Model Organisms and Systems in Life Sciences

Mert Polat; Feride İffet Şahin; Yunus Kasım Terzi

doi:10.7197/cmj.991430

EN

Model Organisms and Systems in Life Sciences

Abstract

Approximately 6-7% of newborns have congenital anomalies. The causes of these anomalies are genetic-based, environmental, or multifactorial. The cause of almost 50% of congenital anomalies is not fully known. There are many specific birth defects as part of the syndromes. Even though the syndromes are complex, they use common signaling pathways in the developmental process. Because of the complex nature of developmental disorders, different types of model systems are necessary to understand the molecular pathogenesis of diseases. The molecular infrastructure of diseases and problems in a developmental process is revealed with different types of model systems. While studying the development of multicellular organisms, related molecular and cellular processes are examined. While conducting these studies, model organisms, organoids, and computerized (in silico) models are used. Each method has its advantages and disadvantages.
In this review, we will provide recent knowledge on the advantages and disadvantages of modeling systems used to understand developmental processes.

Keywords

Destekleyen Kurum

Bulunmamaktadır

Proje Numarası

Bulunmamaktadır

Teşekkür

Bulunmamaktadır

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Mert Polat ^*
0000-0002-9555-4932
Türkiye

Feride İffet Şahin
0000-0001-7308-9673
Türkiye

Yunus Kasım Terzi
0000-0001-5612-9696
Türkiye

Yayımlanma Tarihi

30 Mart 2022

Gönderilme Tarihi

29 Eylül 2021

Kabul Tarihi

20 Mart 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 44 Sayı: 1

DOI

https://doi.org/10.7197/cmj.991430

IZ

https://izlik.org/JA98FT67LB

Kaynak Göster

RIS / Bibtex

AMA

1.Polat M, Şahin Fİ, Terzi YK. Model Organisms and Systems in Life Sciences. CMJ. 2022;44(1):1-8. doi:10.7197/cmj.991430

Cited By

Beslenme ve Hastalık Modellemelerinde Drosophila melanogaster’in Yeri ve Önemi

Muş Alparslan Üniversitesi Fen Bilimleri Dergisi

https://doi.org/10.18586/msufbd.1580717

Öz

Model Organisms and Systems in Life Sciences

Abstract

Keywords

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Beslenme ve Hastalık Modellemelerinde Drosophila melanogaster’in Yeri ve Önemi