Research Article
Evaluation of Nebivolol Therapy in Patients with Heart Failure on Exercise Tissue Doppler Echocardiographic Parameters
Abstract
Objective: Heart failure is one of the most important disease which threats population’s health. Its prevalance increases both in our country and in the world in years. Nebivolol is a molecule which is proved its efficacy in the treatment of heart failure. The aim of this study was to evaluate the changes in echocardiographic parameters such as tissue doppler imaging and myocardial performance index (MPI) after 6 months of nebivolol treatment in patients with heart failure.
Method: 20 patients with heart failure were enrolled to the study The average age was 59.8 ± 8.4 years (15 men, 5 women). During rest and exercise (cycle ergometer) we recorded conventional and tissue doppler parameters. In the first examination we recorded basal measurements. Then nebivolol treatment was administered. After 6 months nebivolol treatment we measured again same echocardiographic parameters.
Results: The average Ejection fraction (EF) of patients with heart failure in this study was %38.85 ± 6.45 in the first examination. The average EF was increased to %40.95 ± 5.47 in the end of the study (p<0.05). After 6 months nebivolol treatment both during rest and exercise we found significant improvements in the tissue doppler parameters and MPI.
Conclusions: Nebivolol is associated with significant improvements in EF in the patients with heart failure. In addition, both during rest and exercise, it’s associated with improvements in tissue doppler parameters which can show beneficial effect on the prognosis of this group of patients.
References
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Year 2022,
, 31 - 37, 30.03.2022
Abstract
References
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- 2. The Merit HF study group. Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomized intervention trail in congestive heart failure. Lancet 1999;353:9–13.
- 3. Shibata MC, Flather MD, Bohm M, Borbola J, Cohen-Solal A, Dumitrascu D,et al. Study of the effect of nebivolol intervention on outcomes and rehospitalisation in seniors with heart failure. Rationale and design. Inter J Cardiol 2002;86:77–85.
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- 11. Wang M, Yip G, Wang AY, zhang Y, Ho PY, Tse MK, et al. Peak early distolic mitral annulus velocity by tissue doppler imaging adds independent and incremental prognostic value. J Am Coll Cardiol 2003;41:820-6.
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- 21. Yamamoto T, Oki T, Yamada H, Tanaka H, Ishimoto T, Wakatsuki T, et al. Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction. J Am Soc Echocardiogr 2003;16:333-9.
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- 23. Düzenli MA, Özdemir K, Aygül N, Zengin K, Gök H. Kalp yetersizliği olan hastalarda fonksiyonel kapasitenin değerlendirilmesinde doku doppler ekokardiografinin yeri. Arch Turk Soc Cardiol 2008;36:143-9.
- 24. Tei C, Nishimura RA, Seward JB, Tajik AJ. Noninvasive Doppler-derived myocardial performance index: correlation with simultaneous measurements of cardiac catheterization measurements. J Am Soc Echocardiogr 1997;10:169–78.
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- 28. Dujardin KS, Tei C, Yeo TC, Hodge DO, Rossi A, Seward JB. Prognostic value of a Doppler index combining systolic and diastolic performance in idiopathic-dilated cardiomyopathy. Am J Cardiol 1998;82:1071–6.
- 29. Bruch C, Schmermund A, Marin D, Katz M, Bartel T, Schaar J, Erbel R. Tei-index in patients with mild-to-moderate congestive heart failure. Eur Heart J 2000;21:1888–95.
- 30. Downes TR, Nomeir AM, Stewart K, Mumma M, Kerensky R, Little WC. Effect of alternation in loading conditions on both normal and abnormal patterns of left ventricular filling in healthy individuals. Am J Cardiol 1990;65:377–82.
- 31. Hurrell DG, Nishimura RA, Ilstrup DM, Appleton CP.Utility of preload alternation in assessment of left ventricularfi lling pressure by Doppler echocardiography: a simultaneouscatheterization and Doppler echocardiographic study. J Am Coll Cardiol 1997;30:459–67.
- 32. Sasao H, Noda R, Hasegawa T, Endo A, Oimatsu H, Takada T. Prognostic value of the Tei index combining systolic and diastolic myocardial performance in patients with acute myocardial infarction treated by successful primary angioplasty. Heart Vessels 2004;19:68–74.
- 33. Arnlov J, Lind L, Andren B, Riserus U, Berglund L, Lithell H. A Doppler-derived index of combined left ventricular systolic and diastolic function is an independent predictor of cardiovascular mortality in elderly men. Am Heart J 2005;149:902–7.
- 34. Gaulito L, Ignone G, DeMaria AN. Contraction and relaxation velocities of the normal left ventricle using pulsed-wave tissue Doppler echocardiography. Am J Cardiol 1998;81:609–14.
There are 34 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | March 30, 2022 |
| Acceptance Date | March 20, 2022 |
| Published in Issue | Year 2022 |