Sivas yöresine özgü bazı bitki özütlerinin anti neoplastik etkileri

Mustafa Turan; Atalay Sökmen; Kürşat Karadayı; Zübeyde Akın Polat; Metin Şen

EN TR

Sivas yöresine ait bazı bitki özütlerinin antineoplastik etkileri

Abstract

Özet

Amaç. Bitkiler antineoplastik özelliği bilinen bazı ilaçların ham maddesini oluşturmaktadır. Bu çalışmada yöremize özgü ve halk arasında da antineoplastik özellikleri olduğuna dair şüpheler bulunan bitkilerin özütlerinin bu özellikleri araştırılmıştır. Yöntem.In vitro sitotoksisite çalışmaları MDA-MB-231, MDA-MB-468 hazır kanser hücre serilerine karşı “Tripan mavisi ekstraksiyon yöntemi” kullanılarak yapılmıştır. Bulgular. Bu çalışmalar sonrasında Salvia cryptantha, Ferula Orientalis, Allium sivasicum, Helichrysum arenarium subsp. aucheri, Thymus pectinatus, Tanacetum parthenium, Achillea teretifolia, Pelargonium endlicherianum, Origanum acutidens, Melissa officinalis, Berberis vulgaris, Rhodiola rosae ve Urtica dioica’da umut vaadecek antineoplastik sonuçlara ulaşılmıştır. Sonuç. Bu bitkiler üzerinde ileri düzeyde çalışmalardan sonra elde edilecek ajanlar, kanser hastalarının tedavilerinde ve/veya kansere karşı kemoprotektif olarak yer alabilir.

Anahtar sözcükler: Kanser, antineoplastik, bitki özütleri

Abstract

Aim. Plants are well known source of some antineoplastic drugs. In this study, we investigated the antineoplastic potential of some plant extracts which are endemic in Sivas. Methods. In vitro cytotoxicity studies were performed with “Trypan blue exclusion assay” against MDA-MB-231, MDA-MB-468 cell lines. Results. After these studies, we detected hopeful antitumoral activities in Salvia cryptantha, Ferula Orientalis, Allium sivasicum, Helichrysum arenarium subsp. aucheri, Thymus pectinatus, Tanacetum parthenium, Achillea teretifolia, Pelargonium endlicherianum, Origanum acutidens, Melissa officinalis, Berberis vulgaris, Rhodiola rosae and Urtica dioica extracts. Conclusion. Further studies on these plant extracts were needed. The agents which will be detected at the end of those studies, may be helpful in the treatment of some cancer patients or useful in the chemoprevention of cancer.

Keywords: Cancer, antineoplastic, plant extracts

Keywords

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Sivas yöresine özgü bazı bitki özütlerinin anti neoplastik etkileri

Öz

Amaç. Bitkiler antineoplastik özelliği bilinen bazı ilaçların ham maddesini oluşturmaktadır. Bu çalışmada yöremize özgü ve halk arasında da antineoplastik özellikleri olduğuna dair şüpheler bulunan bitkilerin özütlerinin bu özellikleri araştırılmıştır. Yöntem.In vitro sitotoksisite çalışmaları MDA-MB-231, MDA-MB-468 hazır kanser hücre serilerine karşı “Tripan mavisi ekstraksiyon yöntemi” kullanılarak yapılmıştır. Bulgular. Bu çalışmalar sonrasında Salvia cryptantha, Ferula Orientalis, Allium sivasicum, Helichrysum arenarium subsp. aucheri, Thymus pectinatus, Tanacetum parthenium, Achillea teretifolia, Pelargonium endlicherianum, Origanum acutidens, Melissa officinalis, Berberis vulgaris, Rhodiola rosae ve Urtica dioica‟da umut vaadecek antineoplastik sonuçlara ulaşılmıştır. Sonuç. Bu bitkiler üzerinde ileri düzeyde çalışmalardan sonra elde edilecek ajanlar, kanser hastalarının tedavilerinde ve/veya kansere karşı kemoprotektif olarak yer alabilir

Anahtar Kelimeler

Kanser, antineoplastik, bitki özütleri

References

Mantle D, Lennard TW, Pickering AT. Therapeutic applications of medicinal plants in the treatment of breast cancer : a review of their pharmacology, efficacy and tolerability. Adverse Drug React Toxicol Rev 2000; 19: 233-40.
Rodica S, Liat D, Judith R, Yoram B, Shai Y and Ilan C. Tamoxifen Modulates Apoptotic Pathways in Primary Endometrial Cell Cultures Experimental Therapeutics, Preclinical Pharmacology Clinical Cancer Research 2001; 7, 415-20.
Dran G, Luthy IA, Molinolo AA,Montecchia F. Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma. Breast Cancer Res Treat. 1995; 35:173-86.
Wang X, Bastow KF, Sun CM, Lin YL, Yu HJ, Don MJ, Wu TS, Nakamura S, Lee KH. Antitumor Agents. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza. J Med Chem. 2004; 47:5816-9.
Yang L, Chung J, Kung H.Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells. J Biomedical Science 2005; 12: 347-61.
Wu W, Chang W, Chen C. Cytotoxic activities of Tanshinones against human carcinoma cell lines. Am J Chinese Med. 1991; 19:207-16.
Halinska A, Belej T. Cytotoxic mechanisms of antitumor quinones in parental and resistant lymphoblasts. Br J Cancer –Supp. 1996; 27:23-7.
Mallikarjuna GU, Dhanalakshmi S, Raisuddin S, Rao AR. Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. Breast Cancer Res Treat. 2003; 81:1-10.

Unnikrishnan MC, Kuttan R. Tumour reducing and anticarcinogenic activity of selected spices. Cancer Lett. 1990;51: 85-9.
Saleem M, Alam A, Sultana S. Asafoetida inhibits early events of carcinogenesis: a chemopreventive study. Life Sci. 2001; 68:1913-21.
Tamemoto K, Takaishi Y, Kawazoe K, Honda G, Ito M, Kiuchi F, Takeda Y, Kodzhimatov OK, Ashurmetov O, Shimizu K, Nagasawa H, Uto Y, Hori H. An unusual sesquiterpene derivative from Ferula kuhistanica. J Nat Prod. 2002; 65:1323-4.
Biedermann B. Garlic--a "secret miracle of God"? Schweiz Rundsch Med Prax. 1995; 84:7-10.
Shirin H, Pinto J. Antiproliferative effects of S-Allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide. Cancer Res. 2001; 61: 725-31.
Pinto T, Lapsia S, Shah A. Antiproliferative effects of garlic derived and other Allium related compounds. In: American Institute For Cancer Research(eds). Nutrition and Cancer Prevention: New Insights into Role of Phytochemicals, pp.83-106; New York:Kluwer Academic/Plenum Publishers, 2000.
Lund T, Stokke T, Olsen OE, Fodstad O. Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis. Br J Cancer. 2005; 92:1773-81.
Keiss H, Verena M, Hartung T. Garlic (Allium sativum) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-KB activity. Biochemical and molecular actions of nutrients. 2003; 5: 2171-5.
Meyer JJ, Afolayan AJ, Taylor MB, Erasmus D. Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J Ethnopharmacol. 1997; 56:165-9.
Bocharova OA, Karpova RV, Golubeva VA, Kasatkina NN, Kurennaia ON, A toxicological study of the preparation Phytomix-40. Gig Sanit. 1999; 5:60-1.
Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001 ;8:759-66.
Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med. 1982 ;8:653-60.
Koshiura R, Miyamoto K, Ikeya Y, Taguchi H. Antitumor activity of methanol extract from roots of Agrimonia pilosa Ledeb. Jpn J Pharmacol. 1985; 38:9-16.
Miyamoto K, Kishi N, Koshiura R. Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa Ledeb., on transplantable rodent tumors. Jpn J Pharmacol. 1987; 43:187-95.
Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sokmen A, Akpulat HA. Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). J Ethnopharmacol. 2003; 87:215-20.
Kundakovic T, Dobric S, Bokonjic D, Dragojevic-Simic V, Kilibarda V,Kovacevic N. Anti-inflammatory and anti-ulcer activity of Achillea alexandri-regis. Pharmazie. 2000; 55:866-7.
Kundakovic T, Stanojkovic T, Juranic Z, Kovacevic N. Cytotoxic and antioxidant activity of Achillea alexandri-regis. Pharmazie. 2005; 60:319-20.
Fang HJ, Su XL, Liu HY, Chen YH, Ni JH. Studies on the chemical components and anti-tumor action of the volatile oils from Pelargonium graveoleus. Yao Xue Xue Bao. 1989;24:366-71.
de Sousa AC, Alviano DS, Blank AF, Alves PB, Alviano CS, Gattass CR. Melissa officinalis L. essential oil: antitumoral and antioxidant activities. J Pharm Pharmacol. 2004;56:677-81.
Dudai N, Weinstein Y, Krup M, Rabinski T, Ofir R. Citral is a new inducer of caspase-3 in tumor cell lines. Planta Med. 2005;71:484-8.
Arcila-Lozano CC, Loarca-Pina G, Lecona-Uribe S, Gonzalez de Mejia E. Oregano: properties, composition and biological activity. Arch Latinoam Nutr. 2004;54:100-11.
Goun E, Cunningham G, Solodnikov S, Krasnykch O, Miles H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia. 2002;73:692-4.
Yin X, Zhou J, Jie C, Xing D, Zhang Y. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci. 2004,17;75:2233-44.
32.Lee TK, Lee DK, Kim DI, Lee YC, Chang YC, Kim CH. Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal smooth muscle cell proliferation through cell cycle analysis. Int Immunopharmacol. 2004;4:447-54.
Zhang DY, Wu J, Ye F, Xue L, Jiang S, Yi J, Zhang W, Wei H, Sung M, Wang W, Li X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res. 2003;15:4037-43.
Chopra RN, Nayar SL, Chopra IC, editors. Glossary of Indian medicinal plants. New Delhi: Council of scientific and Industrial Research, 1956; p: 64.
Hazra B, Sarkar R, Roy P. Tumor inhibitory activity of chiory root extract against Ehrlich‟s ascites carcinoma in mice. Fitoterapia 2002; 73:730-3.
Betsy B. Singh Berberine. Alternative Medicine Review, 2000;5:175-7.
Fukuda K, Hibiya Y, Mutoh M. Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Med 1999;65:381-3.
Lin JG, Chung JG. Effects of berberine on arylamine N-acetyltransferase activity in human colon tumor cells. Am J Chin Med 1999;27:265-75.
Fukuda K, Hibiya Y, Mutoh M. Inhibition by berberine of COX-2 transcriptional activity in human colon tumor cells. J Ethnopharmacol 1999;66:227-33.
Konrad L, Muller HH, Lenz C, Laubinger H, Aumuller G, Lichius JJ. Antiproliferative effect on human prostate cancer cells by a stinging netle root (Urtica dioica) extract. Planta Med. 2000;66:44-7.
Durak I, Biri H, Devrim E, Sozen S, Avci A. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol Ther. 2004 ;3:855-7.
Dement'eva LA, Iaremenko KV. Effect of a Rhodiola extract on the tumor process in an experiment. Vopr Onkol. 1987;33:57-60.
Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001;6:293-302.
Udintsev SN, Shakhov VP.Decrease in the growth rate of Ehrlich's tumor and Pliss' lymphosarcoma with partial hepatectomy. Vopr Onkol. 1989;35:1072-5.
Razina TG, Zueva EP, Amosova EN, Krylova SG. Medicinal plant preparations used as adjuvant therapeutics in experimental Oncology. Eksp Klin Farmakol. 2000;63:59-61.
Udintsev SN, Krylova SG, Fomina TI. The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich's adenocarcinoma to the liver in mice. Vopr Onkol. 1992;38:1217-22.
Zhao X, Zuo L, Zhong ZQ. Rhodiola sachalinensis suppresses T241 fibrosarcoma tumor cells proliferation in vitro and growth in vivo. Zhong Yao Cai. 2008;31:1377-80.
Tu Y, Roberts L, Shetty K, Schneider SS. Rhodiola crenulata induces death and inhibits growth of breast cancer cell lines. J Med Food. 2008 ;11:413-23.
Faleiro ML, Miguel MG, Ladeiro F, Venancio F, Tavares R, Brito JC, Antimicrobial activity of essential oils isolated from Portuguese endemic species of Thymus. Lett Appl Microbiol. 2003;36:35-40.
Vardar-Unlu G, Candan F, Sokmen A, Daferera D, Polissiou M, Sokmen M, Donmez E, Tepe B. Antimicrobial and antioxidant activity of the essential oil and methanol extracts of Thymus pectinatus Fisch. et Mey. Var. pectinatus (Lamiaceae). J Agric Food Chem. 2003;51:63-7.
Pina-Vaz C, Goncalves Rodrigues A, Pinto E, Costa-de-Oliveira S, Tavares C,Salgueiro L, Cavaleiro C, Goncalves MJ, Martinez-de-Oliveira J. Antifungal activity of Thymus oils and their major compounds. J Eur Acad Dermatol Venereol. 2004;18:73-8.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Mustafa Turan

Atalay Sökmen

Kürşat Karadayı

Zübeyde Akın Polat

Metin Şen

Publication Date

March 11, 2010

Submission Date

October 14, 2009

Acceptance Date

-

Published in Issue

Year 2010 Volume: 32 Number: 1

IZ

https://izlik.org/JA74US89BT

Cite

RIS / Bibtex

AMA

1.Turan M, Sökmen A, Karadayı K, Akın Polat Z, Şen M. Sivas yöresine özgü bazı bitki özütlerinin anti neoplastik etkileri. CMJ. 2010;32(1):9-18. https://izlik.org/JA74US89BT