The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

Nursah Basol; Aslı Yasemen Savas; Ayfer Meral; Oytun Erbas

doi:10.7197/223.vi.407571

TR EN

The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

Abstract

Objective: Cisplatin (CIS) is a potent anticancer drug that uses commonly. The toxic effects of CIS limit its usage. In the present experimental study, it is aimed to evaluate effects of curcumin (CUR) on CIS induced hepatotoxicity and nephrotoxicity.

Method: The rats were separated into three groups as each composed of 7 rats. First one is control group, the second is the CIS (6 mg/kg, i.p) + saline group, and third is the CIS (6 mg/kg, i.p) + CUR (100 mg/kg i.p) group. CIS was given at single dose and CUR was given for 3 days. After 3 days, kidney, liver and blood samples were analyzed with histopathological and biochemical technics.

Results: In CIS+ CUR group, there was decline in levels of Blood urea nitrogen (BUN), alanine aminotransferase (ALT) ALT and compared with CIS group. Besides, superoxide dismutase (SOD) and glutathione (GSH) levels were found increased as compared with CIS group. The ameliorating effects of CUR were presented with histopathological findings.

Conclusions: CIS has serious toxicity on kidney and liver and oxidative stress play an important role on toxicity. The present study suggests that CUR has important healing effects on nephrotoxicity and hepatotoxicity of CIS.

Keywords

Cisplatin,curcumin,nephrotoxicity,hepatotoxicity

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Nursah Basol ^*

Aslı Yasemen Savas

Ayfer Meral

Oytun Erbas

Yayımlanma Tarihi

20 Mart 2018

Gönderilme Tarihi

23 Kasım 2017

Kabul Tarihi

18 Ocak 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 40 Sayı: 1

DOI

https://doi.org/10.7197/223.vi.407571

IZ

https://izlik.org/JA57HF47DN

Kaynak Göster

RIS / Bibtex

AMA

1.Basol N, Savas AY, Meral A, Erbas O. The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury. CMJ. 2018;40(1):9-18. doi:10.7197/223.vi.407571

Cited By

Curcumin extraction from turmeric plant using magnetic Fe3O4 nanoparticles

Demiroglu Science University Florence Nightingale Journal of Medicine

https://doi.org/10.5606/fng.btd.2021.25071

The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

Güçlü antikosidan kurkuminin sisplatinin neden olduğu karaciğer ve böbrek hasarında önemli etkileri

Öz

Anahtar Kelimeler

The valuable effects of potent antioxidant curcumin in cisplatin induced liver and kidney injury

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Curcumin extraction from turmeric plant using magnetic Fe3O4 nanoparticles