Araştırma Makalesi
BibTex RIS Kaynak Göster

Yıl 2022, Cilt: 44 Sayı: 4, 327 - 337, 31.12.2022

Mateen Sadeq Aysel Sarı

https://doi.org/10.7197/cmj.1082096

Öz

Kaynakça

  • [1] care, A.D.A.J.D., 2004. Diagnosis and claSDification of diabetes mellitus, 27, S5.
  • [2] care, A.D.A.J.D., 2013. Diagnosis and claSDification of diabetes mellitus, 36(Supplement 1), S67-S74.
  • [3] Wilcox, G.J.C.b.r., 2005. Insulin and insulin resistance, 26(2), 19.
  • [4] Tan, Y., Chang, S.K., Zhang, Y.F. 2017. Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera, 214, 259-268.
  • [5] RoSDi, E.J., Sim, L., Kuntz, D.A., Hahn, D., Johnston, B.D., Ghavami, A., Szczepina, M.G., Kumar, N.S., Sterchi, E.E., and Nichols, B.L.J.T.F.j., 2006. Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives, 273(12), 2673-2683.
  • [6] Jin Chan, S. Steiner, D.F.J.A.Z., 2000. Insulin through the ages: phylogeny of a growth promoting and metabolic regulatory hormone, 40(2), 213-222.
  • [7] Petersen, M.C. Shulman, G.I.J.P.r., 2018. Mechanisms of insulin action and insulin resistance, 98(4), 2133-2223.
  • [8] Kahn, B.B. Flier, J.S.J.T.J.o.c.i., 2000. Obesity and insulin resistance, 106(4), 473-481.
  • [9] Zimmet, P., Alberti, K., Shaw, J., 2001. Global and societal implications of the diabetes epidemic, Nature, 414(6865), 782.
  • [10] Wild, S., Roglic, G., Green, A., Sicree, R., King, H., 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, Diabetes care, 27(5), 1047-1053.
  • [11] BliSD, M.J.D.C., 1993. The history of insulin, 16(Supplement 3), 4-7.
  • [12] Alberti, K.G.M.M., Zimmet, P., and DeFronzo, R.A., 1997. International textbook of DM, J. Wiley.
  • [13] Cefalu, W.T.J.E., and medicine, 2001. Insulin resistance: cellular and clinical concepts, 226(1), 13-26.
  • [14] Minokoshi, Y., Kim, Y.-B., Peroni, O.D., Fryer, L.G., Müller, C., Carling, D., Kahn, B.B.J.N., 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, 415(6869), 339.
  • [15] Park, H.-K. Ahima, R.S., 2015. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism, Metabolism, 64(1), 24-34.
  • [16] Grinspoon, S., Gulick, T., Askari, H., Landt, M., Lee, K., Anderson, E., Ma, Z., Vignati, L., Bowsher, R., Herzog, D.J.T.J.o.C.E.,1996. Serum leptin levels in women with anorexia nervosa, Metabolism 81(11), 3861-3863.
  • [17] Ahima, R.S. Flier, J.S.J.A.r.o.p., 2000. Leptin, 62(1), 413-437.
  • [18] Nicholson, T., Church, C., Baker, D.J., Jones, S.W., 2018. The role of adipokines in skeletal muscle inflammation and insulin sensitivity, Journal of Inflammation, 15(1), 9.
  • [19] Tyson, P., Cooper, G.R.J., McCarthy, T.J.I.J.o.C.A.J.o.t.R.M.S., 2002. Millennial to multi‐decadal variability in the climate of southern Africa, 22(9), 1105-1117.
  • [20] Di Marzo V., Goparaju S.K., Wang L., Liu, J., Bátkai S., Járai Z., Fezza F., Miura G.I., Palmiter R.D., Sugiura T.J.N., 2001. Leptin-regulated endocannabinoids are involved in maintaining food intake, 410(6830), 822.
  • [21] Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdán, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J.J.N., 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus, 411(6836), 480.
  • [22] Spiegel, K., Tasali, E., Penev, P., Van Cauter, E.J.A.o.i.m., 2004. Brief communication: sleep curtailment in healthy young men is aSDociated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite, 141(11), 846-850.
  • [23] Taheri, S., Lin, L., Austin, D., Young, T., Mignot, E.J.P.m., 2004. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body maSD index, 1(3), e62.
  • [24] Wauman, J., Zabeau, L.,Tavernier, J., 2017. The leptin receptor complex: heavier than expected?, Frontiers in endocrinology, 8, 30.
  • [25] D'souza, A.M., Neumann, U.H., Glavas, M.M., Kieffer, T.J., 2017. The glucoregulatory actions of leptin, Molecular metabolism, 6(9), 1052-1065.
  • [26] Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M., 1994. Positional cloning of the mouse obese gene and its human homologue, Nature, 372(6505), 425.
  • [27] Ceddia, R.B., Koistinen, H.A., Zierath, J.R., Sweeney, G., 2002. Analysis of paradoxical observations on the aSDociation between leptin and insulin resistance, The FASEB journal, 16(10), 1163-1176.
  • [28] Havel, P.J., Kasim-Karakas, S., Mueller, W., Johnson, P.R., Gingerich, R.L., Stern, J.S., 1996. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loSD, The Journal of Clinical Endocrinology & Metabolism, 81(12), 4406-4413.
  • [29] Unger R.H. Roth M.G., 2015. A new biology of diabetes revealed by leptin, Cell metabolism, 21(1), 15-20.
  • [30] Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., 1997. Nonadipose tiSDue production of leptin: leptin as a novel placenta-derived hormone in humans, Nature medicine, 3(9), 1029.
  • [31] Scolaro, L., CaSDone, M., Kolaczynski, J.W., Otvos Jr, L., Surmacz, E., 2010. Leptin-based therapeutics, Expert review of endocrinology & metabolism, 5(6), 875-889.
  • [32] Mcneely, M.J., Boyko, E.J., Weigle, D.S., Shofer, J.B., CheSDler, S.D., Leonnetti, D.L., Fujimoto, W.Y., 1999. ASDociation between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans, Diabetes care, 22(1), 65-70.
  • [33] Dagogo-Jack S., Fanelli C., Paramore D., Brothers J., Landt, M.J.D., 1996. Plasma leptin and insulin relationships in obese and nonobese humans, 45(5), 695-698.
  • [34] Wang J., Obici S., Morgan K., Barzilai N., Feng Z., RoSDetti, L.J.D., 2001. Overfeeding rapidly induces leptin and insulin resistance, 50(12), 2786-2791.
  • [35] Harris, R.B.J.B. and communications, b.r., 1998. Acute and chronic effects of leptin on glucose utilization in lean mice, 245(2), 502-509.
  • [36] Barzilai, N., She, L., Liu, L., Wang, J., Hu, M., Vuguin, P., RoSDetti, L.J.A.J.o.P.-E., Metabolism, 1999. Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action, 277(2), E291-E298.
  • [37] Wauters, M., Considine, R.V., Van Gaal, L.F.J.E.j.o.e., 2000. Human leptin: from an adipocyte hormone to an endocrine mediator, 143(3), 293-311.
  • [38] Chan, M.J.W.H.O., Geneva, Switzerland, 2016. Global report on diabetes, 1-88.
  • [39] Olokoba A.B., Obateru O.A., Olokoba, L.B.J.O.m.j., 2012. T’DM: a review of current trends, 27(4), 269.
  • [40] ASDociation, A.D.A.J.C.d.a.p.o.t.A.D., 2015. Standards of medical care in diabetes—2015 abridged for primary care providers, 33(2), 97.
  • [41] Zheng, Y., Ley, S.H., Hu, F.B.J.N.R.E., 2018. Global aetiology and epidemiology of Type 2 diabetes mellitus and its complications, 14(2), 88.
  • [42] Benoit, S.C., Clegg, D.J., Seeley, R.J., Woods, S.C.J.R.p.i.h.r., 2004. Insulin and leptin as adiposity signals, 59, 267-286.
  • [43] Al-Zubaidi, R. Abbas, M.J.k.j.o.p.s., 2017. Association Between Total antioxidant Capacity and Leptin Levels in Type-2 Diabetic Patients, (12), 29-33.
  • [44] Moonishaa, T.M., Nanda, S.K., Shamraj, M., Sivaa, R., Sivakumar, P., Ravichandran, K.J.I.J.o.A., and Research, B.M., 2017. Evaluation of leptin as a marker of insulin resistance in T2DM, 7(3), 176.
  • [45] Diwan, A.G., Kuvalekar, A.A., Dharamsi, S., Vora, A.M., Nikam, V.A., Ghadge, A.A.J.I.j.o.e., and metabolism, 2018. Correlation of serum adiponectin and leptin levels in obesity and type 2 diabetes mellitus, 22(1), 93.
  • [46] Taher, N.J.I.A.-H.J.F.P. and Science, A., 2017. The Effect of Leptin Hormone Levels In Type (II) Diabetic Nephropathy Patients, 22(3).
  • [47] Altawil, H.J.A.J.L.S. and some Biochemical Parameters among T2DM Females in the Gaza Governorate, G.S., 2009. Leptin status and some biochemical parameters among T2DM females in the Gaza Governorate, Gaza Strip.
  • [48] Czech, M.P.J.N.m., 2017. Insulin action and resistance in obesity and T2DM, 23(7), 804-814.
  • [49] Shebl, T.H., Noor El Deen, A.A.,Younis, H.A., Soliman, A.M., Ashmawy, A.M., Ali, M.M.N.J.J.o.C.M.R., Practice, 2017. Relationship between serum leptin concentration and insulin resistance syndrome in patients with T2DM, 2(2), 125.
  • [50] Bhupathiraju, S.N. Hu, F.B.J.C.r., 2016. Epidemiology of obesity and diabetes and their cardiovascular complications, 118(11), 1723-1735.
  • [51] Hosoi, T. Maffei, M.J.F.i.e., 2017. leptin resistance in Metabolic disorders: PoSDible Mechanisms and treatments, 8, 300.
  • [52] Antwi, J., Proulx, W., Sullivan, S., Lavin, R., and Bellavia, M.J.T.F.J., 2018. Serum Leptin is a Sociated with Fasting Plasma Glucose and Serum Insulin Levels independent of BMI in Haitian Americans with T2DM, 32(1_supplement), 670.9-670.9.
  • [53] Zhao, Q., Laukkanen, J.A., Li, Q., Li, G.J.C.i.i.a., 2017. Body maSD index is a Sociated with T2DM in Chinese elderly, 12, 745.
  • [54] Krag, M.Ø., HaSDelbalch, L., Siersma, V., Nielsen, A.B., Reventlow, S., Malterud, K., and de Fine Olivarius, N.J.D., 2016. The impact of gender on the long-term morbidity and mortality of patients with T2DM receiving structured personal care: a 13 year follow-up study, 59(2), 275-285.
  • [55] Alzamil, H.J.J.o.O., 2020. Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is ASDociated with Glycemic Control and Insulin Resistance, 2020

Study of Serum Leptin Level in Patients Diabetes Mellitus Type 2: in Relation with Insulin Level

Yıl 2022, Cilt: 44 Sayı: 4, 327 - 337, 31.12.2022

Mateen Sadeq Aysel Sarı

https://doi.org/10.7197/cmj.1082096

Öz

Leptin is a food intake hormone. Informed leptin diet provides adequate nutrition. Leptin plays an important role in T2DM. Having high leptin and being in love is not a reason for preference. Evaluation of serum and ptin levels in T2DM patients and healthy patients, and the relationship between serum fasting insulin and leptin in T2DM. In the endocrine and market cross-sectional education, a total of 92 serums were studied, including 70 patients with T2DM and 22 patients who were not healthy. Serum leptin was measured by ELISA, serum insulin autoanalyzer Cobas E411. Hemoglobin was studied with HPLC D10. Posting regarding serum leptin and insulin, fasting and BMI. In this study, a significant relationship was observed between leptin and insulin and T2DM, and a significant positive relationship between leptin and insulin (p<0.001, r=0.479) was observed.

Anahtar Kelimeler

Leptin Insulin Type 2 Diabetes Mellitus Serum

Kaynakça

  • [1] care, A.D.A.J.D., 2004. Diagnosis and claSDification of diabetes mellitus, 27, S5.
  • [2] care, A.D.A.J.D., 2013. Diagnosis and claSDification of diabetes mellitus, 36(Supplement 1), S67-S74.
  • [3] Wilcox, G.J.C.b.r., 2005. Insulin and insulin resistance, 26(2), 19.
  • [4] Tan, Y., Chang, S.K., Zhang, Y.F. 2017. Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera, 214, 259-268.
  • [5] RoSDi, E.J., Sim, L., Kuntz, D.A., Hahn, D., Johnston, B.D., Ghavami, A., Szczepina, M.G., Kumar, N.S., Sterchi, E.E., and Nichols, B.L.J.T.F.j., 2006. Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives, 273(12), 2673-2683.
  • [6] Jin Chan, S. Steiner, D.F.J.A.Z., 2000. Insulin through the ages: phylogeny of a growth promoting and metabolic regulatory hormone, 40(2), 213-222.
  • [7] Petersen, M.C. Shulman, G.I.J.P.r., 2018. Mechanisms of insulin action and insulin resistance, 98(4), 2133-2223.
  • [8] Kahn, B.B. Flier, J.S.J.T.J.o.c.i., 2000. Obesity and insulin resistance, 106(4), 473-481.
  • [9] Zimmet, P., Alberti, K., Shaw, J., 2001. Global and societal implications of the diabetes epidemic, Nature, 414(6865), 782.
  • [10] Wild, S., Roglic, G., Green, A., Sicree, R., King, H., 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, Diabetes care, 27(5), 1047-1053.
  • [11] BliSD, M.J.D.C., 1993. The history of insulin, 16(Supplement 3), 4-7.
  • [12] Alberti, K.G.M.M., Zimmet, P., and DeFronzo, R.A., 1997. International textbook of DM, J. Wiley.
  • [13] Cefalu, W.T.J.E., and medicine, 2001. Insulin resistance: cellular and clinical concepts, 226(1), 13-26.
  • [14] Minokoshi, Y., Kim, Y.-B., Peroni, O.D., Fryer, L.G., Müller, C., Carling, D., Kahn, B.B.J.N., 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, 415(6869), 339.
  • [15] Park, H.-K. Ahima, R.S., 2015. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism, Metabolism, 64(1), 24-34.
  • [16] Grinspoon, S., Gulick, T., Askari, H., Landt, M., Lee, K., Anderson, E., Ma, Z., Vignati, L., Bowsher, R., Herzog, D.J.T.J.o.C.E.,1996. Serum leptin levels in women with anorexia nervosa, Metabolism 81(11), 3861-3863.
  • [17] Ahima, R.S. Flier, J.S.J.A.r.o.p., 2000. Leptin, 62(1), 413-437.
  • [18] Nicholson, T., Church, C., Baker, D.J., Jones, S.W., 2018. The role of adipokines in skeletal muscle inflammation and insulin sensitivity, Journal of Inflammation, 15(1), 9.
  • [19] Tyson, P., Cooper, G.R.J., McCarthy, T.J.I.J.o.C.A.J.o.t.R.M.S., 2002. Millennial to multi‐decadal variability in the climate of southern Africa, 22(9), 1105-1117.
  • [20] Di Marzo V., Goparaju S.K., Wang L., Liu, J., Bátkai S., Járai Z., Fezza F., Miura G.I., Palmiter R.D., Sugiura T.J.N., 2001. Leptin-regulated endocannabinoids are involved in maintaining food intake, 410(6830), 822.
  • [21] Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdán, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J.J.N., 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus, 411(6836), 480.
  • [22] Spiegel, K., Tasali, E., Penev, P., Van Cauter, E.J.A.o.i.m., 2004. Brief communication: sleep curtailment in healthy young men is aSDociated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite, 141(11), 846-850.
  • [23] Taheri, S., Lin, L., Austin, D., Young, T., Mignot, E.J.P.m., 2004. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body maSD index, 1(3), e62.
  • [24] Wauman, J., Zabeau, L.,Tavernier, J., 2017. The leptin receptor complex: heavier than expected?, Frontiers in endocrinology, 8, 30.
  • [25] D'souza, A.M., Neumann, U.H., Glavas, M.M., Kieffer, T.J., 2017. The glucoregulatory actions of leptin, Molecular metabolism, 6(9), 1052-1065.
  • [26] Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M., 1994. Positional cloning of the mouse obese gene and its human homologue, Nature, 372(6505), 425.
  • [27] Ceddia, R.B., Koistinen, H.A., Zierath, J.R., Sweeney, G., 2002. Analysis of paradoxical observations on the aSDociation between leptin and insulin resistance, The FASEB journal, 16(10), 1163-1176.
  • [28] Havel, P.J., Kasim-Karakas, S., Mueller, W., Johnson, P.R., Gingerich, R.L., Stern, J.S., 1996. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loSD, The Journal of Clinical Endocrinology & Metabolism, 81(12), 4406-4413.
  • [29] Unger R.H. Roth M.G., 2015. A new biology of diabetes revealed by leptin, Cell metabolism, 21(1), 15-20.
  • [30] Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., 1997. Nonadipose tiSDue production of leptin: leptin as a novel placenta-derived hormone in humans, Nature medicine, 3(9), 1029.
  • [31] Scolaro, L., CaSDone, M., Kolaczynski, J.W., Otvos Jr, L., Surmacz, E., 2010. Leptin-based therapeutics, Expert review of endocrinology & metabolism, 5(6), 875-889.
  • [32] Mcneely, M.J., Boyko, E.J., Weigle, D.S., Shofer, J.B., CheSDler, S.D., Leonnetti, D.L., Fujimoto, W.Y., 1999. ASDociation between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans, Diabetes care, 22(1), 65-70.
  • [33] Dagogo-Jack S., Fanelli C., Paramore D., Brothers J., Landt, M.J.D., 1996. Plasma leptin and insulin relationships in obese and nonobese humans, 45(5), 695-698.
  • [34] Wang J., Obici S., Morgan K., Barzilai N., Feng Z., RoSDetti, L.J.D., 2001. Overfeeding rapidly induces leptin and insulin resistance, 50(12), 2786-2791.
  • [35] Harris, R.B.J.B. and communications, b.r., 1998. Acute and chronic effects of leptin on glucose utilization in lean mice, 245(2), 502-509.
  • [36] Barzilai, N., She, L., Liu, L., Wang, J., Hu, M., Vuguin, P., RoSDetti, L.J.A.J.o.P.-E., Metabolism, 1999. Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action, 277(2), E291-E298.
  • [37] Wauters, M., Considine, R.V., Van Gaal, L.F.J.E.j.o.e., 2000. Human leptin: from an adipocyte hormone to an endocrine mediator, 143(3), 293-311.
  • [38] Chan, M.J.W.H.O., Geneva, Switzerland, 2016. Global report on diabetes, 1-88.
  • [39] Olokoba A.B., Obateru O.A., Olokoba, L.B.J.O.m.j., 2012. T’DM: a review of current trends, 27(4), 269.
  • [40] ASDociation, A.D.A.J.C.d.a.p.o.t.A.D., 2015. Standards of medical care in diabetes—2015 abridged for primary care providers, 33(2), 97.
  • [41] Zheng, Y., Ley, S.H., Hu, F.B.J.N.R.E., 2018. Global aetiology and epidemiology of Type 2 diabetes mellitus and its complications, 14(2), 88.
  • [42] Benoit, S.C., Clegg, D.J., Seeley, R.J., Woods, S.C.J.R.p.i.h.r., 2004. Insulin and leptin as adiposity signals, 59, 267-286.
  • [43] Al-Zubaidi, R. Abbas, M.J.k.j.o.p.s., 2017. Association Between Total antioxidant Capacity and Leptin Levels in Type-2 Diabetic Patients, (12), 29-33.
  • [44] Moonishaa, T.M., Nanda, S.K., Shamraj, M., Sivaa, R., Sivakumar, P., Ravichandran, K.J.I.J.o.A., and Research, B.M., 2017. Evaluation of leptin as a marker of insulin resistance in T2DM, 7(3), 176.
  • [45] Diwan, A.G., Kuvalekar, A.A., Dharamsi, S., Vora, A.M., Nikam, V.A., Ghadge, A.A.J.I.j.o.e., and metabolism, 2018. Correlation of serum adiponectin and leptin levels in obesity and type 2 diabetes mellitus, 22(1), 93.
  • [46] Taher, N.J.I.A.-H.J.F.P. and Science, A., 2017. The Effect of Leptin Hormone Levels In Type (II) Diabetic Nephropathy Patients, 22(3).
  • [47] Altawil, H.J.A.J.L.S. and some Biochemical Parameters among T2DM Females in the Gaza Governorate, G.S., 2009. Leptin status and some biochemical parameters among T2DM females in the Gaza Governorate, Gaza Strip.
  • [48] Czech, M.P.J.N.m., 2017. Insulin action and resistance in obesity and T2DM, 23(7), 804-814.
  • [49] Shebl, T.H., Noor El Deen, A.A.,Younis, H.A., Soliman, A.M., Ashmawy, A.M., Ali, M.M.N.J.J.o.C.M.R., Practice, 2017. Relationship between serum leptin concentration and insulin resistance syndrome in patients with T2DM, 2(2), 125.
  • [50] Bhupathiraju, S.N. Hu, F.B.J.C.r., 2016. Epidemiology of obesity and diabetes and their cardiovascular complications, 118(11), 1723-1735.
  • [51] Hosoi, T. Maffei, M.J.F.i.e., 2017. leptin resistance in Metabolic disorders: PoSDible Mechanisms and treatments, 8, 300.
  • [52] Antwi, J., Proulx, W., Sullivan, S., Lavin, R., and Bellavia, M.J.T.F.J., 2018. Serum Leptin is a Sociated with Fasting Plasma Glucose and Serum Insulin Levels independent of BMI in Haitian Americans with T2DM, 32(1_supplement), 670.9-670.9.
  • [53] Zhao, Q., Laukkanen, J.A., Li, Q., Li, G.J.C.i.i.a., 2017. Body maSD index is a Sociated with T2DM in Chinese elderly, 12, 745.
  • [54] Krag, M.Ø., HaSDelbalch, L., Siersma, V., Nielsen, A.B., Reventlow, S., Malterud, K., and de Fine Olivarius, N.J.D., 2016. The impact of gender on the long-term morbidity and mortality of patients with T2DM receiving structured personal care: a 13 year follow-up study, 59(2), 275-285.
  • [55] Alzamil, H.J.J.o.O., 2020. Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is ASDociated with Glycemic Control and Insulin Resistance, 2020
Toplam 55 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Temel Tıp Bilimleri Araştırma Yazıları
Yazarlar

Mateen Sadeq 0000-0002-7902-1511

Aysel Sarı 0000-0002-4966-2254

Yayımlanma Tarihi 31 Aralık 2022
Kabul Tarihi 19 Aralık 2022
Yayımlandığı Sayı Yıl 2022Cilt: 44 Sayı: 4

Kaynak Göster

AMA Sadeq M, Sarı A. Study of Serum Leptin Level in Patients Diabetes Mellitus Type 2: in Relation with Insulin Level. CMJ. Aralık 2022;44(4):327-337. doi:10.7197/cmj.1082096