Aspirinin hepatotoksik etkisi ve Reye sendromu

Nergiz Turgut; Tülin Söylemezoğlu

Aspirinin hepatotoksik etkisi ve Reye sendromu

Yıl 2011, Cilt: 33 Sayı: 1, 125 - 132, 14.03.2011

Nergiz Turgut , Tülin Söylemezoğlu

Öz

Özet

Analjeziklerin riskleri ve yararları hakkındaki tartışmalar, analjezikler ilk çıktıklarından beri devam etmektedir. Araştırmacılar hem yeni hem de eskiden denenmiş ve kontrol edilmiş ilaçların, kontrendikasyonlar ve yan tesirler açısından yeniden düzenlemelere maruz kalmaları ile ilgilenmektedir. Bu derlemede, piyasaya giren birçok ilaca karşın halen yaygın olarak kullanılan ve bu gruptaki diğer ilaçlarla değerlendirmek ve karşılaştırmak açısından standart olarak kullanılan aspirinin, hepatotoksik etkisi sunulmaktadır. Ayrıca viral enfeksiyonlar sırasında aspirin kullanılması ile ilişkili olabileceği ileri sürülen, yağlı karaciğer dejenerasyonunun eşlik ettiği bir akut ensefalit olan Reye sendromu sunulmaktadır.

Anahtar sözcükler: Aspirin, salisilat, hepatotoksik etki, Reye sendromu

Abstract

Discussions about the risks and benefits of analgesics have been continuing since the first come out of analgesics. Investigators are interested in new arrangements for contraindications and side effects of both new and previously checked and controlled drugs. In this review, the hepatotoxic effect of aspirin which is currently used widespread besides availability of many drugs in market and also which is used as a standard to evaluate and to compare to other drugs is presented. In addition, Reye's syndrome; an acute encephalopathy accompanied with fatty liver degeneration which suggested to be associated with aspirin usage during viral infections is presented.

Key words: Aspirin, salicylate, hepatotoxic effect, Reye's syndrome

Anahtar Kelimeler

Kaynakça

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