Öz
Objective: Primary hyperparathyroidism (PHPTH) is an endocrine disorder with hypercalcemia due to increased parathormone (PTH) release. This study aims to investigate the relationship between PHPTH and serum zinc and copper levels.
Method: 35 patients diagnosed with PHPT and 30 healthy control cases were included in the study. Serum zinc and copper levels were measured in all patients.
Results: There was no difference between the groups in terms of age and gender. It was detected that serum Zn levels were significantly lower and serum Cu levels were higher in the PHPTH group compared to the control group (PHPTH Zn: 85.8±24.9 μ/dL, Cu: 81.2±13.8 μ/dL and Control Zn: 103.3±21.3 μ/dL, Cu: 72.6±13.3 μ/dL p = 0.004, p= 0.013, respectively). There was a weak positive correlation between serum Cu levels and PTH levels.
Conclusions: Serum zinc and copper levels should be considered in the clarification of the pathogenesis of PHPTH and in treatment planning.