Araştırma Makalesi
Bir üniversite hastanesinde COVID-19 hastaları; klinik özellikler ve eşlik eden hastalıklar, prospektif bir çalışma
Öz
Amaç: Bu çalışmanın amacı bir pandemi hastanesine başvuran ve COVID-19 tanı konulan hastaların demografik verilerini, laboratuvar test neticelerini ve redyolojik görüntüleme çalışmalarını incelemektir.
Yöntem: Tek merkezde, prospektif gözlemsel bu çalışmada Nisan ve Mayıs 2020 tarihleri arasında pandemi hastanesine başvuran ve COVID-19 tanısı konulan 57 hasta incelenmiştir. SARS-CoV-2 PCR testi negatif saptanan veya 18 yaş altında olan hastalar çalışma dışı tutulmuştur.
Bulgular: Hastaların ortalama yaşı 44,9 idi. En sık gözlenen yakınmalar sırasıyla kas ağrısı (%61 ), yüksek ateş (%58) ve öksürük (%54) olarak saptanmıştır. En sık saptanılan anormal laboratuvar değerleri CRP (%67) ve LDH (%40) yükselmesi ve lenfopeni (%27) olarak gözlenmiştir. Hastaların üçte birinde eşlik eden hastalık mevcuttu ve en sık saptanan eşlik eden hastalık hipertansiyon (%23) idi. Bilgisayarlı tomografide viral pnömoni saptanan hastaların %84'ünde bilateral tutulum vardı.
Sonuç: Yüksek ateş, öksürük ile miyalji yakınmaları olan ve laboratuvar değerlerinde LDH, CRP yüksekliği ile lenfopeni saptanan hastaların COVID-19 hastalığı açısından değerlendirilmesi gerekir.
Destekleyen Kurum
Yok
Proje Numarası
yok
Kaynakça
- 1. World Health Organization. Rolling updates on coronavirus disease (COVID-19). 2020 (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen).
- 2. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7.
- 3. Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, Huang H, Li C. Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features. Invest Radiol. 2020 May;55(5):257-261. doi: 10.1097/RLI.0000000000000670.
- 4. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. https://doi.org/10.1016/s0140-6736(20)30183-5.
- 5. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei C, Hui DSC, Du B, Li L, Zeng G, Yuen KY, Chen R, Tang C, Wang T, Chen P, Xiang J, Li S, Wang J, Liang Z, Peng Y, Wei L, Liu Y, Hu Y, Peng P, Wang J, Liu J, Chen Z, Li G, Zheng Z, Qiu S, Luo J, Ye C, Zhu S. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032.
- 6. Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. AJR Am J Roentgenol. 2020 Mar 3:1-6. doi: 10.2214/AJR.20.22976.
- 7. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y,Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet 2020, 395 (10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020. doi:10.1016/S0140-6736(20)30566-3.
- 8. Brogly N, Devos P, Boussekey N, Georges H, Chiche A, Leroy O. Impact of thrombocytopenia on outcome of patients admitted to ICU for severe community-acquired pneumonia. J Infect2007;55:136–140. doi:10.1016/j.jinf.2007.01.011.
- 9. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J, Coppa K, Diefenbach MA, Dominello AJ, Duer-Hefele J, Falzon L, Gitlin J, Hajizadeh N, Harvin TG, Hirschwerk DA, Kim EJ, Kozel ZM, Marrast LM, Mogavero JN, Osorio GA, Qiu M, Zanos TP. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA 2020, 323 (20), 2052. https://doi.org/10.1001/jama.2020.6775.
- 10. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA 2020, 323 (11), 1061. https://doi.org/10.1001/jama.2020.1585.
- 11. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Feb 24. doi: 10.1001/jama.2020.2648.
- 12. Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, Sepandi M, Jafari NJ, Izadi M, Qazvini A, Dorostkar R, Tat M, Shahriary A, Farnoosh G, Hosseini Zijoud SR, Taghdir M, Alimohamadi Y; Abbaszadeh S; Gouvarchin Ghaleh HE, Bagheri M. Epidemiological Characteristics of Coronavirus Disease 2019 (COVID-19) Patients in IRAN: A Single Center Study. Journal of Clinical Virology 2020, 127, 104378. https://doi.org/10.1016/j.jcv.2020.104378.
- 13. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020 Mar 23. doi: 10.1001/jama.2020.4683.
- 14. KCDC. Updates on COVID-19 in Korea. March 14, 2020. https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030 (Accessed on March 14, 2020)
- 15. Mizumoto K, Kagaya K4, Zarebski A, Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Euro Surveill. 2020 Mar;25(10). doi: 10.2807/1560-7917.ES.2020.25.10.2000180.
- 16. Gupta N, Praharaj I, Bhatnagar T, Vivian Thangaraj JW, Giri S, Chauhan H, Kulkarni S, Murhekar M, Singh S, Gangakhedkar RR, Bhargava B. Severe Acute Respiratory Illness Surveillance for Coronavirus Disease 2019, India, 2020. Indian J. Med. Res. 2020, 151 (2 & 3), 236–240. https://doi.org/10.4103/ijmr.IJMR_1035_20.
- 17. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, Rusconi S, Gervasoni C; Ridolfo AL, Rizzardini G, Antinori S, Galli M. Self-Reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-Sectional Study. Clinical Infectious Diseases 2020, ciaa330. https://doi.org/10.1093/cid/ciaa330.
- 18. Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, Satlin MJ, Campion TR, Nahid M, Ringel JB, Hoffman KL, Alshak MN, Li HA, Wehmeyer GT, Rajan M, Reshetnyak E, Hupert N, Horn EM, Martinez FJ, Gulick RM, Safford MM. Clinical Characteristics of Covid-19 in New York City. N Engl J Med 2020, 382 (24), 2372–2374. https://doi.org/10.1056/NEJMc2010419.
- 19. Wang Y, Wang Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. .J Med Virol. 2020 Mar 5. doi: 10.1002/jmv.25748.
- 20. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, Wang M. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020 Feb 21. doi: 10.1001/jama.2020.2565.
- 21. Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A.Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020 Mar 21;12(3):e7355. doi: 10.7759/cureus.7355.
COVID-19 patients in an university hospital; clinical characteristics and relationship with accompanying diseases, a prospective study
Öz
Objective: The aim of this study is to inspect demographic information, laboratory test results and radiologic imaging studies of patients admitting to a pandemic hospital who were diagnosed Covid-19.
Method: In this single center, prospective observational study, 57 patients who were diagnosed Covid-19 were inspected between April and May 2020. Patients under 18 of age, and patients whose SARS-CoV-2 PCR test were negative were excluded.
Results: Mean age of patients was 44.9. Myalgia (61%), high fever (58%), cough (54%) were most frequent complaints. Most frequent laboratory results were; increased CRP (67%) and LDH (40%) levels and lymphopenia (27%). One third of patients had accompanying diseases and most frequent accompanying disease was hypertension. Computed tomography imaging revealed bilateral involvement in 84% of patients having viral pneumonia.
Conclusions: Patients having complaints of high fever, cough, myalgia and laboratory findings of increased CRP and LDH levels and lymphopenia should be carefully evaluated for Covid-19.
Anahtar Kelimeler
Proje Numarası
yok
Kaynakça
- 1. World Health Organization. Rolling updates on coronavirus disease (COVID-19). 2020 (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen).
- 2. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7.
- 3. Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, Huang H, Li C. Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features. Invest Radiol. 2020 May;55(5):257-261. doi: 10.1097/RLI.0000000000000670.
- 4. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. https://doi.org/10.1016/s0140-6736(20)30183-5.
- 5. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei C, Hui DSC, Du B, Li L, Zeng G, Yuen KY, Chen R, Tang C, Wang T, Chen P, Xiang J, Li S, Wang J, Liang Z, Peng Y, Wei L, Liu Y, Hu Y, Peng P, Wang J, Liu J, Chen Z, Li G, Zheng Z, Qiu S, Luo J, Ye C, Zhu S. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032.
- 6. Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. AJR Am J Roentgenol. 2020 Mar 3:1-6. doi: 10.2214/AJR.20.22976.
- 7. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y,Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet 2020, 395 (10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020. doi:10.1016/S0140-6736(20)30566-3.
- 8. Brogly N, Devos P, Boussekey N, Georges H, Chiche A, Leroy O. Impact of thrombocytopenia on outcome of patients admitted to ICU for severe community-acquired pneumonia. J Infect2007;55:136–140. doi:10.1016/j.jinf.2007.01.011.
- 9. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J, Coppa K, Diefenbach MA, Dominello AJ, Duer-Hefele J, Falzon L, Gitlin J, Hajizadeh N, Harvin TG, Hirschwerk DA, Kim EJ, Kozel ZM, Marrast LM, Mogavero JN, Osorio GA, Qiu M, Zanos TP. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA 2020, 323 (20), 2052. https://doi.org/10.1001/jama.2020.6775.
- 10. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA 2020, 323 (11), 1061. https://doi.org/10.1001/jama.2020.1585.
- 11. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Feb 24. doi: 10.1001/jama.2020.2648.
- 12. Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, Sepandi M, Jafari NJ, Izadi M, Qazvini A, Dorostkar R, Tat M, Shahriary A, Farnoosh G, Hosseini Zijoud SR, Taghdir M, Alimohamadi Y; Abbaszadeh S; Gouvarchin Ghaleh HE, Bagheri M. Epidemiological Characteristics of Coronavirus Disease 2019 (COVID-19) Patients in IRAN: A Single Center Study. Journal of Clinical Virology 2020, 127, 104378. https://doi.org/10.1016/j.jcv.2020.104378.
- 13. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020 Mar 23. doi: 10.1001/jama.2020.4683.
- 14. KCDC. Updates on COVID-19 in Korea. March 14, 2020. https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030 (Accessed on March 14, 2020)
- 15. Mizumoto K, Kagaya K4, Zarebski A, Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Euro Surveill. 2020 Mar;25(10). doi: 10.2807/1560-7917.ES.2020.25.10.2000180.
- 16. Gupta N, Praharaj I, Bhatnagar T, Vivian Thangaraj JW, Giri S, Chauhan H, Kulkarni S, Murhekar M, Singh S, Gangakhedkar RR, Bhargava B. Severe Acute Respiratory Illness Surveillance for Coronavirus Disease 2019, India, 2020. Indian J. Med. Res. 2020, 151 (2 & 3), 236–240. https://doi.org/10.4103/ijmr.IJMR_1035_20.
- 17. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, Rusconi S, Gervasoni C; Ridolfo AL, Rizzardini G, Antinori S, Galli M. Self-Reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-Sectional Study. Clinical Infectious Diseases 2020, ciaa330. https://doi.org/10.1093/cid/ciaa330.
- 18. Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, Satlin MJ, Campion TR, Nahid M, Ringel JB, Hoffman KL, Alshak MN, Li HA, Wehmeyer GT, Rajan M, Reshetnyak E, Hupert N, Horn EM, Martinez FJ, Gulick RM, Safford MM. Clinical Characteristics of Covid-19 in New York City. N Engl J Med 2020, 382 (24), 2372–2374. https://doi.org/10.1056/NEJMc2010419.
- 19. Wang Y, Wang Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. .J Med Virol. 2020 Mar 5. doi: 10.1002/jmv.25748.
- 20. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, Wang M. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020 Feb 21. doi: 10.1001/jama.2020.2565.
- 21. Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A.Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020 Mar 21;12(3):e7355. doi: 10.7759/cureus.7355.
Toplam 21 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Dahili Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Proje Numarası | yok |
| Yayımlanma Tarihi | 21 Temmuz 2020 |
| Kabul Tarihi | 13 Temmuz 2020 |
| Yayımlandığı Sayı | Yıl 2020Cilt: 42 Sayı: 2 |