Araştırma Makalesi
The relationship between preoperative - postoperative serum albumin levels and endometrial cancer prognostic factors
Öz
Objective: Hypoalbuminemia is an accepted prognostic indicator of increased morbidity and mortality; however, low serum albumin levels during the pre-treatment period are associated with poor survival in cancer patients. This study aimed to investigate the effects of pre- and post-operative albumin levels on endometrial cancer (EC) prognosis and patient survival.
Method: Clinical and laboratory data for 128 patients with EC were obtained retrospectively from the hospital archive. Pre- and post-operative serum albumin levels were compared with patients’ pathology results and survival.
Results: The mean age of the patients was 59.1 years, and 80.5% of patients had endometrioid type, 59.1% had grade 1 and 71.1% had stage I EC. The mean pre-operative albumin value of patients was 4.1 g/dL, and the mean post-operative albumin value of patients on post-operative day 1 was 3.39 g/dL. Both preoperative and postoperative albumin levels were found to be low in patients with have non-endometrioid type histology and advanced stage, which are considered as a poor prognostic factor in EC. While no correlation was found between the preoperative albumin level and overall survival, patients with a low postoperative albumin value showed poor survival.
Conclusions: The fact that serum albumin levels are associated with endometrial cancer prognostic factors suggests that albumin level may also be an independent prognostic factor, however prospective randomized studies are needed to make definite judgments on this issue.
Anahtar Kelimeler
Kaynakça
- References 1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 ;68(6):394-424
- 2. Kosary, CL. FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973‐87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. In Seminars in surgical oncology. New York: John Wiley & Sons, Inc; 1994:31-46.
- 3. Schink JC, Miller DS, Lurain JR, Rademaker AW. Tumor size in endometrial cancer. Cancer. 1991 1;67(11):2791-4cncr2820671113>3.0.co;2-s
- 4. Laky B, Janda M, Bauer J, Vavra C, Cleghorn G, Obermair A. Malnutrition among gynaecological cancer patients Eur J Clin Nutr. 2007;61(5):642-6.
- 5. Margarson MP, Soni N. Serum albumin: touchstone or totem? Anaesthesia. 1998;53(8):789-803.
- 6. Nicholson JP, Wolmarans MR, Park GR. The role of albumin in critical illness. Br J Anaesth. 2000;85(4):599-610.
- 7. Al-Shaiba R, McMillan DC, Angerson WJ, Leen E, McArdle CS, Horgan P. The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases. Br J Cancer. 2004 19;91(2):205-7
- 8. Al Murri AM, Bartlett JM, Canney PA, Doughty JC, Wilson C, McMillan DC. Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer. Br J Cancer. 2006 30;94(2):227-30.
- 9. Lien YC, Hsieh CC, Wu YC, Hsu HS, Hsu WH, Wang LS, et al. Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia. J Gastrointest Surg. 2004 ;8(8):1041-8
- 10. Fiala O, Pesek M, Finek J, Racek J, Minarik M, Benesova L, et al. Serum albumin is a strong predictor of survival in patients with advanced-stage non-small cell lung cancer treated with erlotinib. Neoplasma. 2016;63(3):471-6.
- 11. Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I. Endometrial cancer. Lancet 2005 ;366:491-505.
- 12. Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature. Nutr J. 2010 22;9:69.
- 13. Di Fiore F, Lecleire S, Pop D, Rigal O, Hamidou H, Paillot B, et al. Baseline nutritional status is predictive of response to treatment and survival in patients treated by definitive chemoradiotherapy for a locally advanced esophageal cancer. Am J Gastroenterol. 2007;102(11):2557-63.
- 14. Ishizuka M, Nagata H, Takagi K, Horie T, Kubota K. Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer. Ann Surg. 2007;246(6):1047-51
- 15. Yeun JY, Kaysen GA. Factors influencing serum albumin in dialysis patients. Am J Kidney Dis. 1998 ;32(6 Suppl 4):S118-25.
- 16. Ayhan A, Günakan E, Alyazıcı İ, Haberal N, Altundağ Ö, Dursun P. The preoperative albumin level is an independent prognostic factor for optimally debulked epithelial ovarian cancer. Arch Gynecol Obstet. 2017 ;296(5):989-995.
- 17. Asher V, Lee J, Bali A. Preoperative serum albumin is an independent prognostic predictor of survival in ovarian cancer. Med Oncol. 2012;29(3):2005-9.
- 18. Seebacher V, Grimm C, Reinthaller A, Heinze G, Tempfer C, Hefler L, et al. The value of serum albumin as a novel independent marker for prognosis in patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol. 2013;171(1):101-6.
- 19. Lei J, Wang Y, Guo X, Yan S, Ma D, Wang P, et al. Low preoperative serum ALB level is independently associated with poor overall survival in endometrial cancer patients. Future Oncol. 2020;16(8):307-316.
Yıl 2021,
Cilt: 43 Sayı: 4, 420 - 426, 31.12.2021
Öz
Kaynakça
- References 1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 ;68(6):394-424
- 2. Kosary, CL. FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973‐87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. In Seminars in surgical oncology. New York: John Wiley & Sons, Inc; 1994:31-46.
- 3. Schink JC, Miller DS, Lurain JR, Rademaker AW. Tumor size in endometrial cancer. Cancer. 1991 1;67(11):2791-4cncr2820671113>3.0.co;2-s
- 4. Laky B, Janda M, Bauer J, Vavra C, Cleghorn G, Obermair A. Malnutrition among gynaecological cancer patients Eur J Clin Nutr. 2007;61(5):642-6.
- 5. Margarson MP, Soni N. Serum albumin: touchstone or totem? Anaesthesia. 1998;53(8):789-803.
- 6. Nicholson JP, Wolmarans MR, Park GR. The role of albumin in critical illness. Br J Anaesth. 2000;85(4):599-610.
- 7. Al-Shaiba R, McMillan DC, Angerson WJ, Leen E, McArdle CS, Horgan P. The relationship between hypoalbuminaemia, tumour volume and the systemic inflammatory response in patients with colorectal liver metastases. Br J Cancer. 2004 19;91(2):205-7
- 8. Al Murri AM, Bartlett JM, Canney PA, Doughty JC, Wilson C, McMillan DC. Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer. Br J Cancer. 2006 30;94(2):227-30.
- 9. Lien YC, Hsieh CC, Wu YC, Hsu HS, Hsu WH, Wang LS, et al. Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia. J Gastrointest Surg. 2004 ;8(8):1041-8
- 10. Fiala O, Pesek M, Finek J, Racek J, Minarik M, Benesova L, et al. Serum albumin is a strong predictor of survival in patients with advanced-stage non-small cell lung cancer treated with erlotinib. Neoplasma. 2016;63(3):471-6.
- 11. Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I. Endometrial cancer. Lancet 2005 ;366:491-505.
- 12. Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature. Nutr J. 2010 22;9:69.
- 13. Di Fiore F, Lecleire S, Pop D, Rigal O, Hamidou H, Paillot B, et al. Baseline nutritional status is predictive of response to treatment and survival in patients treated by definitive chemoradiotherapy for a locally advanced esophageal cancer. Am J Gastroenterol. 2007;102(11):2557-63.
- 14. Ishizuka M, Nagata H, Takagi K, Horie T, Kubota K. Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer. Ann Surg. 2007;246(6):1047-51
- 15. Yeun JY, Kaysen GA. Factors influencing serum albumin in dialysis patients. Am J Kidney Dis. 1998 ;32(6 Suppl 4):S118-25.
- 16. Ayhan A, Günakan E, Alyazıcı İ, Haberal N, Altundağ Ö, Dursun P. The preoperative albumin level is an independent prognostic factor for optimally debulked epithelial ovarian cancer. Arch Gynecol Obstet. 2017 ;296(5):989-995.
- 17. Asher V, Lee J, Bali A. Preoperative serum albumin is an independent prognostic predictor of survival in ovarian cancer. Med Oncol. 2012;29(3):2005-9.
- 18. Seebacher V, Grimm C, Reinthaller A, Heinze G, Tempfer C, Hefler L, et al. The value of serum albumin as a novel independent marker for prognosis in patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol. 2013;171(1):101-6.
- 19. Lei J, Wang Y, Guo X, Yan S, Ma D, Wang P, et al. Low preoperative serum ALB level is independently associated with poor overall survival in endometrial cancer patients. Future Oncol. 2020;16(8):307-316.
Toplam 19 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Surgical Science Research Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2021 |
| Kabul Tarihi | 27 Aralık 2021 |
| Yayımlandığı Sayı | Yıl 2021Cilt: 43 Sayı: 4 |