Term bebeklerin kordon kanında lipid, lipoprotein ve apolipoproteinler. GATA Bülteni 1995; 37: 88-94.
- Knopp RH, Bergelin RO, Wahl PW. Population-based lipoprotein lipid reference values for pregnant women compared to nonpregnant women classified by sex hormone usage. Am J Obstet Gynecol 1982;143:626-36.
- Gordon DJ, Rifkind BM. High-density lipoprotein--the clinical implications of recent studies. N Engl J Med 1989; 321: 1311-6.
- Castelli WP. Exercise and high-density lipoproteins. JAMA 1979;242:2217.
- Lauer RM, Lee J, Clarke WR. Factors affecting the relationship between childhood and adult cholesterol levels: The Muscatine Study. Pediatrics 1988; 82: 309-18.
- Fonnebo V, Dahl LB, Moe PJ, Ingebretsen OC. Does VLDL-LDL-cholesterol in cord serum predict future level of lipoproteins? Acta Paediatr Scand 1991; 80: 780-5.
- Tsang RC, Glueck CJ. Perinatal cholesterol metabolism.Clin Perinatol 1975; 2: 275-94.
- Darmady JM, Fosbrooke AS, Lloyd JK. Prospective study of serum cholesterol levels during first year of life. Br Med J 1972; 2: 685-8.
- Fosbrooke AS, Wharton BA. Plazma lipids in umblical cord blood from infants of normal and low birth weight. Biol Neonate 1973; 23: 330-8.
- Diaz M, Leal C, Ramon y Cajal J, Jimenez MD, Martinez H, Pocovi M, Grande F. Cord blood lipoprotein-cholesterol: relationship birth weight and gestational age of newborns. Metabolism 1989; 38: 435-8.
- Leeson CPM, Kattenhorn M, Morley R, Lucas A, Deanfeald JE. Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation 2001; 103: 1264-8
Öz
Amaç. Hiperkolesterolemi ateroskleroz nedenleri arasında en önemlisidir. Serum lipid bozuklukları çocukluk çağında başlar ve aterosklerotik lezyon yaşamın erken döneminde oluşur. Bu çalışmada, kordon kanı lipid profili ile gestasyonel parametreler, maternal parametreler ve maternal lipid profili karşılaştırıldı. Yöntem. Kordon kanında ve anne serumunda total kolestrol, trigliserit, yüksek dansiteli lipoprotein (YDL), düşük dansiteli lipoprotein, çok düşük dansiteli lipoprotein düzeyleri ölçüldü. Kordon kanı lipid düzeyleri ile bebeğe ait ve anneye ait parametreler arasında ilişki olup olmadığı araştırıldı. Bulgular. Kord kanı lipid düzeyleri yetişkin değerlerinden düşüktü. Kord kanı YDL düzeyi ile maternal YDL düzeyi arasında pozitif yönlü korelasyon vardı (p=0,03). Trigliserit-kolesterol ve YDL dışındaki diğer lipoprotein düzeylerinde, kord ve anne serumu arasında anlamlı bir farklılık saptanmadı (p>0,05). Sonuç. Bu çalışmada kord kanı YDL düzeyinin, ateroskleroz gelişimi belirlemede prediktif değeri olabileceği kanısına ulaşıldı
Anahtar Kelimeler
Ateroskleroz lipid düzeyleri yüksek dansiteli lipoprotein kord kanı yenidoğan
Kaynakça
- Schaefer EJ. Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 2002; 75: 191- 212.
- Palinski W, Napoli C. The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB J 2002; 16: 1348-60.
- Kumar A. Gupta A. Malhotra VK, AgarwalI PS, Thirupuram S, Gaind B: Cord Blood Lipid Levels in Low Birth Weight Newborns. Indian Pediatr 1989; 26: 571-4.
- Freedman DS, Srinivasan SR, Cresanta JL, Webber LS, Berenson GS. Cardiovascular risk factors from birth to 7 years of age: the Bogalusa Heart Study. Serum lipids and lipoproteins. Pediatrics 1987; 80: 789-96.
- Mayes PA: Biosynthesis of fatty acids. Harper's Biochemistry, 24 th edition (Ed: Murray RK, Granner DK, Mates PA, Rodwell VW) Stanford, Appleton & Lange 1996: 216-23.
- Mayes PA: Lipids of physiologic significance. Harper's Biochemistry, 24 th edition (Ed: Murray RK, Granner DK, Mayes PA, Rodwell VW) Stanford, Appleton & Lange 1996:146-57.
- Bierman EL, Glomset JA: Disorders of lipid metabelism. Williams Textbook of Endocrinology, 8 th edition (Ed: Wilson JD, Foster DW) Philadelphia, W. B. Saunders Co 1992:1367-95.
- Tershakovec AM, Rader DJ.: Disorders of Lipoprotein Metobolism and Transport. In: Nelson Berhman RE, Kliegman RM, Jenson HB. Textbook of Pediatrics. 16th ed. Philadelphia: W.B. Saunders Co 2001: 387-98.
- McGill HC Jr. Smoking and the pathogenesis of atherosclerosis. Adv Exp Med Biol 1990; 273:9-16.
- Nakai T, Tamai T, Yamada S, Kobayashi T, Hayashi T, Kutsumi Y, Oida K, Takeda R. Plasma lipids and lipoproteins of Japanese adults and umbilical cord blood. Artery 1981; 9: 132-50.
- Yoshimitsu N, Douchi T, Yamasaki H, Nagata Y, Andoh T, Hatano H. Differences in umbilical cord serum lipid levels with mode of delivery. Br J Obstet Gynaecol 1999; 106:144-7.
- American Healt Fundation 1979. Position statement on diet and coronary heart disease. American health Foundation. Prev Med 1972; 1: 255-86.
- Ojwang PJ, Ogada T, Maina FW, Sekadde-Kigondu CB, Mati JK. Reference values for serum lipids and lipoprotein cholesterol in adults and cord blood of Kenyan Africans. East Afr Med J 1984; 61: 367-71.
- Mahley RW, Aslan P, Pekcan P, Pepin GM, Ağaçdiken A, Karaağaoğlu N, Rakıcıoğlu N, Nursal B, Dayanıklı P, Paloğlu KE, Bersot TP. Plazma Lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plazma cholesterol and YDL. J Lipis Res 2001; 42: 1996-2004.
- Göçmen İ, Karademir F, Ezdar İ, Gültepe M, Öztosun M, Mete Z, Tuncer M. Term bebeklerin kordon kanında lipid, lipoprotein ve apolipoproteinler. GATA Bülteni 1995; 37: 88-94.
- Knopp RH, Bergelin RO, Wahl PW. Population-based lipoprotein lipid reference values for pregnant women compared to nonpregnant women classified by sex hormone usage. Am J Obstet Gynecol 1982;143:626-36.
- Gordon DJ, Rifkind BM. High-density lipoprotein--the clinical implications of recent studies. N Engl J Med 1989; 321: 1311-6.
- Castelli WP. Exercise and high-density lipoproteins. JAMA 1979;242:2217.
- Lauer RM, Lee J, Clarke WR. Factors affecting the relationship between childhood and adult cholesterol levels: The Muscatine Study. Pediatrics 1988; 82: 309-18.
- Fonnebo V, Dahl LB, Moe PJ, Ingebretsen OC. Does VLDL-LDL-cholesterol in cord serum predict future level of lipoproteins? Acta Paediatr Scand 1991; 80: 780-5.
- Tsang RC, Glueck CJ. Perinatal cholesterol metabolism.Clin Perinatol 1975; 2: 275-94.
- Darmady JM, Fosbrooke AS, Lloyd JK. Prospective study of serum cholesterol levels during first year of life. Br Med J 1972; 2: 685-8.
- Fosbrooke AS, Wharton BA. Plazma lipids in umblical cord blood from infants of normal and low birth weight. Biol Neonate 1973; 23: 330-8.
- Diaz M, Leal C, Ramon y Cajal J, Jimenez MD, Martinez H, Pocovi M, Grande F. Cord blood lipoprotein-cholesterol: relationship birth weight and gestational age of newborns. Metabolism 1989; 38: 435-8.
- Leeson CPM, Kattenhorn M, Morley R, Lucas A, Deanfeald JE. Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation 2001; 103: 1264-8
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Dahili Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 11 Haziran 2010 |
| Yayımlandığı Sayı | Yıl 2010Cilt: 32 Sayı: 2 |