Editoryal

The Confluence of Autoinflammation, Autoimmunity, and Peripheral Immune Tolerance: A New Chapter in Immunological Harmony

Cilt: 47 Sayı: 4 31 Aralık 2025
Cumhuriyet Tıp Dergisi Kapak
Cumhuriyet Tıp Dergisi
PDF İndir
EN TR

The Confluence of Autoinflammation, Autoimmunity, and Peripheral Immune Tolerance: A New Chapter in Immunological Harmony

Abstract

Abstract The 2025 Nobel Prize in Physiology or Medicine celebrated the discovery of mechanisms of peripheral immune tolerance, completing the immunological spectrum that spans autoinflammation and autoimmunity. This editorial contextualizes the award within decades of research illustrating how regulatory T cells (Tregs) and other tolerance mechanisms uphold self-integrity while sustaining host defense. Recent discoveries regarding transcriptional regulation, T-cell plasticity, and tumor immunology underscore the importance of immune balance in both health and disease.

Keywords

Kaynakça

  1. 1. Sakaguchi S, Mikami N, Wing JB, Tanaka A, Ichiyama K, Ohkura N. Regulatory T Cells and Human Disease. Annu Rev Immunol. 2020 Apr 26;38:541-566. doi: 10.1146/annurev-immunol-042718-041717. Epub 2020 Feb 4. PMID: 32017635.
  2. 2. Zeng H, Zhang R, Jin B, Chen L. Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance. Cell Mol Immunol. 2015 Sep;12(5):566-71. doi: 10.1038/cmi.2015.44. Epub 2015 Jun 8. PMID: 26051475; PMCID: PMC4579656.
  3. 3. Ichiyama K, Long J, Kobayashi Y, Horita Y, Kinoshita T, Nakamura Y, Kominami C, Georgopoulos K, Sakaguchi S. Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity. Immunity. 2024 Sep 10;57(9):2043-2060.e10. doi: 10.1016/j.immuni.2024.07.010. Epub 2024 Aug 6. PMID: 39111316.
  4. 4. Tay C, Tanaka A, Sakaguchi S. Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy. Cancer Cell. 2023 Mar 13;41(3):450-465. doi: 10.1016/j.ccell.2023.02.014. PMID: 36917950.
  5. 5. Kuratani A, Okamoto M, Kishida K, Okuzaki D, Sasai M, Sakaguchi S, Arase H, Yamamoto M. Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity. Science. 2024 Nov 22;386(6724):eadn8608. doi: 10.1126/science.adn8608. Epub 2024 Nov 22. PMID: 39571033.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Tıp Eğitimi

Bölüm

Editoryal

Yazarlar

Yayımlanma Tarihi

31 Aralık 2025

Gönderilme Tarihi

3 Aralık 2025

Kabul Tarihi

19 Aralık 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 47 Sayı: 4

IZ

https://izlik.org/JA36TR87ZC

Kaynak Göster

RIS / Bibtex
AMA
1.Şahin A. The Confluence of Autoinflammation, Autoimmunity, and Peripheral Immune Tolerance: A New Chapter in Immunological Harmony. CMJ. 2025;47(4):1-2. https://izlik.org/JA36TR87ZC