Research Article
Year 2022,
, 362 - 369, 31.12.2022
Abstract
References
- 1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382:727-733.
- 2. Golob JL, Lugogo N, Lauring AS, Lok AS. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight. 2021.
- 3. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25.
- 4. Arevalo-Rodriguez I, Buitrago-Garcia D, Simancas-Racines D, et al. False-negative results of initial RT-PCR assays for COVID-19: A systematic review. PLoS One. 2020;15:e0242958.
- 5. Green DA, Zucker J, Westblade LF, et al. Clinical Performance of SARS-CoV-2 Molecular Tests. J Clin Microbiol. 2020;58.
- 6. Kanji JN, Zelyas N, MacDonald C, et al. False negative rate of COVID-19 PCR testing: a discordant testing analysis. Virol J. 2021;18:13.
- 7. Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30:4381-4389.
- 8. Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology. 2020;296:E115-E117.
- 9. Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020;296:E32-E40.
- 10. Khatami F, Saatchi M, Zadeh SST, et al. A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis. Sci Rep. 2020;10:22402.
- 11. Islam N, Salameh JP, Leeflang MM, et al. Thoracic imaging tests for the diagnosis of COVID-19. Cochrane Database Syst Rev. 2020;11:CD013639.
- 12. Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35:219-227.
- 13. Kanne JP, Bai H, Bernheim A, et al. COVID-19 Imaging: What We Know Now and What Remains Unknown. Radiology. 2021:204522.
- 14. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672-675.
- 15. Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J. Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure. Ann Intern Med. 2020;173:262-267.
- 16. Zhang Z, Bi Q, Fang S, et al. Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study. Lancet Microbe. 2021;2:e79-e87.
- 17. Kwee TC, Kwee RM. Chest CT in COVID-19: What the Radiologist Needs to Know. Radiographics. 2020;40:1848-1865.
- 18. Ravikanth R. Diagnostic accuracy and false-positive rate of chest CT as compared to RT-PCR in coronavirus disease 2019 (COVID-19) pneumonia: A prospective cohort of 612 cases from India and review of literature. Indian J Radiol Imaging. 2021;31:S161-S169.
- 19. Waller JV, Kaur P, Tucker A, et al. Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. AJR Am J Roentgenol. 2020;215:834-838.
- 20. Elmokadem AH, Batouty NM, Bayoumi D, et al. Mimickers of novel coronavirus disease 2019 (COVID-19) on chest CT: spectrum of CT and clinical features. Insights Imaging. 2021;12:12.
Year 2022,
, 362 - 369, 31.12.2022
Abstract
Background/aim: Early in the COVID-19 pandemic, chest computerized tomography (CCT) was shown to be more sensitive than real-time reverse transcription polymerase chain Reaction (rRT-PCR) in detecting the disease, especially in regions with high disease prevalence. In this study, we aimed to determine the sensitivity and specificity of chest CT in the diagnosis of COVID-19.
Materials and Methods: Between 17 March, 2020 and 25 April, 2020, 2170 patients who were admitted to the hospital for any reason and underwent chest CT scanning were retrospectively analyzed. Patients with a pre-diagnosis of COVID-19 and a positive rRT-PCR test, two consecutive negative rRT-PCR tests, or with a first negative rRT-PCR test and a positive follow-up rRT-PCR test were included. The day of the rRT-PCR test for these patients was counted as day “0,” and 200 patients whose CCT was performed within +/- three days were included in the study.
Results: Of the 200 patients included in the study, 118 were rRT-PCR-positive, and 82 were rRT-PCR-negative. Of the 118 patients with positive rRT-PCR results, 62/118 (52.5%) had positive CCT scans. With the rRT-PCR results as the reference, the sensitivity, specificity, and accuracy of CCT in indicating COVID-19 infection were 52.5% (95% CI 43–61%), 67% (95% CI 56–77%), and 58.5% (95% CI 51-65%), respectively. The negative predictive value of CCT in diagnosing COVID-19 was greater for women than for men (p = 0.01).
Conclusions: In regions where the prevalence of COVID-19 is not high, the use of CCT in the diagnosis of the disease is not an alternative to the rRT-PCR test due to its low sensitivity.
References
- 1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382:727-733.
- 2. Golob JL, Lugogo N, Lauring AS, Lok AS. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight. 2021.
- 3. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25.
- 4. Arevalo-Rodriguez I, Buitrago-Garcia D, Simancas-Racines D, et al. False-negative results of initial RT-PCR assays for COVID-19: A systematic review. PLoS One. 2020;15:e0242958.
- 5. Green DA, Zucker J, Westblade LF, et al. Clinical Performance of SARS-CoV-2 Molecular Tests. J Clin Microbiol. 2020;58.
- 6. Kanji JN, Zelyas N, MacDonald C, et al. False negative rate of COVID-19 PCR testing: a discordant testing analysis. Virol J. 2021;18:13.
- 7. Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30:4381-4389.
- 8. Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology. 2020;296:E115-E117.
- 9. Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020;296:E32-E40.
- 10. Khatami F, Saatchi M, Zadeh SST, et al. A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis. Sci Rep. 2020;10:22402.
- 11. Islam N, Salameh JP, Leeflang MM, et al. Thoracic imaging tests for the diagnosis of COVID-19. Cochrane Database Syst Rev. 2020;11:CD013639.
- 12. Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35:219-227.
- 13. Kanne JP, Bai H, Bernheim A, et al. COVID-19 Imaging: What We Know Now and What Remains Unknown. Radiology. 2021:204522.
- 14. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672-675.
- 15. Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J. Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure. Ann Intern Med. 2020;173:262-267.
- 16. Zhang Z, Bi Q, Fang S, et al. Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study. Lancet Microbe. 2021;2:e79-e87.
- 17. Kwee TC, Kwee RM. Chest CT in COVID-19: What the Radiologist Needs to Know. Radiographics. 2020;40:1848-1865.
- 18. Ravikanth R. Diagnostic accuracy and false-positive rate of chest CT as compared to RT-PCR in coronavirus disease 2019 (COVID-19) pneumonia: A prospective cohort of 612 cases from India and review of literature. Indian J Radiol Imaging. 2021;31:S161-S169.
- 19. Waller JV, Kaur P, Tucker A, et al. Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. AJR Am J Roentgenol. 2020;215:834-838.
- 20. Elmokadem AH, Batouty NM, Bayoumi D, et al. Mimickers of novel coronavirus disease 2019 (COVID-19) on chest CT: spectrum of CT and clinical features. Insights Imaging. 2021;12:12.
There are 20 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | December 31, 2022 |
| Acceptance Date | December 21, 2022 |
| Published in Issue | Year 2022 |