Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril

Rukiye Aslan; Ayşe Hümeyra Taşkın Kafa

doi:10.7197/cmj.1064847

EN

Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril

Abstract

Objective: Captopril is a long-acting human angiotensin-converting enzyme (ACE) inhibitor that has been used to treat hypertension and heart failure for many years. In this study, it was aimed to determine the antimicrobial activity of L-captopril on Methicillin-Resistant Staphylococcus aureus MRSA and Methicillin-Sensitive Staphylococcus aureus (MSSA) clinical isolates and, demonstrate the combination activity of captopril with ciprofloxacin (CXP) and gentamicin (GEN), which are among antistaphylococcal chemical agents.
Method: The minimum inhibitor concentration (MIC) and minimum bactericidal concentration (MBC) were determined using the microdilution technique in 96-well microtiter plates. The activity of L-captopril and CXP or GEN combination against MRSA and MSSA clinical isolates was determined by the micro-broth checkerboard assay method.
Results: The captopril MIC value was determined to be 2.5 mg/ml in all bacteria strains tested. The captopril/CXP combination had an indifferent effect in the other strains tested except for one MRSA isolate. The captopril/GEN combination had an antagonistic effect in all strains studied and increased the MIC 2-4 fold. The captopril/GEN combination was found to reduce the bactericidal activity of gentamicin.
Conclusions: The study results suggest that exposure to these drugs may lead to multidrug resistance in S. aureus bacteria. Especially in the hypertensive patient group, the induced resistance in any S. aureus infections should be taken into consideration while using captopril and, it should be considered that this antagonism may cause an increase in S. aureus infections.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Rukiye Aslan ^*
0000-0001-5843-626X
Türkiye

Ayşe Hümeyra Taşkın Kafa
0000-0002-7282-4928
Türkiye

Yayımlanma Tarihi

30 Mart 2022

Gönderilme Tarihi

29 Ocak 2022

Kabul Tarihi

8 Mart 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 44 Sayı: 1

DOI

https://doi.org/10.7197/cmj.1064847

IZ

https://izlik.org/JA67KF46RJ

Kaynak Göster

RIS / Bibtex

AMA

1.Aslan R, Taşkın Kafa AH. Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril. CMJ. 2022;44(1):17-21. doi:10.7197/cmj.1064847

Öz

Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster