The real-world efficacy and safety of direct-acting oral antiviral treatment in chronic Hepatitis C Genotype 1 patients in Turkey

Erol Çakmak

doi:10.7197/223.vi.376221

TR EN

Türkiye’de kronik Hepatit C Genotip 1 hastalarında direkt-etkili oral antiviral tedavinin gerçek yaşamda etkinliği ve güvenliği

Öz

Amaç: Bu çalışmanın amacı, Türkiye'de ve dünyada kronik hepatit C virüsünün (HCV) en yaygın şekli olan genotip 1 hastalarında kullanılan paritaprevir / ritonavir, ombitasvir, dasabuvir (PrOD) ± ribavirin (RBV) ve ledipasvir / sofosbuvir (LDV / SOF) ± RBV kombinasyon rejimlerinin gerçek yaşamda etkinliğini ve güvenirliğini araştırmakdı.

Yöntem: Haziran 2016 ile Ekim 2017 yılları arasında, PrOD ± RBV veya LDV / SOF ± RBV tedavi rejimleri alan toplam 81 HCV genotipi 1 hasta dahil edildi. Hastalar demografik, klinik ve virolojik verileri, kalıcı virolojik yanıt (KVY) ve ayrıntılı yan etkiler değerlendirildi.

Bulgular: 81 HCV hastası, 35 (% 43.2) erkek, 46 (% 56.8) kadın olup ortalama yaş 62 idi. Hastalar Türkiye'de en sık görülen genotip olan genotip 1 ve alt genotipler % 12.3 genotip 1a ve % 87.7 genotip 1b idi. Kronik HCV genotip 1 hastalarının KVY oranı 79 (% 96.4), PrOD ± RBV hastalarında % 98.2 ve SOF / LDV ± RBV'de % 96 idi. Ayrıntılı yan etki 46 (% 56.8) hastada bildirildi. Hastalarda en sık görülen yan etkiler; 18 (% 22.2) kaşıntı, 17 yorgunluk (% 21) ve 16 (% 19.8) baş ağrısı idi.

Sonuç: Bu çalışmada bölgemizdeki tek bir merkezden elde edilen gerçek yaşam verilerine göre, kronik HCV genotip 1 hastalarında direkt etkili oral viral tedavi rejimleri ile yüksek KVY 12 yanıtı elde edildi ve mükemmel tolere edildiği görüldü.

Anahtar Kelimeler

Antiviral ajanlar,Hepatitis C kronik,güvenlik,kalıcı viral yanıt,kalıcı viral yanıt

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Erol Çakmak
Türkiye

Publication Date

March 20, 2018

Submission Date

January 8, 2018

Acceptance Date

February 25, 2018

Published in Issue

Year 1970 Volume: 40 Number: 1

DOI

https://doi.org/10.7197/223.vi.376221

IZ

https://izlik.org/JA39ES74FP

Cite

RIS / Bibtex

AMA

1.Çakmak E. The real-world efficacy and safety of direct-acting oral antiviral treatment in chronic Hepatitis C Genotype 1 patients in Turkey. CMJ. 2018;40(1):56-64. doi:10.7197/223.vi.376221

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The real-world efficacy and safety of direct-acting oral antiviral treatment in chronic Hepatitis C Genotype 1 patients in Turkey

Türkiye’de kronik Hepatit C Genotip 1 hastalarında direkt-etkili oral antiviral tedavinin gerçek yaşamda etkinliği ve güvenliği

Öz

Anahtar Kelimeler