Abstract
Derinin invaziv ve agresif kanseri olan malign
melanoma diğer kanserlere göre daha fazla mortalite ve morbiditeye neden
olmaktadır. Jinekolojik sistem primer melanomları, genital mukoza epitelindeki
melanositlerden gelişen bir grup bozukluğu içermektedir. Melanom, cildin
kutanöz kısmının yanısıra mukozal alanları (vulva gibi) da etkiler. Vulva hem
kutanöz hem de mukozal cildi içerir; klitoris, labium minor/major, mons pubis
ve üretra ve vajina açıklıklarını içermektedir. Burada biz, vulvar malign
melanomun iki farklı uç prezentasyonlarını ve tedavilerini sunmayı amaçladık.
Keywords
References
- 1. Bishop KD, Olszewski AJ. Epidemiology and survival outcomes of ocular and mucosal melanomas: A population-based analysis. Int J Cancer 2014; 134: 2961-71.
- 2. Sugiyama VE, Chan JK, Kapp DS. Management of melanomas of the female genital tract. Curr Opin Oncol 2008; 20: 565-9.
- 3. Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol 2008; 9: 973-81.
- 4. Sugiyama VE, Chan JK, Shin JY, Berek JS, Osann K, Kapp DS. Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol 2007; 110: 296-301.
- 5. Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009; 27: 6199-206.
- 6. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010; 17: 1471-4.
- 7. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009; 105: 103-4.
- 8. Ross MI, HMA. Mucosal melanoma. In: Balch CM HCM, Sober AJ, Soong S, Atkins MB, Thompson JF, editors. Cutaneous melanoma. 5th ed. St. Louis: Quality Medical Publishing; 2009; Chapter 15.
- 9. Moxley KM, Fader AN, Rose PG, et al. Malignant melanoma of the vulva: an extension of cutaneous melanoma? Gynecol Oncol 2011; 122: 612-7.
- 10. Ragnarsson-Olding BK. Primary malignant melanoma of the vulva–an aggressive tumor for modeling the genesis of non-UV light-associated melanomas. Acta Oncol 2004; 43: 421-35.
- 11. DeMatos P, Tyler D, Seigler HF. Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medical Center. Surgery 1998; 124: 38-48.
- 12. Brand E, Fu YS, Lagasse LD, Berek JS. Vulvovaginal melanoma: report of seven cases and literature review. Gynecol Oncol 1989; 33: 54-60.
- 13. De Hullu JA, Hollema H, Hoekstra HJ, et al. Vulvar melanoma: is there a role for sentinel lymph node biopsy? Cancer 2002; 94: 486-91.
- 14. Busam KJ. Molecular pathology of melanocytic tumors. Sem Diagn Pathol 2013; 30: 362-74.
- 15. Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA 2011; 305: 2327-34.
Abstract
Malignant melanoma (MM), an invasive and aggressive cancer of the skin,
causes distressing mortality and morbidity than other cancers. Gynaecological
tract primary melanomas include a class of disorders that develop from
melanocytes existing in the epithelium of the genital mucosa. Melanoma affects
mucosal sites (such as vulva) as well as cutaneous part of the skin. The vulva
includes both cutaneous and mucosal skin, and involves clitoris, labia
minora/majora, the mons pubis, and the openings of the urethra and vagina.
Herein, we aimed to present two cases with two different extreme presentations
of vulvar MM, and subsequent treatments we intended to perform.
Keywords
References
- 1. Bishop KD, Olszewski AJ. Epidemiology and survival outcomes of ocular and mucosal melanomas: A population-based analysis. Int J Cancer 2014; 134: 2961-71.
- 2. Sugiyama VE, Chan JK, Kapp DS. Management of melanomas of the female genital tract. Curr Opin Oncol 2008; 20: 565-9.
- 3. Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol 2008; 9: 973-81.
- 4. Sugiyama VE, Chan JK, Shin JY, Berek JS, Osann K, Kapp DS. Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol 2007; 110: 296-301.
- 5. Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009; 27: 6199-206.
- 6. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010; 17: 1471-4.
- 7. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009; 105: 103-4.
- 8. Ross MI, HMA. Mucosal melanoma. In: Balch CM HCM, Sober AJ, Soong S, Atkins MB, Thompson JF, editors. Cutaneous melanoma. 5th ed. St. Louis: Quality Medical Publishing; 2009; Chapter 15.
- 9. Moxley KM, Fader AN, Rose PG, et al. Malignant melanoma of the vulva: an extension of cutaneous melanoma? Gynecol Oncol 2011; 122: 612-7.
- 10. Ragnarsson-Olding BK. Primary malignant melanoma of the vulva–an aggressive tumor for modeling the genesis of non-UV light-associated melanomas. Acta Oncol 2004; 43: 421-35.
- 11. DeMatos P, Tyler D, Seigler HF. Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medical Center. Surgery 1998; 124: 38-48.
- 12. Brand E, Fu YS, Lagasse LD, Berek JS. Vulvovaginal melanoma: report of seven cases and literature review. Gynecol Oncol 1989; 33: 54-60.
- 13. De Hullu JA, Hollema H, Hoekstra HJ, et al. Vulvar melanoma: is there a role for sentinel lymph node biopsy? Cancer 2002; 94: 486-91.
- 14. Busam KJ. Molecular pathology of melanocytic tumors. Sem Diagn Pathol 2013; 30: 362-74.
- 15. Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA 2011; 305: 2327-34.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | March 20, 2018 |
| Acceptance Date | March 1, 2018 |
| Published in Issue | Year 2018 |