Öz
Abstract
Leptomeningeal metastasis (LMM) occurs in about 3-8% of patients with systemic cancer. It is very rare in patients with signet-ring cell carcinoma. But, the prognosis is also very poor. We report a case of a younger woman with signet-ring cell carcinoma of primary origin unknown who presented with meningeal carcinomatosis.
Keywords: Leptomeningeal metastasis; signet-ring cell carcinoma; prognosis.
Özet
Leptomenengeal metastazlar, sistemik kanserli hastaların yaklaşık %3-8’inde oluşur. Bu, signet-ring hücreli karsinomu olan hastalarda çok nadirdir. Ama, prognoz da çok kötüdür. Meningeal karsinomatozisi olan ve birincil orjini bilinmeyen signet-ring hücreli karsinomu olan genç bir bayan olguyu bildiriyoruz.
Anahtar sözcükler: Leptomeningeal karsinomatozis; taşlı yüzük hücreli karsinom; prognoz.Anahtar Kelimeler
Kaynakça
- Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol 1978; 19: 579-92.
- De Angelis LM. Current diagnosis and treatment of leptomeningeal metastasis. J Neuro- Oncol 1998; 38: 245-52
- De Angelis LM, Boutros D. Leptomeningeal metastasis. Cancer Invest 2005; 23: 145-54.
- Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 1982; 49: 759-72
- Grant R, Naylor B, Greenberg HS, Junck L. Clinical outcome in aggressively treated meningeal carcinomatosis. Arch Neurol 1994; 51: 457-61
- Grossman SA, Krabak MJ. Leptomeningeal carcinomatosis. Cancer Treat Rev 1999; 25: 103-19.
- Kim DY, Lee KW, Yun T, Park SR, Jung JY, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone. Jpn J Clin Oncol 2003; 33: 608-12.
- Fuchizaki U, Ohta H, Kaneko S. Image of the month. Gastric signet-ring-cell carcinoma with leptomeningeal carcinomatosis. Gastroenterology 2005; 128: 1773.
- Lisenko Y, Kumar AJ, Yao J, Ajani J, Ho L. Leptomeningeal carcinomatosis originating from gastric cancer: report of eight cases and review of the literature. Am J Clin Oncol 2003; 26: 165-70.
- Lee JL, Kang YK, Kim TW, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH. Leptomeningeal carcinomatosis in gastric cancer. J Neurooncol 2004; 66: 167-74.
- Lee HG, Lee B, Kim SM, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH. A case of gastric adenocarcinoma presenting as meningeal carcinomatosis. Korean J Intern Med 2007; 22: 304-7.
- Suto C, Oohira A, Funaki C, Kanno S, Mori Y. Pathological findings of optic neuropathy from metastatic leptomeningeal carcinomatosis. Jpn J Ophthalmol 2007; 51: 396-8.
- Wagemakers M, Verhagen W, Borne B, Venderink D, Wauters C, Strobbe L. Bilateral profound hearing loss due to meningeal carcinomatosis. J Clin Neurosci 2005; 12: 315-8.
- Nakatsuji Y, Sadahiro S, Watanabe S, Fujimura H, Abe K, Koguchi K, Sakoda S. Leptomeningeal signet-ring cell carcinomatosis presenting with ophthalmoplegia, areflexia and ataxia. Clin Neuropathol 2001; 20: 272-5.
- Kakar A, Sethi PK, Agarwal CS, Bhalla S, Mahajan M. Leptomeningeal and brain metastasis in a young patient of signet ring cell carcinoma of stomach. J Assoc Physicians India 1998; 46: 320-1.
Öz
Leptomenengeal metastazlar, sistemik kanserli hastaların yaklaşık %3-8’inde oluşur. Bu, signetring hücreli karsinomu olan hastalarda çok nadirdir. Ama prognoz da çok kötüdür. Meningeal karsinomatozisi olan ve birincil orjini bilinmeyen signet-ring hücreli karsinomu olan genç bir bayan olguyu bildiriyoruz
Anahtar Kelimeler
Leptomeningeal karsinomatozis taşlı yüzük hücreli karsinom prognoz
Kaynakça
- Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol 1978; 19: 579-92.
- De Angelis LM. Current diagnosis and treatment of leptomeningeal metastasis. J Neuro- Oncol 1998; 38: 245-52
- De Angelis LM, Boutros D. Leptomeningeal metastasis. Cancer Invest 2005; 23: 145-54.
- Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 1982; 49: 759-72
- Grant R, Naylor B, Greenberg HS, Junck L. Clinical outcome in aggressively treated meningeal carcinomatosis. Arch Neurol 1994; 51: 457-61
- Grossman SA, Krabak MJ. Leptomeningeal carcinomatosis. Cancer Treat Rev 1999; 25: 103-19.
- Kim DY, Lee KW, Yun T, Park SR, Jung JY, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone. Jpn J Clin Oncol 2003; 33: 608-12.
- Fuchizaki U, Ohta H, Kaneko S. Image of the month. Gastric signet-ring-cell carcinoma with leptomeningeal carcinomatosis. Gastroenterology 2005; 128: 1773.
- Lisenko Y, Kumar AJ, Yao J, Ajani J, Ho L. Leptomeningeal carcinomatosis originating from gastric cancer: report of eight cases and review of the literature. Am J Clin Oncol 2003; 26: 165-70.
- Lee JL, Kang YK, Kim TW, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH. Leptomeningeal carcinomatosis in gastric cancer. J Neurooncol 2004; 66: 167-74.
- Lee HG, Lee B, Kim SM, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH. A case of gastric adenocarcinoma presenting as meningeal carcinomatosis. Korean J Intern Med 2007; 22: 304-7.
- Suto C, Oohira A, Funaki C, Kanno S, Mori Y. Pathological findings of optic neuropathy from metastatic leptomeningeal carcinomatosis. Jpn J Ophthalmol 2007; 51: 396-8.
- Wagemakers M, Verhagen W, Borne B, Venderink D, Wauters C, Strobbe L. Bilateral profound hearing loss due to meningeal carcinomatosis. J Clin Neurosci 2005; 12: 315-8.
- Nakatsuji Y, Sadahiro S, Watanabe S, Fujimura H, Abe K, Koguchi K, Sakoda S. Leptomeningeal signet-ring cell carcinomatosis presenting with ophthalmoplegia, areflexia and ataxia. Clin Neuropathol 2001; 20: 272-5.
- Kakar A, Sethi PK, Agarwal CS, Bhalla S, Mahajan M. Leptomeningeal and brain metastasis in a young patient of signet ring cell carcinoma of stomach. J Assoc Physicians India 1998; 46: 320-1.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Olgu Sunumları |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Eylül 2011 |
| Yayımlandığı Sayı | Yıl 2011Cilt: 33 Sayı: 3 |