DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE
Abstract
Hypertension, defined as high blood pressure, is a common medical condition leading to cardiovascular disability and premature deaths. Blood pressure control in an efficient way are assumed to the main targets to prevent hypertension. Since conventional dosage forms (e.g. immediate release tablets, capsules, etc.) show some limitation, greater attention is being paid on designing the modified drug release systems. Modified release is defined as drug releasing from dosage form some time after the administration or in prolonged period of time. In this study, we aimed to design metoprolol tartarate loaded chitosan microparticles to obtained modified drug release. Chitosan microparticles produced via ionic gelation with tripolyphosphate as a crosslinking agent. Prepared formulations were characterized and metoprolol tartarate was loaded into the optimal blank microspheres. The entrapment efficiency, drug loading, cell viability assay and in vitro drug release were investigated. Optimum formulation was spherical and had 81% of yield and 75.373±7.384µm particle size. 16 mg of metoprolol tartarate could be loaded into microparticles and drug release could be maintained for 48 hours.
Keywords
References
- Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Publication Date
December 29, 2018
Submission Date
December 17, 2018
Acceptance Date
December 23, 2018
Published in Issue
Year 2018 Volume: 40 Number: 4