The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies

Oktay Bulur; Evrim Kahramanoğlu Aksoy; Gülçin Güler Şimşek; Murat Eser; Zeliha Asiltürk Lülleci; Kürşat Dal; Metin Uzman

doi:10.7197/cmj.980147

EN

The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies

Abstract

Objective: Several factors play role in colorectal carcinogenesis. Among these factors, helicobacter pylori infection is supposed to be one of the causative factors. Previous studies were focused on investigation of the relationship between helicobacter pylori existence and colon carcinomas by particular serological diagnostic tests. The aim of our study was to determine the effect of the helicobacter pylori infection and the severity of inflammation related to this infection on the colon carcinomas and non carcinoma colon mass lesions(tubular adenoma, tubulovillous adenoma, hyperplastic polyp).

Method: A retrospective study was conducted at Kecioren Teaching - Research Hospital between 2010 to 2018. The files of 657 patients who underwent colonoscopy and were diagnosed as colon benign or malign mass lesions were examined retrospectively from the hospital database. Two hundred five patients who had undergone both upper gastrointestinal endoscopy and colonoscopies were included in the study. The presence and severity of inflammation due to helicobacter pylori were evaluated by histopathological examination of biopsies taken during upper gastrointestinal endoscopy. The severity of H. pylori inflammation was graded according to the Sydney classification

Results: In the comparison of colon carcinoma with other colon mass lesions group, there was no statistical significance in terms of gender (P= 0.094) and H. pylori serology (P= 0.998). However, the degree of inflammation was significantly high in patients with colon carcinoma than other colon mass lesions (P< 0.001).

Conclusions: The fact that the severity of helicobacter pylori inflammation is higher in patients with colon carcinoma than patients with non-carcinoma colonic mass lesions suggests that inflammation due to helicobacter pylori may be more important than the presence of helicobacter pylori in the carcinogenesis of colon cancer.

Keywords

References

Referans1. Fu L, Xie C. A lucid review of Helicobacter pylori-induced DNA damage in gastric cancer. Helicobacter. 2019;24(5):e12631. doi: 10.1111/hel.12631. PubMed PMID: 31295756.
Referans2. Jessurun J. Helicobacter pylori: an evolutionary perspective. Histopathology. 2021;78(1):39-47. doi: 10.1111/his.14245. PubMed PMID: 33382492.
Referans3. Juarez-Salcedo LM, Sokol L, Chavez JC, Dalia S. Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment. Cancer Control. 2018;25(1):1073274818778256. doi: 10.1177/1073274818778256. PubMed PMID: 29779412; PubMed Central PMCID: PMCPMC6028178.
Referans4. Guo Y, Liu W, Wu J. Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis. J Cancer Res Ther. 2016;12(Supplement):C229-C32. doi: 10.4103/0973-1482.200744. PubMed PMID: 28230023.
Referans5. Waluga M, Kukla M, Zorniak M, Bacik A, Kotulski R. From the stomach to other organs: Helicobacter pylori and the liver. World J Hepatol. 2015;7(18):2136-46. doi: 10.4254/wjh.v7.i18.2136. PubMed PMID: 26328025; PubMed Central PMCID: PMCPMC4550868.
Referans6. Globocan 2018. wwwuiccorg/new-global-cancer-data-globocan-2018. 2018.
Referans7. Wong MC, Ding H, Wang J, Chan PS, Huang J. Prevalence and risk factors of colorectal cancer in Asia. Intestinal research. 2019;17(3):317-29. doi: 10.5217/ir.2019.00021. PubMed PMID: 31085968; PubMed Central PMCID: PMC6667372.
Referans8. Zuo Y, Jing Z, Bie M, Xu C, Hao X, Wang B. Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis. Medicine. 2020;99(37):e21832. doi: 10.1097/MD.0000000000021832. PubMed PMID: 32925719; PubMed Central PMCID: PMC7489651.

Referans9. Bresalier RS. ColorectalCancer. Sleisenger and Fordtran's Gastrointestinal and Liver Disease,Elsevier. 15th June 2020 2(ColorectalCancer):2108-52.
Referans10. Liu X, Cheng Y, Shao L, Ling Z. Alterations of the Predominant Fecal Microbiota and Disruption of the Gut Mucosal Barrier in Patients with Early-Stage Colorectal Cancer. BioMed research international. 2020;2020:2948282. doi: 10.1155/2020/2948282. PubMed PMID: 32280686; PubMed Central PMCID: PMC7114766 commercial or financial relationships that could be construed as a potential conflict of interest.
Referans11. Wu Y, Shi L, Li Q, Wu J, Peng W, Li H, et al. Microbiota Diversity in Human Colorectal Cancer Tissues Is Associated with Clinicopathological Features. Nutrition and cancer. 2019;71(2):214-22. doi: 10.1080/01635581.2019.1578394. PubMed PMID: 30843732.
Referans12. Tozun N, Vardareli E. Gut Microbiome and Gastrointestinal Cancer: Les liaisons Dangereuses. J Clin Gastroenterol. 2016;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S191-S6. doi: 10.1097/MCG.0000000000000714. PubMed PMID: 27741173.
Referans13. Gao R, Kong C, Li H, Huang L, Qu X, Qin N, et al. Dysbiosis signature of mycobiota in colon polyp and colorectal cancer. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2017;36(12):2457-68. doi: 10.1007/s10096-017-3085-6. PubMed PMID: 28821976.
Referans14. Mori G, Rampelli S, Orena BS, Rengucci C, De Maio G, Barbieri G, et al. Shifts of Faecal Microbiota During Sporadic Colorectal Carcinogenesis. Scientific reports. 2018;8(1):10329. doi: 10.1038/s41598-018-28671-9. PubMed PMID: 29985435; PubMed Central PMCID: PMC6037773.
Referans15. Shiotani A, Fukushima S, Matsumoto H. [Carcinogenesis and Gut Microbiota]. Gan to kagaku ryoho Cancer & chemotherapy. 2019;46(2):199-204. PubMed PMID: 30914517.
Referans16. de Waal GM, de Villiers WJS, Forgan T, Roberts T, Pretorius E. Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability. Scientific reports. 2020;10(1):8777. doi: 10.1038/s41598-020-65324-2. PubMed PMID: 32472080; PubMed Central PMCID: PMC7260372.
Referans17. Belayneh YM, Amare GG, Meharie BG. Updates on the molecular mechanisms of aspirin in the prevention of colorectal cancer: Review. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2021:1078155220984846. doi: 10.1177/1078155220984846. PubMed PMID: 33427041.
Referans18. Chang SC, Yang WV. Hyperglycemia, tumorigenesis, and chronic inflammation. Critical reviews in oncology/hematology. 2016;108:146-53. doi: 10.1016/j.critrevonc.2016.11.003. PubMed PMID: 27931833.
Referans19. Dmitrieva-Posocco O, Dzutsev A, Posocco DF, Hou V, Yuan W, Thovarai V, et al. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019;50(1):166-80 e7. doi: 10.1016/j.immuni.2018.11.015. PubMed PMID: 30650375; PubMed Central PMCID: PMC6490968.
Referans20. Murata M. Inflammation and cancer. Environmental health and preventive medicine. 2018;23(1):50. doi: 10.1186/s12199-018-0740-1. PubMed PMID: 30340457; PubMed Central PMCID: PMC6195709.
Referans21. Lee DW, Han SW, Kang JK, Bae JM, Kim HP, Won JK, et al. Association Between Fusobacterium nucleatum, Pathway Mutation, and Patient Prognosis in Colorectal Cancer. Annals of surgical oncology. 2018;25(11):3389-95. doi: 10.1245/s10434-018-6681-5. PubMed PMID: 30062471.
Referans22. Tomkovich S, Yang Y, Winglee K, Gauthier J, Muhlbauer M, Sun X, et al. Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis. Cancer Res. 2017;77(10):2620-32. doi: 10.1158/0008-5472.CAN-16-3472. PubMed PMID: 28416491; PubMed Central PMCID: PMC5468752.
Referans23. Lin C, Cai X, Zhang J, Wang W, Sheng Q, Hua H, et al. Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer. Digestion. 2019;100(1):72-8. doi: 10.1159/000494052. PubMed PMID: 30332668.
Referans24. Butt J, Epplein M. Helicobacter pylori and colorectal cancer-A bacterium going abroad? PLoS pathogens. 2019;15(8):e1007861. doi: 10.1371/journal.ppat.1007861. PubMed PMID: 31393968; PubMed Central PMCID: PMC6687094.
Referans25. Kim TJ, Kim ER, Chang DK, Kim YH, Baek SY, Kim K, et al. Helicobacter pylori infection is an independent risk factor of early and advanced colorectal neoplasm. Helicobacter. 2017;22(3). doi: 10.1111/hel.12377. PubMed PMID: 28124492.
Referans26. Wang M, Kong WJ, Zhang JZ, Lu JJ, Hui WJ, Liu WD, et al. Association of Helicobacter pylori infection with colorectal polyps and malignancy in China. World journal of gastrointestinal oncology. 2020;12(5):582-91. doi: 10.4251/wjgo.v12.i5.582. PubMed PMID: 32461789; PubMed Central PMCID: PMC7235179.
Referans27. Gunawardhana N, Jang S, Choi YH, Hong YA, Jeon YE, Kim A, et al. Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway. Frontiers in cellular and infection microbiology. 2017;7:541. doi: 10.3389/fcimb.2017.00541. PubMed PMID: 29379775; PubMed Central PMCID: PMC5775237.
Referans28. Luan C, Liu Z, Li Y, Dong T. Association among helicobacter pylori infection, gastrin level and colorectal cancer in patients aged 50 years and over. Pakistan journal of medical sciences. 2020;36(5):899-903. doi: 10.12669/pjms.36.5.1993. PubMed PMID: 32704260; PubMed Central PMCID: PMC7372695.
Referans29. Selgrad M, Bornschein J, Kandulski A, Hille C, Weigt J, Roessner A, et al. Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms. International journal of cancer. 2014;135(5):1127-31. doi: 10.1002/ijc.28758. PubMed PMID: 24496701.
Referans30. Papastergiou V, Karatapanis S, Georgopoulos SD. Helicobacter pylori and colorectal neoplasia: Is there a causal link? World J Gastroenterol. 2016;22(2):649-58. doi: 10.3748/wjg.v22.i2.649. PubMed PMID: 26811614; PubMed Central PMCID: PMC4716066.
Referans31. Kumar A, Kim M, Lukin DJ. Helicobacter pylori is associated with increased risk of serrated colonic polyps: Analysis of serrated polyp risk factors. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 2018;37(3):235-42. doi: 10.1007/s12664-018-0855-8. PubMed PMID: 29876742.
Referans32. Abbass K, Gul W, Beck G, Markert R, Akram S. Association of Helicobacter pylori infection with the development of colorectal polyps and colorectal carcinoma. South Med J. 2011;104(7):473-6. doi: 10.1097/SMJ.0b013e31821e9009. PubMed PMID: 21886044.
Referans33. Soylu A, Ozkara S, Alis H, Dolay K, Kalayci M, Yasar N, et al. Immunohistochemical testing for Helicobacter Pylori existence in neoplasms of the colon. BMC Gastroenterol. 2008;8:35. doi: 10.1186/1471-230X-8-35. PubMed PMID: 18702825; PubMed Central PMCID: PMCPMC2527302.
Referans34. İsmail Hakkı KALKAN FS, Sefa GÜLİTER, Pınar ATASOY. The relationship between gastric preneoplastic findings and colon polyps Akademik gastroenteroloji dergisi. 2013;12(3):108-12.
Referans35. Nam JH, Hong CW, Kim BC, Shin A, Ryu KH, Park BJ, et al. Helicobacter pylori infection is an independent risk factor for colonic adenomatous neoplasms. Cancer causes & control : CCC. 2017;28(2):107-15. doi: 10.1007/s10552-016-0839-x. PubMed PMID: 28025763.
Referans36. Yang F, Xu YL, Zhu RF. Helicobacter pylori infection and the risk of colorectal carcinoma: a systematic review and meta-analysis. Minerva medica. 2019;110(5):464-70. doi: 10.23736/S0026-4806.19.05942-1. PubMed PMID: 31368293.
Referans37. Liu IL, Tsai CH, Hsu CH, Hu JM, Chen YC, Tian YF, et al. Helicobacter pylori infection and the risk of colorectal cancer: a nationwide population-based cohort study. QJM : monthly journal of the Association of Physicians. 2019;112(10):787-92. doi: 10.1093/qjmed/hcz157. PubMed PMID: 31250012.
Referans38. Nam SY, Park BJ, Ryu KH, Nam JH. Effect of Helicobacter pylori infection and its eradication on the fate of gastric polyps. Eur J Gastroenterol Hepatol. 2016;28(4):449-54. doi: 10.1097/MEG.0000000000000553. PubMed PMID: 26735158.
Referans39. Wu Q YZ, Xu P, Gao LC, Fan DM. Association between Helicobacter pylori infection and the riskof colorectal neoplasia: a systematic review and meta-analysis . Colorectal Disease 2013;July(7):e352-64.
Referans40. Wang F, Sun MY, Shi SL, Lv ZS. Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies. Colorectal Dis. 2014;16(4):246-52. doi: 10.1111/codi.12290. PubMed PMID: 23692360.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Oktay Bulur ^*
0000-0002-0332-3871
Türkiye

Evrim Kahramanoğlu Aksoy
0000-0001-8887-3428
Türkiye

Gülçin Güler Şimşek
0000-0001-7710-4631
Türkiye

Murat Eser
0000-0002-6687-0899
Türkiye

Zeliha Asiltürk Lülleci
0000-0003-1165-3982
Türkiye

Kürşat Dal
0000-0002-9116-6115
Türkiye

Metin Uzman
0000-0002-5412-8523
Türkiye

Publication Date

December 31, 2021

Submission Date

August 10, 2021

Acceptance Date

December 8, 2021

Published in Issue

Year 2021 Volume: 43 Number: 4

DOI

https://doi.org/10.7197/cmj.980147

IZ

https://izlik.org/JA78DC85KA

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RIS / Bibtex

AMA

1.Bulur O, Aksoy EK, Güler Şimşek G, et al. The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies. CMJ. 2021;43(4):346-354. doi:10.7197/cmj.980147

Öz

The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite