The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

Nursah Basol; Aslı Yasemen Savas; Ayfer Meral; Oytun Erbas

doi:10.7197/223.vi.407571

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Güçlü antikosidan kurkuminin sisplatinin neden olduğu karaciğer ve böbrek hasarında önemli etkileri

Öz

Amaç: Sisplatin (CIS) sıklıkla kullanılan oldukça güçlü bir anti kanser ajandır. Sisplatinin toksik etkileri kullanımını sınırlandırmaktadır. Sunulan bu deneysel çalışmada, sisplatinin nefrotoksik ve hepatotoksik yan etkilerine karşı kurkuminin (CUR) etkilerinin incelenmesi amaçlanmıştır.

Yöntem: Sıçanlar her biri 7’şerli toplam 3 gruba ayrıldı. İlk grup, control grubu olarak, ikinci grup CIS (6 mg/kg, i.p)+ salin grubu ve 3. grup CIS (6 mg/kg, i.p) + CUR (100 mg/kg i.p) olarak belirlendi. Sisplatin tek doz olarak ve kurkumin ise 3 gün boyunca sıçanlara verildi. 3 gün sonra, karaciğer ve böbrek dokuları ve kan örnekleri histopatolojik ve biyokimyasal tekniklerle analiz edildi.

Bulgular: Sisplatin+ kurkumin gurubunda BUN ve ALT değerleri sadece sisplatin uygulanan gruba göre daha düşük bulundu. Bunun yanında, SOD ve GSH düzeyleri sadece sisplatin verilen grupta CIS+CUR grubuna göre daha yüksekti. Karaciğer ve böbrek dokusunda histopatolojik olarak kurkuminin yararlı etkileri gözlendi.

Sonuç: Sisplatin böbrek ve karaciğer dokuları üzerinde güçlü bir toksik etkiye sahiptir. Sunulan bu çalışma; kurkuminin, nefrotoksik ve hepatotoksik yan etkileri iyileştirmede önemli bir etkisi olduğunu öne sürmektedir.

Anahtar Kelimeler

Sisplatin,kurkumin,nefrotoksisite,hepatotoksisite

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Nursah Basol ^*

Aslı Yasemen Savas

Ayfer Meral

Oytun Erbas

Publication Date

March 20, 2018

Submission Date

November 23, 2017

Acceptance Date

January 18, 2018

Published in Issue

Year 1970 Volume: 40 Number: 1

DOI

https://doi.org/10.7197/223.vi.407571

IZ

https://izlik.org/JA57HF47DN

Cite

RIS / Bibtex

AMA

1.Basol N, Savas AY, Meral A, Erbas O. The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury. CMJ. 2018;40(1):9-18. doi:10.7197/223.vi.407571

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The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

Güçlü antikosidan kurkuminin sisplatinin neden olduğu karaciğer ve böbrek hasarında önemli etkileri

Öz

Anahtar Kelimeler