Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Çiğdem Kader; Sadiye Yolcu; Ayşe Erbay

Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Yıl 2013, Cilt: 35 Sayı: 4, 488 - 494, 20.08.2013

Çiğdem Kader Sadiye Yolcu , Ayşe Erbay

Öz

Abstract

Aim. Brucellosis is a multisystemic infectious disease. An inflammatory process occurs in brucellosis which causes increase in acute phase reactants. Mean platelet volume (MPV) has been shown as an inflammatory marker in some diseases. In this study we searched the MPV levels of brucellosis patients. Method. MPV levels of forty-seven patients with brucellosis were evaluated. Results. We included a total of 47 brucellosis patients having an average age of 47.4±14.6 and sex distribution of 21 (44,7%) male and 26 (55,3%) female and also 47 control healthy subjects having an average age of 45,2±12,3 and sex distribution of 25 (53,2%) male and 22 (46,8%) female). Erythrocte sedimentation rate (ESR), MPV, red cell distribution width (RDW), Hemoglobin (Hgb) and white blood cell(WBC) values in pre-treatment stage were statistically different from after treatment period. MPV levels were significantly lower in the pretreatment group. Similarly RDW values were lower in pretreatment group. MPV levels of patients were not diffrent in the acute and subacute stage. There was not any significant difference in the MPV levels of patients with hepatomegaly and without hepatomegaly (MPV levels of patients with splenomegaly were lower than patients without splenomegaly Spearman’s correlation analysis showed a significant negative correlation between STAT (serum tube agglutination test) and MPV values. Conclusion. MPV levels may be useful in the follow-up of brucellosis patients.

Keywords: Brucellosis, acute phase reactant, mean platelet volume

Özet

Amaç. Bruselloz multisistemik bir enfeksiyon hastalığıdır. Brusellozda akut faz reaktanlarının artmasına neden olan inflamatuar bir süreç izlenmektedir. Mean platelet volume (MPV)’ nin bazı hastalıklarda inflamasyonu gösteren bir değer olduğu gösterilmiştir. Bu çalışmada bruselloz hastalarının MPV düzeylerini araştırmayı amaçladık. Yöntem. Kırkyedi brusella hastasının MPV düzeyleri incelendi. Bulgular. Çalışmamıza yaş ortalaması 47,4±14,6 olan, 21 (%44,7) erkek, 26 (%55,3) kadın,toplam 47 bruselloz hastası ve yaş ortalaması 45,2±12,3 olan 25 (%53,2) erkek, 22 (%46,8) kadından oluşan 47 kişilik kontrol grubu dahil edildi. Tedavi öncesi ve tedavi sonrası eritrosit sedimentasyon hızı (ESR), MPV, red cell distribution width (RDW), hemoglobin (Hgb), beyaz küre (WBC) değerleri arasında istatistiksel olarak anlamlı farklılık mevcuttu. Tedavi öncesi MPV düzeyleri anlamlı olarak düşüktü. Benzer şekilde tedavi öncesi RDW değerlerinde de anlamlı düşüklük saptandı. Akut ve subakut faz arasında MPV düzeyleri açısından farklılık saptanmadı. Hepatomegali olan ve olmayan grupta da MPV düzeyleri açısından belirgin bir fark yoktu. Splenomegalisi olan hastaların MPV düzeyleri splenomegalisi olmayan hastalara göre daha düşük idi. Spearman korelasyonu, STAT (serum tube agglutination test) ve MPV arasında anlamlı negatif bir korelasyon gösterdi. Sonuç. MPV düzeyleri bruselloz hastalarının takibinde kullanışlı bir tetkik olabilir.

Anahtar sözcükler: Bruselloz, akut faz reaktanı, mean platelet volume

Anahtar Kelimeler

Brucellosis, acute phase reactant, mean platelet volume

Kaynakça

1. Young EJ. Brucella species In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6th ed., Philadelphia: Churchill Livingstone 2005; 2669-72.
2. Crosby E, Llosa L, Miro Quesada M, Carrillo C, Gotuzzo E. Hematologic changes in brucellosis. J Infect Dis 1984; 150: 419-24.
3. al-Eissa Y, al-Nasser M. Haematological manifestations of childhood brucellosis. Infection 1993; 21: 23-6.
4. Di Mario A, Sica S, Zini G, Salutari P, Leone G. Microangiopathic hemolytic anemia and severe thrombocytopenia in Brucella infection. Ann Hematol 1995; 70: 59-60.
5. Akdeniz H, Irmak H, Seçkinli T, Buzgan T, Demiröz AP. Hematological manifestations in brucellosis cases in Turkey. Acta Med Okoyama 1998; 52: 63- 5.
6. Gürkan E, Başlamışlı F, Güvenç B, Bozkurt B, Ünsal C. Immune thrombocytopenic purpura associated with brucella and toxoplasma infections. Am J Hematol 2003; 74: 52-4.
7. Farr M, Scott DL, Constable TJ, Hawker RJ, Hawkins CF, Stuart J. Thrombocytosis of active rheumatoid disease. Ann Rheum Dis 1983; 42: 545-9.
8. Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol 2002; 118: 787-93.
9. Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-61.
10. Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, Jordanova N, Christ G, Thalhammer R, Huber K, SunderPlassmann R. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002; 117: 399-404.
11. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE, Kouroumalis EA. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-81.
12. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011; 17: 47-58.
13. Arslan N, Makay B. Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2010; 23: 807-13.
14. Pathansali R, Smith N, Bath P. Altered megakaryocyte-platelet haemostatic axis in hypercholesterolaemia. Platelets 2001; 12: 292-7.
15. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, Lakasas G. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475-8.
16. Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: Effects of amlodipine-based antihypertensive therapy. Ann Med 2004; 36: 552-7.
17. Wang RT, Li Y, Zhu XY, Zhang YN. Increased mean platelet volume is associated with arterial stiffness. Platelets 2012; 22: 447-51.
18. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148-56.
19. Muscari A, Puddu GM, Cenni A, Silvestri MG, Giuzio R, Rosati M, Santoro N, Bianchi G, Magalotti D, Zoli M. Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res 2009; 123: 587-91.
20. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER 3rd. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004. Atherosclerosis 2010; 213: 586-91.
21. Pauling JD, O'Donnell VB, Mchugh NJ. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets 2013; 24: 503-15.
22. Balbaloğlu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets 2013.
23. Öztürk ZA, Sayıner H, Kuyumcu ME. Yeşil Y, Savaş E, Sayıner ZA, Kısacık B, Kepekçi Y. Mean Platelet Volume in Assessment of Brucellosis Disease. Biomed Res-India 2012; 23: 541-6.
24. Küçükbayrak A, Taş T, Tosun M, Aktaş G, Alçelik A, Necati Hakyemez I, Koçoğlu E, Akdeniz H. Could thrombocyte parameters be an inflammatory marker in the brucellosis? Medicinski Glasnik 2013; 10: 35-9.
25. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 2006; 6: 91-9.
26. Gotuzzo E, Celillo E. Brucella in: Gorbach SI, Bartlett JG, Blacklow NR, editors. Infectious diseases. Philadelphia: Harcourt Brace Jovanovich Inc 1992; 1513-8.
27. Hall WH. Brucellosis in: Evans AS, Brachman PS, editors. Bacterial infections of humans. 2nd ed., New York: Plenum Publishing Corp 1991; 133-51.
28. Ariza J. Current diagnosis of brucellosis. Med Clin (Barc) 1992; 98: 494-6.
29. Demirdağ K, Özden M, Kalkan A, Gödekmerdan A, Sırrı Kılıç S. Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers. FEMS Immunol Med Microbiol 2003; 39: 149-53.
30. Dabdoob WA, Abdulla ZA. A panel of eight tests in the serodiagnosis and immunological evaluation of acute brucellosis. East Mediterr Health J 2000; 6: 304-12.
31. Çil H, Yavuz C, İslamoğlu Y, Tekbaş EÖ, Demirtaş S, Atılgan ZA, Gündüz E, Benli ED, Tanrıverdi H. Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis. Clin Appl Thromb Hemost 2012; 18: 650-3.
32. De Luca G, Venegoni L, Iorio S, Secco GG, Cassetti E, Verdoia M, Schaffer A, Coppo L, Bellomo G, Marino P; Novara Atherosclerosis Study Group. Platelet distribution width and the extent of coronary artery disease: Results from a large prospective study. Platelets 2010; 21: 508-14.
33. Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996; 87: 1833-44.
34. Aydoğan T, Kanbay M, Alıcı O, Koşar A. Incidence and etiology of thrombocytosis in an adult Turkish population. Platelets 2006; 17: 328-31.
35. Marwaha N. Thrombocytosis as a predictor of serious bacterial infection. Indian Pediatr 2010; 47: 923-4.
36. Sharda DC, Lubani M. A Study of brucellosis in childhood. Clin Pediatr 1986; 25: 492-5.
37. Yıldırmak Y, Palanduz A, Telhan L, Arapoğlu M, Kayaalp N. Bone marrow hypoplasia during Brucella infection. J Pediatr Hematol Oncology 2003; 25: 63- 4.
38. Aysha MH, Shayib MA. Pancytopenia and other haematological findings in brucellosis. Scand J Haematol 1986; 36: 335-8.
39. Citak EC, Citak FE, Tanyeri B, Arman D. Hematologic manifestations of brucellosis in children: 5 years experience of an Anatolian center. J Pediatr Hematol Oncology 2010; 32: 137-40.
40. Akbayram S, Doğan M, Akgün C, Peker E, Parlak M, Öner AF. An analysis of children with brucellosis associated with isolated thrombocytopenia. Clin Appl Thromb Hemost 2011; 17: 36-8.
41. Catal F, Bavbek N, Bayrak O, Uz E, Işık B, Karabel M, Değirmencioğlu H, Mete E, Akçay A. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail 2008; 30: 377-81.
42. Senaran H, İleri M, Altınbaş A, Koşar A, Yetkin E, Öztürk M, Karaaslan Y, Kirazlı S. Thrombopoietin and mean platelet volume in coronary artery disease. Clin Cardiol 2001; 24: 405-8.
43. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-60.
44. Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R, Edmonds M, Martin JF, Erusalimsky JD. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997; 17: 802-7.
45. Akbulut H, Çelik İ, Akbulut A. Cytokine levels in patients with brucellosis and their relations with the treatment. Indian J Med Microbiol 2007; 25: 387-90.
46. Yüksel O, Helvacı K, Başar O, Köklü S, Caner S, Helvacı N, Abaylı E, Altıparmak E. An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume. Platelets 2009; 20: 277-81.
47. Karpatkin S. Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets. J Clin Invest 1969; 48: 1083-7.

Bruselloz hastalarında ortalama trombosit hacmi (MPV) düzeylerinin değerlendirilmesi

Yıl 2013, Cilt: 35 Sayı: 4, 488 - 494, 20.08.2013

Çiğdem Kader Sadiye Yolcu , Ayşe Erbay

Öz

Amaç. Bruselloz multisistemik bir enfeksiyon hastalığıdır. Brusellozda akut faz reaktanlarının
artmasına neden olan inflamatuar bir süreç izlenmektedir. Mean platelet volume (MPV)’ nin bazı
hastalıklarda inflamasyonu gösteren bir değer olduğu gösterilmiştir. Bu çalışmada bruselloz
hastalarının MPV düzeylerini araştırmayı amaçladık. Yöntem. Kırkyedi brusella hastasının MPV
düzeyleri incelendi. Bulgular. Çalışmamıza yaş ortalaması 47,4±14,6 olan, 21 (%44,7) erkek, 26
(%55,3) kadın,toplam 47 bruselloz hastası ve yaş ortalaması 45,2±12,3 olan 25 (%53,2) erkek, 22
(%46,8) kadından oluşan 47 kişilik kontrol grubu dahil edildi. Tedavi öncesi ve tedavi sonrası
eritrosit sedimentasyon hızı (ESR), MPV, red cell distribution width (RDW), hemoglobin (Hgb),
beyaz küre (WBC) değerleri arasında istatistiksel olarak anlamlı farklılık mevcuttu. Tedavi öncesi
MPV düzeyleri anlamlı olarak düşüktü. Benzer şekilde tedavi öncesi RDW değerlerinde de
anlamlı düşüklük saptandı. Akut ve subakut faz arasında MPV düzeyleri açısından farklılık
saptanmadı. Hepatomegali olan ve olmayan grupta da MPV düzeyleri açısından belirgin bir fark
yoktu. Splenomegalisi olan hastaların MPV düzeyleri splenomegalisi olmayan hastalara göre daha
düşük idi. Spearman korelasyonu, STAT (serum tube agglutination test) ve MPV arasında anlamlı
negatif bir korelasyon gösterdi. Sonuç. MPV düzeyleri bruselloz hastalarının takibinde kullanışlı
bir tetkik olabilir

Anahtar Kelimeler

Bruselloz, akut faz reaktanı, mean platelet volume

Kaynakça

1. Young EJ. Brucella species In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 6th ed., Philadelphia: Churchill Livingstone 2005; 2669-72.
2. Crosby E, Llosa L, Miro Quesada M, Carrillo C, Gotuzzo E. Hematologic changes in brucellosis. J Infect Dis 1984; 150: 419-24.
3. al-Eissa Y, al-Nasser M. Haematological manifestations of childhood brucellosis. Infection 1993; 21: 23-6.
4. Di Mario A, Sica S, Zini G, Salutari P, Leone G. Microangiopathic hemolytic anemia and severe thrombocytopenia in Brucella infection. Ann Hematol 1995; 70: 59-60.
5. Akdeniz H, Irmak H, Seçkinli T, Buzgan T, Demiröz AP. Hematological manifestations in brucellosis cases in Turkey. Acta Med Okoyama 1998; 52: 63- 5.
6. Gürkan E, Başlamışlı F, Güvenç B, Bozkurt B, Ünsal C. Immune thrombocytopenic purpura associated with brucella and toxoplasma infections. Am J Hematol 2003; 74: 52-4.
7. Farr M, Scott DL, Constable TJ, Hawker RJ, Hawkins CF, Stuart J. Thrombocytosis of active rheumatoid disease. Ann Rheum Dis 1983; 42: 545-9.
8. Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol 2002; 118: 787-93.
9. Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-61.
10. Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, Jordanova N, Christ G, Thalhammer R, Huber K, SunderPlassmann R. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002; 117: 399-404.
11. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE, Kouroumalis EA. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-81.
12. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011; 17: 47-58.
13. Arslan N, Makay B. Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2010; 23: 807-13.
14. Pathansali R, Smith N, Bath P. Altered megakaryocyte-platelet haemostatic axis in hypercholesterolaemia. Platelets 2001; 12: 292-7.
15. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, Lakasas G. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475-8.
16. Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: Effects of amlodipine-based antihypertensive therapy. Ann Med 2004; 36: 552-7.
17. Wang RT, Li Y, Zhu XY, Zhang YN. Increased mean platelet volume is associated with arterial stiffness. Platelets 2012; 22: 447-51.
18. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148-56.
19. Muscari A, Puddu GM, Cenni A, Silvestri MG, Giuzio R, Rosati M, Santoro N, Bianchi G, Magalotti D, Zoli M. Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res 2009; 123: 587-91.
20. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER 3rd. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004. Atherosclerosis 2010; 213: 586-91.
21. Pauling JD, O'Donnell VB, Mchugh NJ. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets 2013; 24: 503-15.
22. Balbaloğlu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets 2013.
23. Öztürk ZA, Sayıner H, Kuyumcu ME. Yeşil Y, Savaş E, Sayıner ZA, Kısacık B, Kepekçi Y. Mean Platelet Volume in Assessment of Brucellosis Disease. Biomed Res-India 2012; 23: 541-6.
24. Küçükbayrak A, Taş T, Tosun M, Aktaş G, Alçelik A, Necati Hakyemez I, Koçoğlu E, Akdeniz H. Could thrombocyte parameters be an inflammatory marker in the brucellosis? Medicinski Glasnik 2013; 10: 35-9.
25. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 2006; 6: 91-9.
26. Gotuzzo E, Celillo E. Brucella in: Gorbach SI, Bartlett JG, Blacklow NR, editors. Infectious diseases. Philadelphia: Harcourt Brace Jovanovich Inc 1992; 1513-8.
27. Hall WH. Brucellosis in: Evans AS, Brachman PS, editors. Bacterial infections of humans. 2nd ed., New York: Plenum Publishing Corp 1991; 133-51.
28. Ariza J. Current diagnosis of brucellosis. Med Clin (Barc) 1992; 98: 494-6.
29. Demirdağ K, Özden M, Kalkan A, Gödekmerdan A, Sırrı Kılıç S. Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers. FEMS Immunol Med Microbiol 2003; 39: 149-53.
30. Dabdoob WA, Abdulla ZA. A panel of eight tests in the serodiagnosis and immunological evaluation of acute brucellosis. East Mediterr Health J 2000; 6: 304-12.
31. Çil H, Yavuz C, İslamoğlu Y, Tekbaş EÖ, Demirtaş S, Atılgan ZA, Gündüz E, Benli ED, Tanrıverdi H. Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis. Clin Appl Thromb Hemost 2012; 18: 650-3.
32. De Luca G, Venegoni L, Iorio S, Secco GG, Cassetti E, Verdoia M, Schaffer A, Coppo L, Bellomo G, Marino P; Novara Atherosclerosis Study Group. Platelet distribution width and the extent of coronary artery disease: Results from a large prospective study. Platelets 2010; 21: 508-14.
33. Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996; 87: 1833-44.
34. Aydoğan T, Kanbay M, Alıcı O, Koşar A. Incidence and etiology of thrombocytosis in an adult Turkish population. Platelets 2006; 17: 328-31.
35. Marwaha N. Thrombocytosis as a predictor of serious bacterial infection. Indian Pediatr 2010; 47: 923-4.
36. Sharda DC, Lubani M. A Study of brucellosis in childhood. Clin Pediatr 1986; 25: 492-5.
37. Yıldırmak Y, Palanduz A, Telhan L, Arapoğlu M, Kayaalp N. Bone marrow hypoplasia during Brucella infection. J Pediatr Hematol Oncology 2003; 25: 63- 4.
38. Aysha MH, Shayib MA. Pancytopenia and other haematological findings in brucellosis. Scand J Haematol 1986; 36: 335-8.
39. Citak EC, Citak FE, Tanyeri B, Arman D. Hematologic manifestations of brucellosis in children: 5 years experience of an Anatolian center. J Pediatr Hematol Oncology 2010; 32: 137-40.
40. Akbayram S, Doğan M, Akgün C, Peker E, Parlak M, Öner AF. An analysis of children with brucellosis associated with isolated thrombocytopenia. Clin Appl Thromb Hemost 2011; 17: 36-8.
41. Catal F, Bavbek N, Bayrak O, Uz E, Işık B, Karabel M, Değirmencioğlu H, Mete E, Akçay A. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail 2008; 30: 377-81.
42. Senaran H, İleri M, Altınbaş A, Koşar A, Yetkin E, Öztürk M, Karaaslan Y, Kirazlı S. Thrombopoietin and mean platelet volume in coronary artery disease. Clin Cardiol 2001; 24: 405-8.
43. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-60.
44. Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R, Edmonds M, Martin JF, Erusalimsky JD. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997; 17: 802-7.
45. Akbulut H, Çelik İ, Akbulut A. Cytokine levels in patients with brucellosis and their relations with the treatment. Indian J Med Microbiol 2007; 25: 387-90.
46. Yüksel O, Helvacı K, Başar O, Köklü S, Caner S, Helvacı N, Abaylı E, Altıparmak E. An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume. Platelets 2009; 20: 277-81.
47. Karpatkin S. Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets. J Clin Invest 1969; 48: 1083-7.

Toplam 47 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Bölüm	Dahili Tıp Bilimleri Araştırma Yazıları
Yazarlar	Çiğdem Kader Sadiye Yolcu Ayşe Erbay
Yayımlanma Tarihi	20 Ağustos 2013
Yayımlandığı Sayı	Yıl 2013Cilt: 35 Sayı: 4

Kaynak Göster

AMA	Kader Ç, Yolcu S, Erbay A. Evaluation of mean platelet volume (MPV) levels in brucellosis patients. CMJ. Aralık 2013;35(4):488-494.

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