Diabetik polinöropatik hastalarda memantinin ağrı üzerine etkinliği

Şeyda Gökçe; Burhanettin Çiğdem; Aytekin Akyüz; Ertuğrul Bolayır; Suat Topaktaş

doi:10.7197/cmj.v36i4.5000071418

EN TR

Effect of memantine on painful in the diabetic polyneuropathic patients

Abstract

Diabetic peripheral neuropathy (DPN) is one of the most frequent chronic pain symptoms. Several therapeutic modalities have been used for the patients with DPN. In recent years, NMDA receptor antagonists for modulation of excitatory transmission at primary afferent spino-thalamic neuron synapses are being used. It has been shown that NMDA receptor antagonists are as effective as opioid analgesics in cases with chronic pain. The aim of this study was to investigate on the pain effectiveness of NMDA receptor antagonist Memantin at two different doses prospectively. Twenty four type 2 diabetic neuropathy patients were included into the study. The diagnosis of diabetic neuropathy was based on clinical signs and symptoms (history, clinical examination of muscle strength, sensorial and deep tendon reflexes), and electrophysiological tests. Pain complaints of the patients were evaluated by using visual pain scala before and after the treatment. Patients were administered 10 mg Memantin for the first week followed by then 20 mg for consecutive 6 week. Without interruption of treatment 30 mg Memantin for one week and then 40 mg Memantin for 6 week were administered. There was a significant improvement in both treatment groups as compared to control group. Between the treatment groups was significant. It was concluted that; Memantin was effective in reducing neuropathic pain in patients with DPN.

Keywords

Diabetik polinöropatik hastalarda memantinin ağrı üzerine etkinliği

Öz

Diyabetik periferal nöropati (DPN) klinik pratikte en sık karşılaşılan kronik nöropatik ağrı semptomlarından birisidir. Diyabetik nöropatili hastalarda çeşitli tedavi yöntemleri denenmektedir. Son yıllarda primer afferent-spinotalamik nöron sinapslarında eksitatör transmisyonun modülasyonu için N-methyl-D-aspartate (NMDA) reseptör antagonistleri kullanılmaktadır. NMDA reseptör antagonistlerinin kronik ağrı durumlarında opioid analjezikler kadar etkin olduğu da gösterilmiştir. Bu çalışmada diabetik polinöropatili hastalarda prospektif olarak NMDA reseptör antagonisti Memantin’in farklı iki dozda, ağrı üzerine olan etkinliğini değerlendirmeyi amaçladık. Tip 2 diyabetli ve diabetik nöropatisi olan 24 hasta çalışmaya dahil edildi. Diyabetik nöropati tanısı klinik (anamnez, motor, duyusal ve refleks muayenesi) ve elektrofızyolojik testler ile konuldu. Hastaların ağrı şikayetleri tedavi öncesi ve sonrası Vizüel Ağrı Skalası (VAS) ile değerlendirildi. Hastalara birinci hafta 10 mg, daha sonra altı hafta boyunca 20 mg memantin verildi. Yedinci hafta sonunda hastalar tekrar değerlendirildi. Tedaviye ara vermeksizin bir hafta 30 mg, daha sonra altı hafta boyunca 40 mg memantin uygulandı. Her iki tedavi grubunda kontrol grubuna kıyasla VAS değerlerinde anlamlı düzelme gözlenirken, tedavi grupları arasındaki farkda önemli bulundu. Sonuç olarak diyabetik polinöropatide Memantin tedavisi nöropatik ağrının tedavisinde düzelme sağlamaktadır

Anahtar Kelimeler

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Şeyda Gökçe

Burhanettin Çiğdem

Aytekin Akyüz

Ertuğrul Bolayır

Suat Topaktaş

Publication Date

October 20, 2014

Submission Date

October 20, 2014

Acceptance Date

-

Published in Issue

Year 2014 Volume: 36 Number: 4

DOI

https://doi.org/10.7197/cmj.v36i4.5000071418

IZ

https://izlik.org/JA75KP57DB

Cite

RIS / Bibtex

AMA

1.Gökçe Ş, Çiğdem B, Akyüz A, Bolayır E, Topaktaş S. Diabetik polinöropatik hastalarda memantinin ağrı üzerine etkinliği. CMJ. 2014;36(4):474-478. doi:10.7197/cmj.v36i4.5000071418