Araştırma Makalesi
The effect of Wireless (Wi-Fi) electromagnetic fields on oxidative stress in rat kidney tissues: A biophysical analysis
Öz
The aim is to investigate the effect of melatonin on oxidative damage in rats exposed to Wi-Fi. This study aims to evaluate the effects of Wriless waves biophysically and biochemically. This study was to investigate the effects of Wi-Fi electromagnetic field (Wi-Fi-EMF) on total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in various rat tissues. In this study, we used 30 male Wistar Albino rats of 230-250 grams of body weight. Animals were divided into five groups as control, saline (1 ml/kg/day olive oil for 30 days), Wi-Fi (12 hours/day for 30 days), melatonin (10 mg/kg/day for 30 days) and melatonin + Wi-Fi (10 mg/kg/day + 12 hours/day for 30 days). In thirtieth day, thirty min after the last drugs administration at the indicated doses, PTZ was administered 45 mg / kg to induce epileptic seizure. The animals were observed for 30 min. Seizure stages (according to the Racine Scale) and first myoclonic jerk times (FMJ). Twenty four hours after PTZ injection, kidney tissuss were collected for biochemical evaluation. Oxidative stress markers (total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)) were measured in kidney tissues. In the control, no electromagnetic wireless exposure was applied. The quantities of TAS, TOS and oxidative stress index (OSI) in the collected kidney tissues were compared between the control and the exposure groups. Wi-Fi reduced antioxidant effect of melatonin (p<0.05). Moreover, Wi-Fi increased cell damage in kidney tissue (p<0.05). In terms of each parameter that is indicative for antioxidant levels and oxidant activity, there were significant differences between kidney tissues (P < 0.05). This is a original study, due to the fact that by revealing in length the Wi-Fi effects of oxidative damage on kidney tissues of rats. Wi-Fi studies show that Wi-Fi causes oxidative stress and apoptosis. Wi-Fi directly reduced the effect of melotonin. The effects of Wi-Fi are caused by oxidative means.
Anahtar Kelimeler
Biophysics model Electromagnetic waves Wi-Fi Rat TAS TOS OSI
Destekleyen Kurum
yok
Proje Numarası
yok
Teşekkür
-
Kaynakça
- 1. Maes A, Verschaeve L, Arroyo A, De WC, Vercruyssen L. In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes, Bioelectromagnetics 1993;14: 495–501. 2. D’Ambrosio G, Lioi M, Scarfi M, Zeni O. Genotoxic effects of amplitude-modulated microwaves on human lymphocytes exposed in vitro under controlled conditions, Electro-Magnetobiol. 1995; 14: 157–164.
- 3. Durna Dastan S, Soylu S, Pence HH, Uyanık B, Duman M, Kurt A, Daştan T, Zılan A, Turan M. Hazardous Genomic Bioeffects of Home Wi-Fi Systems. Neuroquantology. 2018; 16(11): 172-179.
- 4. Garaj-Vrhovac V, Vojvodic S, Fue A, Kubelka D. Effects of 415 MHz frequency on human lymphocyte genome, in: IRPA9 Congress, Proceedings of IRPA9 Congress 3, IRPA, Vienna, 1996, pp. 604–606. 5. Vijayalaxmi BZ, Leal ML, Meltz WF, Pickard KS, Bisht JL, Roti R, Straube WL, Moros EG. Cytogenetic studies in human blood lymphocytes exposed in vitro to radiofrequency radiation at a cellular telephone frequency (835.62 MHz, FDMA), Radiat. Res. 2001;155: 113–121.
- 6. Kocyigit UM, Taslimi P, Gurses F, Soylu S, Durna Daştan S, Gulcin I. The effects of electromagnetics fields on the activities of carbonic anhydrase and acetylcolinesterase enzymes in various tissues of rats. J. Biochem Mol Toxicol. 2018;32:e22031. https://doi.org/10.1002/jbt.22031
- 7. Durna Dastan S, Taslimi P, Gurses F, Akkaya R, Gökalp F, Gulcin İ. The Effects of Wireless on Carbonic Anhydrase and Acetylcholinesterase Enzyme Activities in Some Tissues Related to Respiratory, Excretory and Reproductive Systems of Rats. Cumhuriyet Medical Journal, 2018…(BU KAYNAK EKSİKLİKLER YAZ…
- 8. Seyhan N, Guler G. Review of in vivo static and ELF electric fields studies performed at Gazi Biophysics Department. Electromagn. Biol. Med. 2006; 25:307–323.
- 9. Shehu A, Mohammed A, Magaji RA, Muhammad MS. Exposure to mobile phone electromagnetic field radiation, ringtone and vibration affects anxiety-like behaviour and oxidative stress biomarkers in albino wistar rats. Metab Brain Dis. 2016; 31:355–362. DOI 10.1007/s11011-015-9758-x
- 10. Akpinar D, Ozturk N, Ozen S, Agar A, Yargicoglu P. The effect of different strengths of extremely lowfrequency electric fields on antioxidant status, lipid peroxidation, and visual evoked potentials. Electromagnetic Biology and Medicine, 2012; 31:4, 436-448, DOI: 10.3109/15368378.2012.692342
- 11. Benov LC, Antonov P A, Ribarov S R. Oxidative damage of the membrane lipids after electroporation. Gen. Physiol. Biophys. 1994; 13:85–97.
- 12. Cossarizza A, Capri M, Salvioli S, et al. Electromagnetic fields affect cell proliferation and cytokine production in human cells. In: Blank, M. Electricity and Magnetism in Biology and Medicine. 1993; San Francisco Press. pp. 640–642.
- 13. Guler G, Atalay NS. Changes in hydroxyproline levels in electric field tissue interaction. Ind. J. Biochem. Biophys. 1996;33:531–533.
- 14. Guler G, Atalay NS, Ozogul C, et al. Biochemical and structural approach to collagen synthesis under electric fields. Gen. Physiol. Biophys. 1996; 15:429–440.
- 15. Guler G, Atalay NS. Functional enzymes of liver, total blood protein and albumin levels under electric fields. Med. Biol. Eng. Comput. Suppl. 1997; 1:45.
- 16. Abdus-salam A, Elumelu T, Adenipekun A. Mobile phone radiation and the risk of cancer; a review. Afr J Med Med Sci. 2008 ;37(2):107-18.
- 17. Hidisoglu E, Kantar Gok D, Er H, Akpinar D, Uysal F, Akkoyunlu G, Ozen S, Agar A, Yargicoglu P. 2100-MHz electromagnetic fields havedifferent effects onvisualevokedpotentialsandoxidant/ antioxidant statusdependingonexposureduration. Brain Research 1635. 2016; 1-11.
- 18. Watanabe Y, Nakagawa M, Miyakoshi Y. Enhancement of lipid peroxidation in the liver of mice exposed to magnetic fields. Ind. Health. 1997; 35:285–290.
- 19. Yokus B, Cakir DU, Akdag MZ. et al. Oxidative DNA damage in rats exposed to extremely low frequency electro magnetic fields. Free Radic. Res. 2005; 39:317–323.
- 20. Bediz CS, Baltaci AK, Mogulkoc R, et al. Zinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brain. Tohoku J. Exp. Med. 2006; 208:133–140.
- 21. Guler G, Seyhan N, Aricioglu A. Effects of static and 50 Hz alternating electric fields on superoxide dismutase activity and TBARS levels in guinea pigs. Gen. Physiol. Biophys. 2006. 25:177–193.
Yıl 2020,
Cilt: 42 Sayı: 1, 39 - 43, 20.05.2020
Öz
Proje Numarası
yok
Kaynakça
- 1. Maes A, Verschaeve L, Arroyo A, De WC, Vercruyssen L. In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes, Bioelectromagnetics 1993;14: 495–501. 2. D’Ambrosio G, Lioi M, Scarfi M, Zeni O. Genotoxic effects of amplitude-modulated microwaves on human lymphocytes exposed in vitro under controlled conditions, Electro-Magnetobiol. 1995; 14: 157–164.
- 3. Durna Dastan S, Soylu S, Pence HH, Uyanık B, Duman M, Kurt A, Daştan T, Zılan A, Turan M. Hazardous Genomic Bioeffects of Home Wi-Fi Systems. Neuroquantology. 2018; 16(11): 172-179.
- 4. Garaj-Vrhovac V, Vojvodic S, Fue A, Kubelka D. Effects of 415 MHz frequency on human lymphocyte genome, in: IRPA9 Congress, Proceedings of IRPA9 Congress 3, IRPA, Vienna, 1996, pp. 604–606. 5. Vijayalaxmi BZ, Leal ML, Meltz WF, Pickard KS, Bisht JL, Roti R, Straube WL, Moros EG. Cytogenetic studies in human blood lymphocytes exposed in vitro to radiofrequency radiation at a cellular telephone frequency (835.62 MHz, FDMA), Radiat. Res. 2001;155: 113–121.
- 6. Kocyigit UM, Taslimi P, Gurses F, Soylu S, Durna Daştan S, Gulcin I. The effects of electromagnetics fields on the activities of carbonic anhydrase and acetylcolinesterase enzymes in various tissues of rats. J. Biochem Mol Toxicol. 2018;32:e22031. https://doi.org/10.1002/jbt.22031
- 7. Durna Dastan S, Taslimi P, Gurses F, Akkaya R, Gökalp F, Gulcin İ. The Effects of Wireless on Carbonic Anhydrase and Acetylcholinesterase Enzyme Activities in Some Tissues Related to Respiratory, Excretory and Reproductive Systems of Rats. Cumhuriyet Medical Journal, 2018…(BU KAYNAK EKSİKLİKLER YAZ…
- 8. Seyhan N, Guler G. Review of in vivo static and ELF electric fields studies performed at Gazi Biophysics Department. Electromagn. Biol. Med. 2006; 25:307–323.
- 9. Shehu A, Mohammed A, Magaji RA, Muhammad MS. Exposure to mobile phone electromagnetic field radiation, ringtone and vibration affects anxiety-like behaviour and oxidative stress biomarkers in albino wistar rats. Metab Brain Dis. 2016; 31:355–362. DOI 10.1007/s11011-015-9758-x
- 10. Akpinar D, Ozturk N, Ozen S, Agar A, Yargicoglu P. The effect of different strengths of extremely lowfrequency electric fields on antioxidant status, lipid peroxidation, and visual evoked potentials. Electromagnetic Biology and Medicine, 2012; 31:4, 436-448, DOI: 10.3109/15368378.2012.692342
- 11. Benov LC, Antonov P A, Ribarov S R. Oxidative damage of the membrane lipids after electroporation. Gen. Physiol. Biophys. 1994; 13:85–97.
- 12. Cossarizza A, Capri M, Salvioli S, et al. Electromagnetic fields affect cell proliferation and cytokine production in human cells. In: Blank, M. Electricity and Magnetism in Biology and Medicine. 1993; San Francisco Press. pp. 640–642.
- 13. Guler G, Atalay NS. Changes in hydroxyproline levels in electric field tissue interaction. Ind. J. Biochem. Biophys. 1996;33:531–533.
- 14. Guler G, Atalay NS, Ozogul C, et al. Biochemical and structural approach to collagen synthesis under electric fields. Gen. Physiol. Biophys. 1996; 15:429–440.
- 15. Guler G, Atalay NS. Functional enzymes of liver, total blood protein and albumin levels under electric fields. Med. Biol. Eng. Comput. Suppl. 1997; 1:45.
- 16. Abdus-salam A, Elumelu T, Adenipekun A. Mobile phone radiation and the risk of cancer; a review. Afr J Med Med Sci. 2008 ;37(2):107-18.
- 17. Hidisoglu E, Kantar Gok D, Er H, Akpinar D, Uysal F, Akkoyunlu G, Ozen S, Agar A, Yargicoglu P. 2100-MHz electromagnetic fields havedifferent effects onvisualevokedpotentialsandoxidant/ antioxidant statusdependingonexposureduration. Brain Research 1635. 2016; 1-11.
- 18. Watanabe Y, Nakagawa M, Miyakoshi Y. Enhancement of lipid peroxidation in the liver of mice exposed to magnetic fields. Ind. Health. 1997; 35:285–290.
- 19. Yokus B, Cakir DU, Akdag MZ. et al. Oxidative DNA damage in rats exposed to extremely low frequency electro magnetic fields. Free Radic. Res. 2005; 39:317–323.
- 20. Bediz CS, Baltaci AK, Mogulkoc R, et al. Zinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brain. Tohoku J. Exp. Med. 2006; 208:133–140.
- 21. Guler G, Seyhan N, Aricioglu A. Effects of static and 50 Hz alternating electric fields on superoxide dismutase activity and TBARS levels in guinea pigs. Gen. Physiol. Biophys. 2006. 25:177–193.
Toplam 19 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Medical Science Research Makaleler |
| Yazarlar | |
| Proje Numarası | yok |
| Yayımlanma Tarihi | 20 Mayıs 2020 |
| Kabul Tarihi | 11 Mayıs 2020 |
| Yayımlandığı Sayı | Yıl 2020Cilt: 42 Sayı: 1 |