DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE
Abstract
Hypertension, defined as high blood pressure, is a common medical condition leading to cardiovascular disability and premature deaths. Blood pressure control in an efficient way are assumed to the main targets to prevent hypertension. Since conventional dosage forms (e.g. immediate release tablets, capsules, etc.) show some limitation, greater attention is being paid on designing the modified drug release systems. Modified release is defined as drug releasing from dosage form some time after the administration or in prolonged period of time. In this study, we aimed to design metoprolol tartarate loaded chitosan microparticles to obtained modified drug release. Chitosan microparticles produced via ionic gelation with tripolyphosphate as a crosslinking agent. Prepared formulations were characterized and metoprolol tartarate was loaded into the optimal blank microspheres. The entrapment efficiency, drug loading, cell viability assay and in vitro drug release were investigated. Optimum formulation was spherical and had 81% of yield and 75.373±7.384µm particle size. 16 mg of metoprolol tartarate could be loaded into microparticles and drug release could be maintained for 48 hours.
Keywords
Kaynakça
- Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.
Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
29 Aralık 2018
Gönderilme Tarihi
17 Aralık 2018
Kabul Tarihi
23 Aralık 2018
Yayımlandığı Sayı
Yıl 2018 Cilt: 40 Sayı: 4