Editorial

The Confluence of Autoinflammation, Autoimmunity, and Peripheral Immune Tolerance: A New Chapter in Immunological Harmony

Volume: 47 Number: 4 December 31, 2025
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The Confluence of Autoinflammation, Autoimmunity, and Peripheral Immune Tolerance: A New Chapter in Immunological Harmony

Abstract

Abstract The 2025 Nobel Prize in Physiology or Medicine celebrated the discovery of mechanisms of peripheral immune tolerance, completing the immunological spectrum that spans autoinflammation and autoimmunity. This editorial contextualizes the award within decades of research illustrating how regulatory T cells (Tregs) and other tolerance mechanisms uphold self-integrity while sustaining host defense. Recent discoveries regarding transcriptional regulation, T-cell plasticity, and tumor immunology underscore the importance of immune balance in both health and disease.

Keywords

References

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  5. 5. Kuratani A, Okamoto M, Kishida K, Okuzaki D, Sasai M, Sakaguchi S, Arase H, Yamamoto M. Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity. Science. 2024 Nov 22;386(6724):eadn8608. doi: 10.1126/science.adn8608. Epub 2024 Nov 22. PMID: 39571033.

Details

Primary Language

English

Subjects

Medical Education

Journal Section

Editorial

Authors

Publication Date

December 31, 2025

Submission Date

December 3, 2025

Acceptance Date

December 19, 2025

Published in Issue

Year 2025 Volume: 47 Number: 4

IZ

https://izlik.org/JA36TR87ZC

Cite

RIS / Bibtex
AMA
1.Şahin A. The Confluence of Autoinflammation, Autoimmunity, and Peripheral Immune Tolerance: A New Chapter in Immunological Harmony. CMJ. 2025;47(4):1-2. https://izlik.org/JA36TR87ZC