EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS

Arzuhan Çetindağ Çiltaş; Ayşegül Öztürk

doi:10.7197/cmj.1153681

Research Article

Year 2023, , 25 - 34, 31.03.2023

Arzuhan Çetindağ Çiltaş , Ayşegül Öztürk

https://doi.org/10.7197/cmj.1153681

Abstract

References

1. Ozdemir E, Bagcivan I, Gursoy S. Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats. Bosn J Basic Med Sci. 2013;13(2):119. doi:10.17305/BJBMS.2013.2394
2. Ozdemir E. The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance. International Journal of Basic & Clinical Pharmacology. 2017;6(2). doi:10.18203/2319-2003.ijbcp20170312
3. Eidson L, Anne Z.M. Persistent peripheral inflammation attenuates morphine-induced periaqueductal gray glial cell activation and analgesic tolerance in the male rat. The Journal of Pain.2021; 14(4): 393-404.
4. Ferrini F, Trang T, Mattioli T, et al. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis. Nature Neuroscience. 2013;16(2):183-92.
5. Cui Y, Liao X, Liu W, et al. A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav Immun. 2008;22(1):114-23.
6. Watkins LR, Maier SF. The pain of being sick: Implications of immune-to-brain communication for understanding pain. Annu Rev Psychol. 2000;51:29-57. doi:10.1146/ANNUREV.PSYCH.51.1.29
7. Wen Y, Tan P, Cheng J, Liu Y, Formosan RJ-J of the, 2011 undefined. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc. 2011;110(8):487-94
8. Han Y, Jiang C, Tang J, et al. Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain. 2014;18(10):1458-1470.
9. Hutchinson M, Shavit Y, Grace P, et al. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev. 2011;63(3):772-810.
10. Gustin A, Kirchmeyer M, Koncina E, et al. NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. PLoS One. 2015;10(6). doi:10.1371/JOURNAL.PONE.0130624
11. Sun J, Liu S, Mata M, Fink DJ, Hao S. Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats. Gene Ther. 2012;19(1):101-108.
12. Patel K, Bhaskaran M, Dani D, et al. Role of Heme Oxygenase–1 in Morphine-Modulated Apoptosis and Migration of Macrophages. J Infect Dis. 2003;187(1):47-54.
13. Singhal P, Pamarthi M, Shah R, et al. Morphine stimulates superoxide formation by glomerular mesangial cells. Inflammation. 1994;18(3):293-299.
14. Mao J, Sung B, Ji RR, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci. 2002;22(17):7650-7661. doi:10.1523/JNEUROSCI.22-17-07650.2002
15. Kerns JC, Arundel C, Chawla LS. Thiamin Deficiency in People with Obesity. Adv Nutr. 2015;6(2):147-153. doi:10.3945/AN.114.007526
16. Sechi G, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007;6(5):442-455.
17. Jhala SS, Hazell AS. Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism. Neurochem Int. 2011;58(3):248-260.
18. Avcı O, Taşkıran AŞ . Turkish Journal of Medical Sciences Anakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats. Turk J Med Sci. 2020;50(8):2048-2058.
19. Kruger NJ. The Bradford Method For Protein Quantitation. Published online 2009:17-24. doi:10.1007/978-1-59745-198-7_4
20. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37(2):112-119
21. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111 22. Altun A, Yildirim K, Ozdemir E, Bagcivan I, Gursoy S, Durmus N. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. J Physiol Sci 2015 655. 2015;65(5):407-415. doi:10.1007/S12576-015-0379-2
23. Ozdemir E, Gursoy S, Bagcivan I. The effects of serotonin/norepinephrine reuptake inhibitors and serotonin receptor agonist on morphine analgesia and tolerance in rats. J Physiol Sci 2012 624. 2012;62(4):317-323. doi:10.1007/S12576-012-0207-X
24. Dumas EO, Pollack GM. Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective. AAPS J 2008 104. 2008;10(4):537-551. doi:10.1208/S12248-008-9056-1
25. Baser T, Ozdemir E, Filiz AK, Taskiran AS, Gursoy S. Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats. Can J Physiol Pharmacol. 2021;99(5):461-467.
26. Sumathi T, Nathiya VC, Sakthikumar M. Protective Effect of Bacoside-A against Morphine-Induced Oxidative Stress in Rats. Indian J Pharm Sci. 2011;73(4):409. doi:10.4103/0250-474X.95624
27. Zhang YT, Zheng QS, Pan J, Zheng RL. Oxidative damage of biomolecules in mouse liver induced by morphine and protected by antioxidants. Basic Clin Pharmacol Toxicol. 2004;95(2):53-58. doi:10.1111/J.1742-7843.2004.950202.X
28. Kuthati Y, Busa P, Tummala S, et al. Mesoporous polydopamine nanoparticles attenuate morphine tolerance in neuropathic pain rats by inhibition of oxidative stress and restoration of the endogenous antioxidant system. Antioxidants. 2021;10(2):1-21. doi:10.3390/ANTIOX10020195
29. Pérez-Casanova A, Husain K, Noel RJ Jr, Rivera-Amill V, Kumar A. Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque. Mol Cell Biochem. 2008;308(1-2):169-175. doi:10.1007/S11010-007-9625-0
30. Skrabalova J, Drastichova Z, Novotny J. Morphine as a Potential Oxidative Stress-Causing Agent. Mini Rev Org Chem. 2013;10(4):367-372. doi:10.2174/1570193X113106660031
31. Braga A V, Costa SOAM, Rodrigues FF, et al. Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels. Inflammopharmacology 2019 281. 2019;28(1):201-213. doi:10.1007/S10787-019-00625-1
32. França DS, Souza ALS, Almeida KR, Dolabella SS, Martinelli C, Coelho MM. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001;421(3):157-164. doi:10.1016/S0014-2999(01)01038-X
33. Reyes-García G, Medina-Santillán R, Terán-Rosales F, Mateos-García E, Castillo-Henkel C. Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat. J Pharmacol Toxicol Methods. 1999;42(2):73-77. doi:10.1016/S1056-8719(00)00045-9
34. Kodama K, Suzuki M, Toyosawa T, Araki S. Inhibitory mechanisms of highly purified vitamin B2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice. Life Sci. 2005;78(2):134-139.
35. Sweitzer SM, Schubert P, DeLeo JA. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther. 2001;297(3):1210-1217.
36. Wang X, Loram LC, Ramos K, et al. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A. 2012;109(16):6325-6330.
37. Raghavendra V, Rutkowski MD, DeLeo JA. The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J Neurosci. 2002;22(22):9980-9989.
38. Bhat RS, Bhaskaran M, Mongia A, Hitosugi N, Singhal PC. Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation. J Leukoc Biol. 2004;75(6):1131-1138. doi:10.1189/JLB.1203639
39. Mao J, Sung B, Ji RR, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci. 2002;22(17):7650-7661.
40. Hu S, Sheng WS, Lokensgard JR, Peterson PK. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. 2002;42(6):829-836. doi:10.1016/S0028-3908(02)00030-8
41. Taskiran AS, Avci O. Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect. Neurosci Lett. 2021;741. doi:10.1016/J.NEULET.2020.135504
42. Osmanlıoğlu HÖ, Yıldırım MK, Akyuva Y, Yıldızhan K, Nazıroğlu M. Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus. Mol Neurobiol 2020 578. 2020;57(8):3376-3389.

EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS

Year 2023, , 25 - 34, 31.03.2023

Arzuhan Çetindağ Çiltaş , Ayşegül Öztürk

https://doi.org/10.7197/cmj.1153681

Abstract

Absract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development. This search goals to examine the possible role of thiamine use on oxidative stress, inflammation and apoptosis in the development of morphine analgesia and morphine tolerance in rats.
Methods: Thirty-six male Wistar rats were used in this study. The rats were severed into six groups: saline, 100 mg/kg thiamine, 5 mg/kg morphine, thiamine + morphine, morphine tolerance and thiamine + morphine tolerance. The resulting analgesic effect was measured by hot plate and tail movement analgesia tests. TAS and TOS, inflammation parameters, and apoptosis protein levels of the dorsal root ganglion tissues sample were measured using an ELISA kit.
Results: When thiamine was given alone, it did not show anti-nociceptive effect (p>0.05). In addition, thiamine enhanced the analgesic effect of morphine (p < 0.05) and also significantly reduced tolerance to morphine (p < 0.05). However, it reduced TOS when administered with a single dose of morphine and tolerance induction (p < 0.05). In addition, thiamine reduced apoptosis protein levels after tolerance development (p < 0.05).
Conclusion: Consequently, these results may attain by reducing TOS, inflammation, and apoptosis.

Keywords

Tiamine, Morphine Analgesia, Morphine Tolerance, Total Antioxidant Status, Total Oxidant Status, Apoptosis, İnflammation

References

1. Ozdemir E, Bagcivan I, Gursoy S. Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats. Bosn J Basic Med Sci. 2013;13(2):119. doi:10.17305/BJBMS.2013.2394
2. Ozdemir E. The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance. International Journal of Basic & Clinical Pharmacology. 2017;6(2). doi:10.18203/2319-2003.ijbcp20170312
3. Eidson L, Anne Z.M. Persistent peripheral inflammation attenuates morphine-induced periaqueductal gray glial cell activation and analgesic tolerance in the male rat. The Journal of Pain.2021; 14(4): 393-404.
4. Ferrini F, Trang T, Mattioli T, et al. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis. Nature Neuroscience. 2013;16(2):183-92.
5. Cui Y, Liao X, Liu W, et al. A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav Immun. 2008;22(1):114-23.
6. Watkins LR, Maier SF. The pain of being sick: Implications of immune-to-brain communication for understanding pain. Annu Rev Psychol. 2000;51:29-57. doi:10.1146/ANNUREV.PSYCH.51.1.29
7. Wen Y, Tan P, Cheng J, Liu Y, Formosan RJ-J of the, 2011 undefined. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc. 2011;110(8):487-94
8. Han Y, Jiang C, Tang J, et al. Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain. 2014;18(10):1458-1470.
9. Hutchinson M, Shavit Y, Grace P, et al. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev. 2011;63(3):772-810.
10. Gustin A, Kirchmeyer M, Koncina E, et al. NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. PLoS One. 2015;10(6). doi:10.1371/JOURNAL.PONE.0130624
11. Sun J, Liu S, Mata M, Fink DJ, Hao S. Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats. Gene Ther. 2012;19(1):101-108.
12. Patel K, Bhaskaran M, Dani D, et al. Role of Heme Oxygenase–1 in Morphine-Modulated Apoptosis and Migration of Macrophages. J Infect Dis. 2003;187(1):47-54.
13. Singhal P, Pamarthi M, Shah R, et al. Morphine stimulates superoxide formation by glomerular mesangial cells. Inflammation. 1994;18(3):293-299.
14. Mao J, Sung B, Ji RR, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci. 2002;22(17):7650-7661. doi:10.1523/JNEUROSCI.22-17-07650.2002
15. Kerns JC, Arundel C, Chawla LS. Thiamin Deficiency in People with Obesity. Adv Nutr. 2015;6(2):147-153. doi:10.3945/AN.114.007526
16. Sechi G, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007;6(5):442-455.
17. Jhala SS, Hazell AS. Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism. Neurochem Int. 2011;58(3):248-260.
18. Avcı O, Taşkıran AŞ . Turkish Journal of Medical Sciences Anakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats. Turk J Med Sci. 2020;50(8):2048-2058.
19. Kruger NJ. The Bradford Method For Protein Quantitation. Published online 2009:17-24. doi:10.1007/978-1-59745-198-7_4
20. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37(2):112-119
21. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111 22. Altun A, Yildirim K, Ozdemir E, Bagcivan I, Gursoy S, Durmus N. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. J Physiol Sci 2015 655. 2015;65(5):407-415. doi:10.1007/S12576-015-0379-2
23. Ozdemir E, Gursoy S, Bagcivan I. The effects of serotonin/norepinephrine reuptake inhibitors and serotonin receptor agonist on morphine analgesia and tolerance in rats. J Physiol Sci 2012 624. 2012;62(4):317-323. doi:10.1007/S12576-012-0207-X
24. Dumas EO, Pollack GM. Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective. AAPS J 2008 104. 2008;10(4):537-551. doi:10.1208/S12248-008-9056-1
25. Baser T, Ozdemir E, Filiz AK, Taskiran AS, Gursoy S. Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats. Can J Physiol Pharmacol. 2021;99(5):461-467.
26. Sumathi T, Nathiya VC, Sakthikumar M. Protective Effect of Bacoside-A against Morphine-Induced Oxidative Stress in Rats. Indian J Pharm Sci. 2011;73(4):409. doi:10.4103/0250-474X.95624
27. Zhang YT, Zheng QS, Pan J, Zheng RL. Oxidative damage of biomolecules in mouse liver induced by morphine and protected by antioxidants. Basic Clin Pharmacol Toxicol. 2004;95(2):53-58. doi:10.1111/J.1742-7843.2004.950202.X
28. Kuthati Y, Busa P, Tummala S, et al. Mesoporous polydopamine nanoparticles attenuate morphine tolerance in neuropathic pain rats by inhibition of oxidative stress and restoration of the endogenous antioxidant system. Antioxidants. 2021;10(2):1-21. doi:10.3390/ANTIOX10020195
29. Pérez-Casanova A, Husain K, Noel RJ Jr, Rivera-Amill V, Kumar A. Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque. Mol Cell Biochem. 2008;308(1-2):169-175. doi:10.1007/S11010-007-9625-0
30. Skrabalova J, Drastichova Z, Novotny J. Morphine as a Potential Oxidative Stress-Causing Agent. Mini Rev Org Chem. 2013;10(4):367-372. doi:10.2174/1570193X113106660031
31. Braga A V, Costa SOAM, Rodrigues FF, et al. Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels. Inflammopharmacology 2019 281. 2019;28(1):201-213. doi:10.1007/S10787-019-00625-1
32. França DS, Souza ALS, Almeida KR, Dolabella SS, Martinelli C, Coelho MM. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001;421(3):157-164. doi:10.1016/S0014-2999(01)01038-X
33. Reyes-García G, Medina-Santillán R, Terán-Rosales F, Mateos-García E, Castillo-Henkel C. Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat. J Pharmacol Toxicol Methods. 1999;42(2):73-77. doi:10.1016/S1056-8719(00)00045-9
34. Kodama K, Suzuki M, Toyosawa T, Araki S. Inhibitory mechanisms of highly purified vitamin B2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice. Life Sci. 2005;78(2):134-139.
35. Sweitzer SM, Schubert P, DeLeo JA. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther. 2001;297(3):1210-1217.
36. Wang X, Loram LC, Ramos K, et al. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A. 2012;109(16):6325-6330.
37. Raghavendra V, Rutkowski MD, DeLeo JA. The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J Neurosci. 2002;22(22):9980-9989.
38. Bhat RS, Bhaskaran M, Mongia A, Hitosugi N, Singhal PC. Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation. J Leukoc Biol. 2004;75(6):1131-1138. doi:10.1189/JLB.1203639
39. Mao J, Sung B, Ji RR, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci. 2002;22(17):7650-7661.
40. Hu S, Sheng WS, Lokensgard JR, Peterson PK. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. 2002;42(6):829-836. doi:10.1016/S0028-3908(02)00030-8
41. Taskiran AS, Avci O. Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect. Neurosci Lett. 2021;741. doi:10.1016/J.NEULET.2020.135504
42. Osmanlıoğlu HÖ, Yıldırım MK, Akyuva Y, Yıldızhan K, Nazıroğlu M. Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus. Mol Neurobiol 2020 578. 2020;57(8):3376-3389.

There are 41 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Basic Science Research Articles
Authors	Arzuhan Çetindağ Çiltaş 0000-0002-5420-3546 Ayşegül Öztürk 0000-0001-8130-7968
Publication Date	March 31, 2023
Acceptance Date	March 26, 2023
Published in Issue	Year 2023

Cite

AMA	Çetindağ Çiltaş A, Öztürk A. EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS. CMJ. March 2023;45(1):25-34. doi:10.7197/cmj.1153681

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