Cancer
is the main cause of death and morbidity worldwide. Among females, breast
cancer is the most commonly diagnosed and the leading cause of cancer-related
death. Despite an improvement in the treatment of cancer in the latest years,
metastatic breast cancer treatment success is not at a desirable level. Plants
have huge potential to endow us with noble drugs and current drugs of plant
origin are important part of cancer chemotherapy. The aim of this study was to
evaluate the antiproliferative activity of wheat germ oil in MCF-7 breast cancer
cell line. Antiproliferative
activity and apoptotic effect of wheat germ oil were examined using the XTT
and flow cytometry assay, respectively. According to the XTT results, at concentrations
greater than 0.5 mg/mL, wheat germ oil displayed significant antiproliferative
activity in MCF-7 cells in a dose-dependent manner. The Annexin V binding assay
results also demonstrated that the IC50 concentration of wheat germ oil
increased early and late apoptotic populations (p < 0.05). Though further
studies are required to
specifically identify compounds involved in the anticancer activity of wheat
germ oil, our findings demonstrate that wheat germ oil inhibits proliferation
of MCF-7 cells and its action is dose-dependent.
Birincil Dil | İngilizce |
---|---|
Konular | Sağlık Kurumları Yönetimi |
Bölüm | Medical Science Research Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 30 Eylül 2019 |
Kabul Tarihi | 30 Eylül 2019 |
Yayımlandığı Sayı | Yıl 2019Cilt: 41 Sayı: 3 |