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Yıl 2022, Cilt: 44 Sayı: 4, 370 - 376, 31.12.2022

Mercan Taştemur Güneş Arık Hilal Heybeli Hande Selvi Öztorun Kamile Silay İhsan Ateş Denizcan Hastürk Büşra Betül Çağır Rana Tuna Doğrul Atacan Aras Erhan Özenç

https://doi.org/10.7197/cmj.1168081

Öz

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

yok

Kaynakça

  • Referans1. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, Ma K. A systematic review of asymptomatic infections with COVID-19. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2021;54(1):12-16.
  • Referans2. Coronavırus Resource Center. 2022; https://coronavirus.jhu.edu/live.
  • Referans3. Nanda A, Vura N, Gravenstein S. COVID-19 in older adults. Aging clinical and experimental research. 2020;32(7):1199-1202.
  • Referans4. Bansod S, Ahirwar AK, Sakarde A, Asia P, Gopal N, Alam S, Kaim K, Ahirwar P, Sorte SR.COVID-19 and geriatric population: from pathophysiology to clinical perspectives. Hormone molecular biology and clinical investigation. 2021;42(1):87-98.
  • Referans5. Lanser L, Burkert FR, Bellmann-Weiler R, Schroll A, Wildner S, Fritsche G, Weiss G. Dynamics in Anemia Development and Dysregulation of Iron Homeostasis in Hospitalized Patients with COVID-19. Metabolites. 2021;11(10).
  • Referans6. Cavezzi A, Troiani E, Corrao S. COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. Clinics and practice. 2020;10(2):1271.
  • Referans7. Chen C, Zhou W, Fan W, Ning X, Yang S, Lei Z, Zheng C.Association of anemia and COVID-19 in hospitalized patients. Future virology. 2021.
  • Referans8. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England). 2020;395(10229):1054-1062.
  • Referans9. Amano S, Ohta R, Sano C. Recognition of Anemia in Elderly People in a Rural Community Hospital. International journal of environmental research and public health. 2021;18(21).
  • Referans10. Melku M, Asefa W, Mohamednur A, et al. Magnitude of Anemia in Geriatric Population Visiting Outpatient Department at the University of Gondar Referral Hospital, Northwest Ethiopia: Implication for Community-Based Screening. Current gerontology and geriatrics research. 2018;2018:9869343.
  • Referans11. Gaskell H, Derry S, Andrew Moore R, McQuay HJ. Prevalence of anaemia in older persons: systematic review. BMC Geriatr. 2008 Jan 14;8:1. doi: 10.1186/1471-2318-8-1. PMID: 18194534; PMCID: PMC2248585.
  • Referans12. Artz AS, Thirman MJ. Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):925-32. doi: 10.1093/gerona/glr090. Epub 2011 Jun 9. PMID: 21659341.).
  • Referans13. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-2268. Referans14. Busti F, Campostrini N, Martinelli N, Girelli D. Iron deficiency in the elderly population, revisited in the hepcidin era. Frontiers in pharmacology. 2014;5:83.
  • Referans15. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nature immunology. 2006;7(4):333-337.
  • Referans16. Price EA, Mehra R, Holmes TH, Schrier SL. Anemia in older persons: etiology and evaluation. Blood cells, molecules & diseases. 2011;46(2):159-165.
  • Referans17. Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S, Hemmelgarn BR. Impact of anemia on hospitalization and mortality in older adults. Blood. 2006;107(10):3841-3846.
  • Referans18. Ohta R, Ryu Y, Kitayuguchi J, Gomi T, Katsube T. Challenges and solutions in the continuity of home care for rural older people: A thematic analysis. Home health care services quarterly. 2020;39(2):126-139.
  • Referans19. Benoit JL, Benoit SW, de Oliveira MHS, Lippi G, Henry BM. Anemia and COVID-19: A prospective perspective. Journal of medical virology. 2021;93(2):708-711.
  • Referans20. Tettamanti M, Lucca U, Gandini F, et al. Prevalence, incidence and types of mild anemia in the elderly: the "Health and Anemia" population-based study. Haematologica. 2010;95(11):1849-1856.
  • Referans21. Hemauer SJ, Kingeter AJ, Han X, Shotwell MS, Pandharipande PP, Weavind LM. Daily Lowest Hemoglobin and Risk of Organ Dysfunctions in Critically Ill Patients. Critical care medicine. 2017;45(5):e479-e484.
  • Referans22. Tao Z, Xu J, Chen W, Yang Z, Xu X, Liu L, Chen R, Xie J, Liu M, Wu J, Wang H, Liu J. Anemia is associated with severe illness in COVID-19: A retrospective cohort study. Journal of medical virology. 2021;93(3):1478-1488.
  • Referans23. Hariyanto TI, Kurniawan A. Anemia is associated with severe coronavirus disease 2019 (COVID-19) infection. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2020;59(6):102926-102926.
  • Referans24. Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, Wang G, Fu W, Xiao J, Ding X, Li T, Xiao X, Li C.Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Annals of translational medicine. 2020;8(9):593.
  • Referans25. Foy BH, Carlson JCT, Reinertsen E, Padros I Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM. Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection. JAMA network open. 2020;3(9):e2022058.

The Relationship Between Anemia and Mortality in Elderly COVID 19 Patients

Yıl 2022, Cilt: 44 Sayı: 4, 370 - 376, 31.12.2022

Mercan Taştemur Güneş Arık Hilal Heybeli Hande Selvi Öztorun Kamile Silay İhsan Ateş Denizcan Hastürk Büşra Betül Çağır Rana Tuna Doğrul Atacan Aras Erhan Özenç

https://doi.org/10.7197/cmj.1168081

Öz

Background: COVID 19 continues to affect the whole world with its different presentations and unenlightened aspects.Older patients are the group most at risk. Low hemoglobin levels contribute to hypoxia during COVID 19 infection and increase the risk of complications, especially in risky groups. In this study, we aimed to investigate the prevalence of anemia and its effect on mortality in geriatric COVID 19 patients.
Materials and Methods: Data of 251 patients over the age of 65 who were followed up in the Internal Medicine services allocated for COVID 19 of our hospital between August and October 2020, were included in the study. Anemia was defined as a hemoglobin level of 13 mg/dl in men and below 12 mg/dl in women at the time of admission. Demographic and laboratory data of the patients and hemoglobin levels were compared.
Results: The mean age of 251 COVID-19 patients included in the study was 75.6±7.6 years. 45.8% (n:115) of the patients were female and 54.2% (n:136). While 51.8% of the patients had anemia, the presence of anemia was found to be 67.9% in patients who died due to COVID 19. According to multivariate logistic regression analysis, advanced age (OR=1.082; 95% CI=1.03-1.137; p=0.002), presence of anemia (OR=1.969; 95% CI=1.113-4.246; p=0.034),hypertension (OR =5.763; 95% CI=1.713-19.389; p=0.005), dementia (OR=3.614; 95% CI=1.128-11.578; p=0.031) were determined as independent risk factors predicting mortality in patients with COVID-19.
Conclusion: Advance age, presence of anemia, hypertension and dementia has been found as İndependant risk factors for mortality in COVID 19 infection in our study. In elderly Covid 19 patients hemoglobin levels at admission may be helpful in predicting mortality.

Anahtar Kelimeler

COVID 19 Geriatric population Anemia Mortality

Proje Numarası

yok

Kaynakça

  • Referans1. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, Ma K. A systematic review of asymptomatic infections with COVID-19. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2021;54(1):12-16.
  • Referans2. Coronavırus Resource Center. 2022; https://coronavirus.jhu.edu/live.
  • Referans3. Nanda A, Vura N, Gravenstein S. COVID-19 in older adults. Aging clinical and experimental research. 2020;32(7):1199-1202.
  • Referans4. Bansod S, Ahirwar AK, Sakarde A, Asia P, Gopal N, Alam S, Kaim K, Ahirwar P, Sorte SR.COVID-19 and geriatric population: from pathophysiology to clinical perspectives. Hormone molecular biology and clinical investigation. 2021;42(1):87-98.
  • Referans5. Lanser L, Burkert FR, Bellmann-Weiler R, Schroll A, Wildner S, Fritsche G, Weiss G. Dynamics in Anemia Development and Dysregulation of Iron Homeostasis in Hospitalized Patients with COVID-19. Metabolites. 2021;11(10).
  • Referans6. Cavezzi A, Troiani E, Corrao S. COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. Clinics and practice. 2020;10(2):1271.
  • Referans7. Chen C, Zhou W, Fan W, Ning X, Yang S, Lei Z, Zheng C.Association of anemia and COVID-19 in hospitalized patients. Future virology. 2021.
  • Referans8. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England). 2020;395(10229):1054-1062.
  • Referans9. Amano S, Ohta R, Sano C. Recognition of Anemia in Elderly People in a Rural Community Hospital. International journal of environmental research and public health. 2021;18(21).
  • Referans10. Melku M, Asefa W, Mohamednur A, et al. Magnitude of Anemia in Geriatric Population Visiting Outpatient Department at the University of Gondar Referral Hospital, Northwest Ethiopia: Implication for Community-Based Screening. Current gerontology and geriatrics research. 2018;2018:9869343.
  • Referans11. Gaskell H, Derry S, Andrew Moore R, McQuay HJ. Prevalence of anaemia in older persons: systematic review. BMC Geriatr. 2008 Jan 14;8:1. doi: 10.1186/1471-2318-8-1. PMID: 18194534; PMCID: PMC2248585.
  • Referans12. Artz AS, Thirman MJ. Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):925-32. doi: 10.1093/gerona/glr090. Epub 2011 Jun 9. PMID: 21659341.).
  • Referans13. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-2268. Referans14. Busti F, Campostrini N, Martinelli N, Girelli D. Iron deficiency in the elderly population, revisited in the hepcidin era. Frontiers in pharmacology. 2014;5:83.
  • Referans15. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nature immunology. 2006;7(4):333-337.
  • Referans16. Price EA, Mehra R, Holmes TH, Schrier SL. Anemia in older persons: etiology and evaluation. Blood cells, molecules & diseases. 2011;46(2):159-165.
  • Referans17. Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S, Hemmelgarn BR. Impact of anemia on hospitalization and mortality in older adults. Blood. 2006;107(10):3841-3846.
  • Referans18. Ohta R, Ryu Y, Kitayuguchi J, Gomi T, Katsube T. Challenges and solutions in the continuity of home care for rural older people: A thematic analysis. Home health care services quarterly. 2020;39(2):126-139.
  • Referans19. Benoit JL, Benoit SW, de Oliveira MHS, Lippi G, Henry BM. Anemia and COVID-19: A prospective perspective. Journal of medical virology. 2021;93(2):708-711.
  • Referans20. Tettamanti M, Lucca U, Gandini F, et al. Prevalence, incidence and types of mild anemia in the elderly: the "Health and Anemia" population-based study. Haematologica. 2010;95(11):1849-1856.
  • Referans21. Hemauer SJ, Kingeter AJ, Han X, Shotwell MS, Pandharipande PP, Weavind LM. Daily Lowest Hemoglobin and Risk of Organ Dysfunctions in Critically Ill Patients. Critical care medicine. 2017;45(5):e479-e484.
  • Referans22. Tao Z, Xu J, Chen W, Yang Z, Xu X, Liu L, Chen R, Xie J, Liu M, Wu J, Wang H, Liu J. Anemia is associated with severe illness in COVID-19: A retrospective cohort study. Journal of medical virology. 2021;93(3):1478-1488.
  • Referans23. Hariyanto TI, Kurniawan A. Anemia is associated with severe coronavirus disease 2019 (COVID-19) infection. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2020;59(6):102926-102926.
  • Referans24. Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, Wang G, Fu W, Xiao J, Ding X, Li T, Xiao X, Li C.Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Annals of translational medicine. 2020;8(9):593.
  • Referans25. Foy BH, Carlson JCT, Reinertsen E, Padros I Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM. Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection. JAMA network open. 2020;3(9):e2022058.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Dahili Tıp Bilimleri Araştırma Yazıları
Yazarlar

Mercan Taştemur 0000-0003-0320-4095

Güneş Arık 0000-0002-4766-3982

Hilal Heybeli 0000-0003-1161-2961

Hande Selvi Öztorun 0000-0003-0343-8510

Kamile Silay 0000-0003-0384-4957

İhsan Ateş 0000-0003-2858-6229

Denizcan Hastürk 0000-0002-7318-6702

Büşra Betül Çağır 0000-0003-1183-0264

Rana Tuna Doğrul 0000-0001-9470-5113

Atacan Aras 0000-0001-5168-7285

Erhan Özenç 0000-0003-4250-4373

Proje Numarası yok
Yayımlanma Tarihi 31 Aralık 2022
Kabul Tarihi 27 Aralık 2022
Yayımlandığı Sayı Yıl 2022Cilt: 44 Sayı: 4

Kaynak Göster

AMA Taştemur M, Arık G, Heybeli H, Selvi Öztorun H, Silay K, Ateş İ, Hastürk D, Çağır BB, Tuna Doğrul R, Aras A, Özenç E. The Relationship Between Anemia and Mortality in Elderly COVID 19 Patients. CMJ. Aralık 2022;44(4):370-376. doi:10.7197/cmj.1168081