Model Organisms and Systems in Life Sciences

Mert Polat; Feride İffet Şahin; Yunus Kasım Terzi

doi:10.7197/cmj.991430

EN

Model Organisms and Systems in Life Sciences

Abstract

Approximately 6-7% of newborns have congenital anomalies. The causes of these anomalies are genetic-based, environmental, or multifactorial. The cause of almost 50% of congenital anomalies is not fully known. There are many specific birth defects as part of the syndromes. Even though the syndromes are complex, they use common signaling pathways in the developmental process. Because of the complex nature of developmental disorders, different types of model systems are necessary to understand the molecular pathogenesis of diseases. The molecular infrastructure of diseases and problems in a developmental process is revealed with different types of model systems. While studying the development of multicellular organisms, related molecular and cellular processes are examined. While conducting these studies, model organisms, organoids, and computerized (in silico) models are used. Each method has its advantages and disadvantages.
In this review, we will provide recent knowledge on the advantages and disadvantages of modeling systems used to understand developmental processes.

Keywords

Supporting Institution

Bulunmamaktadır

Project Number

Bulunmamaktadır

Thanks

Bulunmamaktadır

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Mert Polat ^*
0000-0002-9555-4932
Türkiye

Feride İffet Şahin
0000-0001-7308-9673
Türkiye

Yunus Kasım Terzi
0000-0001-5612-9696
Türkiye

Publication Date

March 30, 2022

Submission Date

September 29, 2021

Acceptance Date

March 20, 2022

Published in Issue

Year 2022 Volume: 44 Number: 1

DOI

https://doi.org/10.7197/cmj.991430

IZ

https://izlik.org/JA98FT67LB

Cite

RIS / Bibtex

AMA

1.Polat M, Şahin Fİ, Terzi YK. Model Organisms and Systems in Life Sciences. CMJ. 2022;44(1):1-8. doi:10.7197/cmj.991430

Cited By

Beslenme ve Hastalık Modellemelerinde Drosophila melanogaster’in Yeri ve Önemi

Muş Alparslan Üniversitesi Fen Bilimleri Dergisi

https://doi.org/10.18586/msufbd.1580717

Öz

Model Organisms and Systems in Life Sciences

Abstract

Keywords

Supporting Institution

Project Number

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Beslenme ve Hastalık Modellemelerinde Drosophila melanogaster’in Yeri ve Önemi