Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

Abdisa Tufa; Ayça Taş; Tuğba Ağbektaş; Ömer Topcu; Solomon Genet; Yavuz Siliğ

doi:10.7197/cmj.907003

EN

Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

Abstract

Objective: We aimed to analyzed the association between gastric cancer and polymorphism of XPO5 gene.

Method: The polymorphism in the XPO5 gene (rs11544382) was determined in 120 individuals (60 gastric cancer patients; 60 healthy controls) using Real-Time PCR method.

Results: The comparison of gastric cancer patients and controls revealed a statistically significant relationship for alcoholic drink consumption (p<0.05).The relationship between XPO5 gene (rs11544382) polymorphism and gastric cancer was statistically not significant. There was no a statistically significant relationship between mutant (GG) genotype with both wild type (AA) and heterozygous (AG) polymorphic genotypes when evaluated in XPO5 polymorphism gastric cancer patients and control groups (χ2:0.12, p=0.729). The heterozygous (AG) was dominant in gastric cancers patients and control subjects, 93.3 and 91.7% respectively.

Conclusions: This study provides information about allele

and genotype frequency distribution of XPO5 gene polymorphism (rs11544382) in Turkish At the same time, AG genotype was found to be dominant in gastric cancer patients and their controls.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Abdisa Tufa
0000-0003-2196-6835
Ethiopia

Ayça Taş ^*
0000-0002-7132-1325
Türkiye

Tuğba Ağbektaş
0000-0003-3433-8870
Türkiye

Ömer Topcu
0000-0002-1017-9820
Türkiye

Solomon Genet
0000-0002-5433-0107
Ethiopia

Yavuz Siliğ
0000-0002-0562-7457
Türkiye

Yayımlanma Tarihi

30 Eylül 2021

Gönderilme Tarihi

21 Mayıs 2021

Kabul Tarihi

26 Eylül 2021

Yayımlandığı Sayı

Yıl 1970 Cilt: 43 Sayı: 3

DOI

https://doi.org/10.7197/cmj.907003

IZ

https://izlik.org/JA98ZL67PW

Kaynak Göster

RIS / Bibtex

AMA

1.Tufa A, Taş A, Ağbektaş T, Topcu Ö, Genet S, Siliğ Y. Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer. CMJ. 2021;43(3):254-262. doi:10.7197/cmj.907003

Öz

Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster