Proconvulsant effect of bisphenol A in penicillin induced epileptiform activity
Abstract
Objective: Epilepsy is a neurological disease characterized by seizures that can affect all age groups. Experimental epilepsy models have been used in order to prevent and treat epileptic seizures. Bisphenol A (BPA) is found in the plastics that are used in our daily lives, and causes harmful effects on the central nervous system. In this study, we aimed to investigate the effect of BPA in penicillin-induced epileptiform activity.
Method: Male Wistar rats weighing 205 ± 220 grams were separated into 4 groups: Control (n=7), 125 μg/kg BPA (n=7), 250 μg/kg BPA (n=7) and 500 μg/kg BPA (n=7). Rats were anesthetized with urethane, and were fixed to a stereotaxic device. With the stereotaxic guidance, an electrode was placed over the left somotomotor cortex and it connected to the recorder. 500 IU penicillin G was administered intracortically for induction of epileptiform activity. After 30 minutes from penicillin injection, the doses of BPA or olive oil were administered intraperitoneally and electrocorticography recording continued for 180 minutes after drug injection.
Results: BPA, at a dose of 125 μg/kg, did not significantly change either the means of spike frequency or amplitude when compared to the control group. BPA, at the doses of 250 and 500 μg/kg, showed proconvulsant activity by increasing the mean spike frequency in the 50 and 40 minutes (respectively) until the end of the experiment without changing the amplitude.
Conclusions: The results of the present study provide electrophysiological evidence that BPA increase the epileptiform activity. Therefore, we suggest that epilepsy patients should avoid exposure to BPA.
Keywords
Kaynakça
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Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
30 Haziran 2019
Gönderilme Tarihi
22 Şubat 2019
Kabul Tarihi
7 Mayıs 2019
Yayımlandığı Sayı
Yıl 2019 Cilt: 41 Sayı: 2