The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies

Oktay Bulur; Evrim Kahramanoğlu Aksoy; Gülçin Güler Şimşek; Murat Eser; Zeliha Asiltürk Lülleci; Kürşat Dal; Metin Uzman

doi:10.7197/cmj.980147

EN

The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies

Öz

Objective: Several factors play role in colorectal carcinogenesis. Among these factors, helicobacter pylori infection is supposed to be one of the causative factors. Previous studies were focused on investigation of the relationship between helicobacter pylori existence and colon carcinomas by particular serological diagnostic tests. The aim of our study was to determine the effect of the helicobacter pylori infection and the severity of inflammation related to this infection on the colon carcinomas and non carcinoma colon mass lesions(tubular adenoma, tubulovillous adenoma, hyperplastic polyp).

Method: A retrospective study was conducted at Kecioren Teaching - Research Hospital between 2010 to 2018. The files of 657 patients who underwent colonoscopy and were diagnosed as colon benign or malign mass lesions were examined retrospectively from the hospital database. Two hundred five patients who had undergone both upper gastrointestinal endoscopy and colonoscopies were included in the study. The presence and severity of inflammation due to helicobacter pylori were evaluated by histopathological examination of biopsies taken during upper gastrointestinal endoscopy. The severity of H. pylori inflammation was graded according to the Sydney classification

Results: In the comparison of colon carcinoma with other colon mass lesions group, there was no statistical significance in terms of gender (P= 0.094) and H. pylori serology (P= 0.998). However, the degree of inflammation was significantly high in patients with colon carcinoma than other colon mass lesions (P< 0.001).

Conclusions: The fact that the severity of helicobacter pylori inflammation is higher in patients with colon carcinoma than patients with non-carcinoma colonic mass lesions suggests that inflammation due to helicobacter pylori may be more important than the presence of helicobacter pylori in the carcinogenesis of colon cancer.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Oktay Bulur ^*
0000-0002-0332-3871
Türkiye

Evrim Kahramanoğlu Aksoy
0000-0001-8887-3428
Türkiye

Gülçin Güler Şimşek
0000-0001-7710-4631
Türkiye

Murat Eser
0000-0002-6687-0899
Türkiye

Zeliha Asiltürk Lülleci
0000-0003-1165-3982
Türkiye

Kürşat Dal
0000-0002-9116-6115
Türkiye

Metin Uzman
0000-0002-5412-8523
Türkiye

Yayımlanma Tarihi

31 Aralık 2021

Gönderilme Tarihi

10 Ağustos 2021

Kabul Tarihi

8 Aralık 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 43 Sayı: 4

DOI

https://doi.org/10.7197/cmj.980147

IZ

https://izlik.org/JA78DC85KA

Kaynak Göster

RIS / Bibtex

APA

Bulur, O., Aksoy, E. K., Güler Şimşek, G., Eser, M., Asiltürk Lülleci, Z., Dal, K., & Uzman, M. (2021). The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies. Cumhuriyet Medical Journal, 43(4), 346-354. https://doi.org/10.7197/cmj.980147

AMA

1.Bulur O, Aksoy EK, Güler Şimşek G, vd. The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies. CMJ. 2021;43(4):346-354. doi:10.7197/cmj.980147

Chicago

Bulur, Oktay, Evrim Kahramanoğlu Aksoy, Gülçin Güler Şimşek, vd. 2021. “The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies”. Cumhuriyet Medical Journal 43 (4): 346-54. https://doi.org/10.7197/cmj.980147.

EndNote

Bulur O, Aksoy EK, Güler Şimşek G, Eser M, Asiltürk Lülleci Z, Dal K, Uzman M (01 Aralık 2021) The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies. Cumhuriyet Medical Journal 43 4 346–354.

IEEE

[1]O. Bulur vd., “The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies”, CMJ, c. 43, sy 4, ss. 346–354, Ara. 2021, doi: 10.7197/cmj.980147.

ISNAD

Bulur, Oktay - Aksoy, Evrim Kahramanoğlu - Güler Şimşek, Gülçin - Eser, Murat - Asiltürk Lülleci, Zeliha - Dal, Kürşat - Uzman, Metin. “The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies”. Cumhuriyet Medical Journal 43/4 (01 Aralık 2021): 346-354. https://doi.org/10.7197/cmj.980147.

JAMA

1.Bulur O, Aksoy EK, Güler Şimşek G, Eser M, Asiltürk Lülleci Z, Dal K, Uzman M. The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies. CMJ. 2021;43:346–354.

MLA

Bulur, Oktay, vd. “The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies”. Cumhuriyet Medical Journal, c. 43, sy 4, Aralık 2021, ss. 346-54, doi:10.7197/cmj.980147.

Vancouver

1.Oktay Bulur, Evrim Kahramanoğlu Aksoy, Gülçin Güler Şimşek, Murat Eser, Zeliha Asiltürk Lülleci, Kürşat Dal, Metin Uzman. The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies. CMJ. 01 Aralık 2021;43(4):346-54. doi:10.7197/cmj.980147