Objective: Kidney transplantation is the best treatment option for patients with end-stage renal disease. However, renal transplant recipients have been shown to have a higher risk of cancer than the general population. This has been attributed to malignancies associated with immunosuppression in these patients. In our study, we aimed to investigate the incidence of post-transplant malignancy, duration of development and risk factors in kidney transplant recipients.
Method: 1029 patients who underwent kidney transplantation in our organ transplant clinic between January 2006 and December 2018 were analyzed retrospectively through their demographic data, immunosuppressive protocols, post-transplant cancer types, and cancer onset files.
Results: Cancer developed in a total of 21 recipients (2%). The donor of 89.5% of the cases was alive. There was a history of smoking in 64.3% of the cases, and a family history of cancer in 45.5%. The most common type of cancer was skin cancer (n: 4). Basal cell Ca in 2 cases with skin cancer, Kaposi sarcoma in 1 case, and Merkel Cell Ca in 1 case (Table 2). Two of our patients with lung cancer had a history of smoking. The family history of our 2 cases with gastric cancer was positive. However, no statistically significant difference was found between family history and smoking and cancer incidence (p=0.576)
Conclusions: As transplant recipients continue to live longer with improved outcomes, cancer will increase as a cause of morbidity and mortality in this population. More research is needed to understand whether tumors arising in this population are affected by the patient's immunosuppression.
|Konular||Sağlık Bilimleri ve Hizmetleri|
|Bölüm||Dahili Tıp Bilimleri Araştırma Yazıları|
|Yayımlanma Tarihi||30 Mart 2022|
|Yayınlandığı Sayı||Yıl 2022, Cilt 44, Sayı 1|