Araştırma Makalesi
Induction of oxidative/nitrosative stress following Tc-99m pertechnetate thyroid scintigraphy in human
Öz
Objective: Oxidative/nitrosative stress may be triggered by a
various sources and ionizing radiation may also initiate oxidative/nitrosative
stress.
This is the first study, we aimed to investigate the
induction of oxidative and nitrosative stress due to ionizing radiation in
patients undergoing Tc-99m pertechnetate thyroid scintigraphy.
Method: Totally 26 patients (16 female,10 male) undergoing
Tc-99m pertechnetate thyroid scintigraphy were included in this study. The
patients were aged between 20 and 50
years (58.0±16.3 years). The blood samples were taken from patients 20
minutes after intravenous
injection of Tc-99m pertechnetate in dose used clinically (5 miliCurie) before
the patients were taken to the thyroid imaging. Control group was selected from
30 healthy subjects (15 female,15 male). The control group was aged between 17
and 72 years (57.0±14.0 years). The blood samples were taken both patients and
control group for measuring antioxidant enzymes (catalase and superoxide
dismutase), malondialdehyde, nitric oxide and nitrotyrosine as
oxidative/nitrosative stress biomarkers.
Results: In this study we found that activities of antioxidant
enzymes inreased in patients compared to control (p<0.05). Further,
malondialdehyde levels as an indicator of oxidative stress were higher in
patients than control group (p<0.05).The levels of nitric oxide and
nitrotyrosine as nitrosative stress biomarkers also increased in patients
compared to control groups (p<0.05).
Conclusions:
We
thought that Tc-99m pertechnetate may cause an increase in reactive oxygen and
nitrogen species and may cause oxidative/nitrosative damage at the cellular
level. Our results indicated that the dose of Tc-99m pertechnetate given in
these patients undergoing thyroid scintigraphy can tolerable.
Anahtar Kelimeler
Radiation Nuclear medicine Oxidative and nitrosative stress Thyroid scintigraphy
Kaynakça
- 1. Harjeet A, Sahni D, Jit I, Aggarwal AK. Shape, measurements and weight of the thyroid gland in northwest Indians. Surg Radiol Anat. 2004;26:91-5.
- 2. Smith JR, Oates E. Radionuclide imaging of the thyroid gland: patterns, pearls, and pitfalls. Clin Nucl Med. 2004;29:181-193.
- 3. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44-84.
- 4. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016;15:71.
- 5. Kurutas EB, Ozturk P. The evaluation of local oxidative/nitrosative stress in patients with pityriasis versicolor: a preliminary study. Mycoses. 2016;59:720-725.
- 6. Georgieva S, Popov B, Bonev G. Radioprotective effect of Haberlea rhodopensis (Friv.) leaf extract on gamma-radiation-induced DNA damage, lipid peroxidation and antioxidant levels in rabbit blood. Indian J Exp Biol. 2013;5129-36.
- 7. Azab KS, Bashandy M, Salem M, Ahmed O, Tawfik Z, Helal H. Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats. N Am J Med Sci. 2011;3:268-76.
- 8. Georgeson GD, Szony BJ, Streitman K, Varga IS, Kovács A, Kovács L, et al. Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section. Eur J Obstet Gynecol Reprod Biol. 2002;103:136-9.
- 9. Akman SA, Forrest G, Chu FF, Doroshow JH. Resistance to hydrogen peroxide associated with altered catalase mRNA stability in MCF7 breast cancer cells. Biochim Biophys Acta. 1989;1009:70-4.
- 10. Beckman JS, Crow JP. Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem Soc Trans. 1993;21:330-4.
- 11. Beutler E. Red Cell Metabolism. A Manual of Biochemical Methods. 2nd ed. New York: Grune and Stratton Inc; 1984. p. 68-70.
- 12. Fridovich I. Superoxide dismutase. Adv Enzymol 1974;41:35-97.
- 13. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8.
- 14. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem. 1990;36:1440-3.
- 15. Karbownik M, Reiter RJ. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med. 2000;225:9-22.
- 16. Daniels GH. Radioactive iodine: a slice of history. Thyroid. 2013;23:253-258.
- 17. Wong KK, Gandhi A, Viglianti BL, Fig LM, Rubello D, Gross MD. Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography. World J Radiol. 2016;8:635-55.
- 18. Sarkar SD. Benign thyroid disease: what is the role of nuclear medicine? Semin Nucl Med. 2006;36:185-93.
- 19. Intenzo CM, dePapp AE, Jabbour S, Miller JL, Kim SM, Capuzzi DM. Scintigraphic manifestations of thyrotoxicosis. Radiographics. 2003;23: 857-69.
- 20. Wong KK, Fig LM, Youssef E, Ferretti A, Rubello D, Gross MD. Endocrine scintigraphy with hybrid SPECT/CT. Endocr Rev. 2014;35:717-46.
- 21. Subramanyam P, Palaniswamy SS. Pictorial essay of developmental thyroid anomalies identified by Technetium thyroid scintigraphy. Indian J Nucl Med. 2015 ;30:323-7.
- 22. Leslie WD, Dupont JO, Bybel B, Riese KT. Parathyroid 99mTc-sestamibi scintigraphy: dual-tracer subtraction is superior to double-phase washout. Eur J Nucl Med Mol Imaging. 2002;29:1566-70.
- 23. Lin DS. Thyroid imaging - mediastinal uptake in thyroid imaging. Semin Nucl Med. 1983;13:395-6.
- 24. Schoen EJ, Clapp W, To TT, Fireman BH. The key role of newborn thyroid scintigraphy with isotopic iodide (123I) in defining and managing congenital hypothyroidism. Pediatrics. 2004;114:e683- 688.
- 25. Ruchala M, Szczepanek E, Sowinski J. Diagnostic value of radionuclide scanning and ultrasonography in thyroid developmental anomaly imaging. Nucl Med Rev Cent East Eur. 2011;14:21-8.
- 26. Shahin S, Banerjee S, Singh SP, Chaturvedi CM. 2.45 GHz Microwave radiation impairs learning and spatial memory oxidative/nitrosative stress induced p53-dependent/independent hippocampal apoptosis: molecular basis and underlying mechanism. Toxicol Sci. 2015;148:380-99.
- 27. Lee JH, Choi IY, Kil IS, Kim SY, Yang ES, Park JW. Protective role of superoxide dismutases against ionizing radiation in yeast. Biochim Biophys Acta. 2001;1526:191-8.
- 28. van Ginkel G, Sevanian A. Lipid peroxidation-induced membrane structural alterations. In L. P. B. T.-M. in Enzymology (Ed.), 1994; Oxygen Radicals in Biological Systems Part C (Vol. 233: 273-288). Academic Pres.
- 29. Abdel-Shafi S, Saad TMM, MEF Abdel-Haliem, Ghonemey ARMA, Enan G. Radioprotective Role of Some Bacteria Belonging to Actinomycetales against Gamma Irradiation-Induced Oxidative Stress in Male Albino Rats. Egypt J H Med. 2016;64:364- 372.
- 30. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol. 1996;271:C1424-C1437.
Yıl 2019,
Cilt: 41 Sayı: 3, 592 - 598, 30.09.2019
Öz
Kaynakça
- 1. Harjeet A, Sahni D, Jit I, Aggarwal AK. Shape, measurements and weight of the thyroid gland in northwest Indians. Surg Radiol Anat. 2004;26:91-5.
- 2. Smith JR, Oates E. Radionuclide imaging of the thyroid gland: patterns, pearls, and pitfalls. Clin Nucl Med. 2004;29:181-193.
- 3. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44-84.
- 4. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016;15:71.
- 5. Kurutas EB, Ozturk P. The evaluation of local oxidative/nitrosative stress in patients with pityriasis versicolor: a preliminary study. Mycoses. 2016;59:720-725.
- 6. Georgieva S, Popov B, Bonev G. Radioprotective effect of Haberlea rhodopensis (Friv.) leaf extract on gamma-radiation-induced DNA damage, lipid peroxidation and antioxidant levels in rabbit blood. Indian J Exp Biol. 2013;5129-36.
- 7. Azab KS, Bashandy M, Salem M, Ahmed O, Tawfik Z, Helal H. Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats. N Am J Med Sci. 2011;3:268-76.
- 8. Georgeson GD, Szony BJ, Streitman K, Varga IS, Kovács A, Kovács L, et al. Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section. Eur J Obstet Gynecol Reprod Biol. 2002;103:136-9.
- 9. Akman SA, Forrest G, Chu FF, Doroshow JH. Resistance to hydrogen peroxide associated with altered catalase mRNA stability in MCF7 breast cancer cells. Biochim Biophys Acta. 1989;1009:70-4.
- 10. Beckman JS, Crow JP. Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem Soc Trans. 1993;21:330-4.
- 11. Beutler E. Red Cell Metabolism. A Manual of Biochemical Methods. 2nd ed. New York: Grune and Stratton Inc; 1984. p. 68-70.
- 12. Fridovich I. Superoxide dismutase. Adv Enzymol 1974;41:35-97.
- 13. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8.
- 14. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem. 1990;36:1440-3.
- 15. Karbownik M, Reiter RJ. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med. 2000;225:9-22.
- 16. Daniels GH. Radioactive iodine: a slice of history. Thyroid. 2013;23:253-258.
- 17. Wong KK, Gandhi A, Viglianti BL, Fig LM, Rubello D, Gross MD. Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography. World J Radiol. 2016;8:635-55.
- 18. Sarkar SD. Benign thyroid disease: what is the role of nuclear medicine? Semin Nucl Med. 2006;36:185-93.
- 19. Intenzo CM, dePapp AE, Jabbour S, Miller JL, Kim SM, Capuzzi DM. Scintigraphic manifestations of thyrotoxicosis. Radiographics. 2003;23: 857-69.
- 20. Wong KK, Fig LM, Youssef E, Ferretti A, Rubello D, Gross MD. Endocrine scintigraphy with hybrid SPECT/CT. Endocr Rev. 2014;35:717-46.
- 21. Subramanyam P, Palaniswamy SS. Pictorial essay of developmental thyroid anomalies identified by Technetium thyroid scintigraphy. Indian J Nucl Med. 2015 ;30:323-7.
- 22. Leslie WD, Dupont JO, Bybel B, Riese KT. Parathyroid 99mTc-sestamibi scintigraphy: dual-tracer subtraction is superior to double-phase washout. Eur J Nucl Med Mol Imaging. 2002;29:1566-70.
- 23. Lin DS. Thyroid imaging - mediastinal uptake in thyroid imaging. Semin Nucl Med. 1983;13:395-6.
- 24. Schoen EJ, Clapp W, To TT, Fireman BH. The key role of newborn thyroid scintigraphy with isotopic iodide (123I) in defining and managing congenital hypothyroidism. Pediatrics. 2004;114:e683- 688.
- 25. Ruchala M, Szczepanek E, Sowinski J. Diagnostic value of radionuclide scanning and ultrasonography in thyroid developmental anomaly imaging. Nucl Med Rev Cent East Eur. 2011;14:21-8.
- 26. Shahin S, Banerjee S, Singh SP, Chaturvedi CM. 2.45 GHz Microwave radiation impairs learning and spatial memory oxidative/nitrosative stress induced p53-dependent/independent hippocampal apoptosis: molecular basis and underlying mechanism. Toxicol Sci. 2015;148:380-99.
- 27. Lee JH, Choi IY, Kil IS, Kim SY, Yang ES, Park JW. Protective role of superoxide dismutases against ionizing radiation in yeast. Biochim Biophys Acta. 2001;1526:191-8.
- 28. van Ginkel G, Sevanian A. Lipid peroxidation-induced membrane structural alterations. In L. P. B. T.-M. in Enzymology (Ed.), 1994; Oxygen Radicals in Biological Systems Part C (Vol. 233: 273-288). Academic Pres.
- 29. Abdel-Shafi S, Saad TMM, MEF Abdel-Haliem, Ghonemey ARMA, Enan G. Radioprotective Role of Some Bacteria Belonging to Actinomycetales against Gamma Irradiation-Induced Oxidative Stress in Male Albino Rats. Egypt J H Med. 2016;64:364- 372.
- 30. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol. 1996;271:C1424-C1437.
Toplam 30 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Medical Science Research Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Eylül 2019 |
| Kabul Tarihi | 25 Eylül 2019 |
| Yayımlandığı Sayı | Yıl 2019Cilt: 41 Sayı: 3 |