Research Article
Year 2017,
, 602 - 607, 19.09.2017
Abstract
Amaç: Geçtiğimiz
birkaç dekat boyunca çok sayıda çalışma ile O dışı (A, B, AB) kan grubuna sahip
hastalarda artmış protrombotik eğilim olduğu ortaya konmuştur.Ek olarak birçok
trombotik hastalıkla kan grubu arasında yakın ilişki gösterilmiştir. Ancak kan
gruplarının serebral venöz sinüs trombozu(SVST) gelişimindeki yeri
bilinmemektedir.
Yöntem: Çalışmamıza
retrospektif olarak 01/01/2008- 30/09/2016 tarihleri arasında Cumhuriyet
Üniversitesi Hastanesi Nöroloji Ana Bilim Dalı’na başvuran ve SVST tanısı
kesinleşmiş 41 hasta ile benzer yaş ve cinsiyete sahip 50 kontrol dahil
edildi.Hasta grubu ve kontrol grubu kan grubu dağılımı açısından kıyaslandı.
Bunun yanında hasta grubu kendi içinde beyin parankimal lezyonu olan ve
olmayanlar olarak ikiye ayrılarak kan grubunun prognoz üzerindeki etkisi de
değerlendirildi.
Bulgular: Kontrol grubundaki kan grubu dağılımı Türk
toplumunun genel dağılımını yansıtırken, hasta grubunda O dışı kan grubu oranı
kontrol grubundan daha yüksekti (%34,%19,5), ancak her iki grup arasındaki bu fark
istatistiksel olarak anlamlı değildi. Benzer şekilde hasta grubundaki parankimal
lezyonu olan ve olmayan hastalar arasında da kan grubu dağılımı açısından istatistiksel
açıdan anlamlı fark yoktu.Yapılan lojistik regresyon analizinde de kan grubu
SVST gelişiminde bağımsız bir değişken olarak saptanmadı.
Sonuç: Sonuç
olarak, O dışı kan grubu yüzdesi SVST’li hastalarda sağlıklı kontrollerden daha
yüksektir, ancak bu durum istatistiksel olarak anlamlı değildir. İleride bu
konu ile ilgili daha fazla prospektif ve geniş hasta grubuna sahip çalışmaya
ihtiyaç vardır.
References
- 1. Masuhr F, Mehraein S, Einhaupl K. Cerebral venous and sinüs thrombosis. J Neurol 2004; 251: 11-23.
- 2. Ehtisham A, Stern BJ. Cerebral venous thrombosis: a review. Neurologist 2006; 12: 32-8.
- 3. Zubkov AY, McBane RD, Brown RD, Rabinstein AA. Brain lesions in cerebral venous sinüs thrombosis. Stroke 2009; 40(4): 1509-1511.
- 4. Matsui T, Fujimura Y, Nishida S, Titani K. Human plasma alpha 2-macroglobulin and vonWillebrand factor possess covalently linked ABO (H) blood group antigens in subjects with corresponding ABO phenotype. Blood 1993; 69: 1691-5.
- 5. Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischemic heart disease in British men. BMJ 1990; 300: 1679-82.
- 6. Cronenwett JL, DavisJr JT, Garrett HE. ABO groupsand serum lipids in female atherosclerosis. J CardiovascSurg 1983; 24: 658-61.
- 7. Garrison RJ, Havlisk RJ, Harris RB, Feinleib M, Kannel WB, Padgett SJ. ABO blood group and cardiovascular disease: the Framingham study. Atherosclerosis1976; 25: 311-8.
- 8. Platt D, Muhlberg W, Kiehl L, Schmitt-Ruth R. ABO blood group system, age, sex, risk factors and cardiac infarction. Arch Gerontol Geriatr1985; 4: 241-9.
- 9. Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ. Factor VIII, ABO blood group and the incidence of ischaemic heart disease. Br J Haematol1994; 88: 601-7.
- 10. Thompson SG, Kienast J, Pyke SDM, Haverkate F, van de Loo JCW. Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. N Engl J Med 1995; 332: 635-41.
- 11. Allan TM. ABO blood groups and age groups in surgical venous thromboembolism. Atherosclerosis 1976; 23: 141-2.
- 12. Jick H, Porter J. Thrombophlebitis of the lower extremities and ABO blood type. Arch Intern Med 1978; 138: 1566-7.
- 13. Gonzalez Ordonez AJ, Medina Rodriguez JM, Martin L, Alvarez V, Coto E. The O blood group protects against venous thromboembolismin individuals with the factor V Leiden but not the prothrombin (factor II G20210A) mutation. Blood Coagul Fibrinolysis 1999; 10: 303-7.
- 14. Yang N, Zhang B, Xie L, et al. The association baseline NIH Stroke Scales core with ABO bloodsubtypes in young patients withacute ischemicstroke. Atherosclerosis 2014; 236: 144-9.
- 15. Sabino AP, Ribeiro DD, Domingheti CP. ABO blood group polymorphisms and risk for ischemic stroke and peripheral arterial disease. Mol Biol Rep 2014; 41: 1771-7.
- 16. Akın G, Dostbil N. Türkiye’de Kan Grubu Araştırmaları. Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 2005; 45:1-15.
- 17. Lo´pez JA, Chen J. Pathophysiology of venous thrombosis. Thromb Res 2009; 123 (suppl 4): 30-4.
- 18. Bernardo A, Ball C, Nolasco L, Choi H, Moake JL, Dong JF. Platelet s adhered to endothelial cell-bound ultra-large vonWillebrand factor strings support leukocyte tethering and Rolling under high shear stress. J Thromb Haemost 2005; 3: 562-70.
- 19. Wick TM, Moake JL, Udden MM, Eskin SG, Sears DA, McIntire LV. Unusually large vonWillebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. J Clin Invest 1987; 80: 905-10.
- 20. WuO,Bayoumı N, VıckersMa, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost 2008; 6: 62-9.
Year 2017,
, 602 - 607, 19.09.2017
Abstract
Objective: Several studies in the last few decades demonstrated that patients with non-O blood groups (A, B, AB) have increased prothrombic tendency. In addition, many thrombotic disorders have been shown to be closely related to the blood group. However, the role of blood types in cerebral venous sinus thrombosis (CVST) development is unknown.
Method: Our study included 41 patients who visited the Neurology Department at Cumhuriyet University Hospital and who were diagnosed with CVST between the dates 01/01/2008 and 30/09/ 2016, together with 50 age- and sex-matched controls.The patient and control groups were compared in terms of blood group distribution. In addition, the patient group was divided into two groups according to whether they had parenchymal brain lesions or not, and the effect of the blood group on the prognosis was also assessed.
Results: While the blood group distribution in the control group reflected the overall distribution of the Turkish population, the proportion of the non-O blood group in the patient group was higher than in the control group, however the difference between the two groups was not statistically significant. Similarly, there was no statistically significant difference in blood group distribution between patients with and without parenchymal lesions in the patient group. Logistic regression analysis showed that the blood group was not an independent variable in the development of CVST.
Conclusions:
As a result, the percentage
of non-O blood group was higher in patients with CVST than healthy controls;
however this is not statistically significant. There is a need for more
prospective and extensive future studies on this issue.
References
- 1. Masuhr F, Mehraein S, Einhaupl K. Cerebral venous and sinüs thrombosis. J Neurol 2004; 251: 11-23.
- 2. Ehtisham A, Stern BJ. Cerebral venous thrombosis: a review. Neurologist 2006; 12: 32-8.
- 3. Zubkov AY, McBane RD, Brown RD, Rabinstein AA. Brain lesions in cerebral venous sinüs thrombosis. Stroke 2009; 40(4): 1509-1511.
- 4. Matsui T, Fujimura Y, Nishida S, Titani K. Human plasma alpha 2-macroglobulin and vonWillebrand factor possess covalently linked ABO (H) blood group antigens in subjects with corresponding ABO phenotype. Blood 1993; 69: 1691-5.
- 5. Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischemic heart disease in British men. BMJ 1990; 300: 1679-82.
- 6. Cronenwett JL, DavisJr JT, Garrett HE. ABO groupsand serum lipids in female atherosclerosis. J CardiovascSurg 1983; 24: 658-61.
- 7. Garrison RJ, Havlisk RJ, Harris RB, Feinleib M, Kannel WB, Padgett SJ. ABO blood group and cardiovascular disease: the Framingham study. Atherosclerosis1976; 25: 311-8.
- 8. Platt D, Muhlberg W, Kiehl L, Schmitt-Ruth R. ABO blood group system, age, sex, risk factors and cardiac infarction. Arch Gerontol Geriatr1985; 4: 241-9.
- 9. Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ. Factor VIII, ABO blood group and the incidence of ischaemic heart disease. Br J Haematol1994; 88: 601-7.
- 10. Thompson SG, Kienast J, Pyke SDM, Haverkate F, van de Loo JCW. Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. N Engl J Med 1995; 332: 635-41.
- 11. Allan TM. ABO blood groups and age groups in surgical venous thromboembolism. Atherosclerosis 1976; 23: 141-2.
- 12. Jick H, Porter J. Thrombophlebitis of the lower extremities and ABO blood type. Arch Intern Med 1978; 138: 1566-7.
- 13. Gonzalez Ordonez AJ, Medina Rodriguez JM, Martin L, Alvarez V, Coto E. The O blood group protects against venous thromboembolismin individuals with the factor V Leiden but not the prothrombin (factor II G20210A) mutation. Blood Coagul Fibrinolysis 1999; 10: 303-7.
- 14. Yang N, Zhang B, Xie L, et al. The association baseline NIH Stroke Scales core with ABO bloodsubtypes in young patients withacute ischemicstroke. Atherosclerosis 2014; 236: 144-9.
- 15. Sabino AP, Ribeiro DD, Domingheti CP. ABO blood group polymorphisms and risk for ischemic stroke and peripheral arterial disease. Mol Biol Rep 2014; 41: 1771-7.
- 16. Akın G, Dostbil N. Türkiye’de Kan Grubu Araştırmaları. Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 2005; 45:1-15.
- 17. Lo´pez JA, Chen J. Pathophysiology of venous thrombosis. Thromb Res 2009; 123 (suppl 4): 30-4.
- 18. Bernardo A, Ball C, Nolasco L, Choi H, Moake JL, Dong JF. Platelet s adhered to endothelial cell-bound ultra-large vonWillebrand factor strings support leukocyte tethering and Rolling under high shear stress. J Thromb Haemost 2005; 3: 562-70.
- 19. Wick TM, Moake JL, Udden MM, Eskin SG, Sears DA, McIntire LV. Unusually large vonWillebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. J Clin Invest 1987; 80: 905-10.
- 20. WuO,Bayoumı N, VıckersMa, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost 2008; 6: 62-9.
There are 20 citations in total.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | September 19, 2017 |
| Acceptance Date | June 9, 2017 |
| Published in Issue | Year 2017 |