Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

Gökhan Arslan; Erdal Ağar

doi:10.7197/223.vi.531144

EN TR

Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity

Abstract

Objective: Epilepsy is a neurological disease characterized by seizures that can affect all age groups. Experimental epilepsy models have been used in order to prevent and treat epileptic seizures. Bisphenol A (BPA) is found in the plastics that are used in our daily lives, and causes harmful effects on the central nervous system. In this study, we aimed to investigate the effect of BPA in penicillin-induced epileptiform activity.

Method: Male Wistar rats weighing 205 ± 220 grams were separated into 4 groups: Control (n=7), 125 μg/kg BPA (n=7), 250 μg/kg BPA (n=7) and 500 μg/kg BPA (n=7). Rats were anesthetized with urethane, and were fixed to a stereotaxic device. With the stereotaxic guidance, an electrode was placed over the left somotomotor cortex and it connected to the recorder. 500 IU penicillin G was administered intracortically for induction of epileptiform activity. After 30 minutes from penicillin injection, the doses of BPA or olive oil were administered intraperitoneally and electrocorticography recording continued for 180 minutes after drug injection.

Results: BPA, at a dose of 125 μg/kg, did not significantly change either the means of spike frequency or amplitude when compared to the control group. BPA, at the doses of 250 and 500 μg/kg, showed proconvulsant activity by increasing the mean spike frequency in the 50 and 40 minutes (respectively) until the end of the experiment without changing the amplitude.

Conclusions: The results of the present study provide electrophysiological evidence that BPA increase the epileptiform activity. Therefore, we suggest that epilepsy patients should avoid exposure to BPA.

Keywords

Epilepsy,Epileptiform activity,Penicillin,Seizure,Bisphenol A

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Gökhan Arslan ^*
0000-0003-4186-2478
Türkiye

Erdal Ağar
Türkiye

Publication Date

June 30, 2019

Submission Date

February 22, 2019

Acceptance Date

May 7, 2019

Published in Issue

Year 2019 Volume: 41 Number: 2

DOI

https://doi.org/10.7197/223.vi.531144

IZ

https://izlik.org/JA43PX27XP

Cite

RIS / Bibtex

APA

Arslan, G., & Ağar, E. (2019). Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity. Cumhuriyet Medical Journal, 41(2), 244-249. https://doi.org/10.7197/223.vi.531144

AMA

1.Arslan G, Ağar E. Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity. CMJ. 2019;41(2):244-249. doi:10.7197/223.vi.531144

Chicago

Arslan, Gökhan, and Erdal Ağar. 2019. “Proconvulsant Effect of Bisphenol A in Penicillin Induced Epileptiform Activity”. Cumhuriyet Medical Journal 41 (2): 244-49. https://doi.org/10.7197/223.vi.531144.

EndNote

Arslan G, Ağar E (June 1, 2019) Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity. Cumhuriyet Medical Journal 41 2 244–249.

IEEE

[1]G. Arslan and E. Ağar, “Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity”, CMJ, vol. 41, no. 2, pp. 244–249, June 2019, doi: 10.7197/223.vi.531144.

ISNAD

Arslan, Gökhan - Ağar, Erdal. “Proconvulsant Effect of Bisphenol A in Penicillin Induced Epileptiform Activity”. Cumhuriyet Medical Journal 41/2 (June 1, 2019): 244-249. https://doi.org/10.7197/223.vi.531144.

JAMA

1.Arslan G, Ağar E. Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity. CMJ. 2019;41:244–249.

MLA

Arslan, Gökhan, and Erdal Ağar. “Proconvulsant Effect of Bisphenol A in Penicillin Induced Epileptiform Activity”. Cumhuriyet Medical Journal, vol. 41, no. 2, June 2019, pp. 244-9, doi:10.7197/223.vi.531144.

Vancouver

1.Gökhan Arslan, Erdal Ağar. Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity. CMJ. 2019 Jun. 1;41(2):244-9. doi:10.7197/223.vi.531144