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Usefulness of the neutrophil-to-lymphocyte ratio to prediction of complications in type 2 diabetes mellitus

Year 2018, , 400 - 407, 29.12.2018

Abdulhalim Senyigit

https://doi.org/10.7197/223.vi.470380

Abstract

Introduction:
Increasing evidences show that the concept of type 2 diabetes
mellitus (T2DM) as an inflammatory disease has emerged. The aim of the present
study was to investigate the role of neutrophil-to-lymphocyte ratio (NLR) in
T2DM patients comparing with the other well-known inflammatory markers as C-reactive
protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen. It also
investigates usefulness of the NLR to prediction of complications in T2DM. Methods: This study consisted of six
patients groups in XXXXXX Hospital between April-October, 2017: It enrolled the
laboratory results of 195 subjects of which diabetic group (DM) (n=35), coronary
artery disease (CAD) group (n=35), CAD+DM group (n=35), DM+nephropathy (n=30),
DM+neuropathy (n=30), DM+retinopathy (n=30), and 40 healthy controls. Results: The mean NLR values were significantly higher in all
patients than controls. CAD+DM
group has the highest NLR values (4.17±3.85) among the
groups. There was no significant difference between the DM+nephropathy,
DM+neuropathy, and DM+retinopathy. The mean NLR values were significantly
higher in CAD+ DM group than DM+nephropathy, DM+neuropathy, and DM+retinopathy (for each comparison p<0.01).
 There was no statistically significant difference
in the mean NLR values between CAD group and CAD+DM group. Conclusion: Results of study demonstrate a possible association of
subclinical inflammation with the development of complications in T2DM. NLR is independently associated with other
well-known inflammatory markers as CRP, ESR and fibrinogen, inflammation in
development of complications in T2DM. NLR values in prediction of complications
in T2DM are a useful parameter. During complications of T2DM, NLR may be useful used as an easily measurable, noninvasive,
available and cost-effective parameter in clinical practice.

Keywords

Type 2 diabetes mellitus neutrophil-to-lymphocyte ratio C-reactive protein erythrocyte sedimentation rate

References

  • 1. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011; 11:98-107.
  • 2. Sargın MA, Yassa M, Taymur BD, Celik A, Ergun E, Tug N. Neutrophil-to lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy? Ther Clin Risk Manag. 2016; 12:657-65.
  • 3. Yilmaz H, Ucan B, Sayki M, Unsal I, Sahin M, Ozbek M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015; 9:299-304.
  • 4. Ayhan H, Kasapkara HA, Aslan AN, Durmaz T, Keleş T, Akçay M, et al. Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus. Can J Diabetes. 2015; 39: 317-21.
  • 5. Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015; 8: 11420-7.
  • 6. Tanındı A, Erkan AF, Alhan A, Töre HF. Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease. Anatol J Cardiol. 2015; 15: 396-403.
  • 7. Ciray H, Aksoy AH, Ulu N, Cizmecioglu A, Gaipov A, Solak Y. Nephropathy, but not Angiographically Proven Retinopathy, is Associated with Neutrophil to Lymphocyte Ratio in Patients with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2015; 123: 267-71.
  • 8. Bakirci EM, Demirtas L, Degirmenci H, Topcu S, Demirelli S, Hamur H, et al. Relationship of the total atrial conduction time to subclinical atherosclerosis, inflammation and echocardiographic parameters in patients with type 2 diabetes mellitus. Clinics (Sao Paulo). 2015; 70: 73-80.
  • 9. Ulu SM, Dogan M, Ahsen A, Altug A, Demir K, Acartürk G, et al. Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy. Diabetes Technol Ther. 2013; 15: 942-7.
  • 10. Akbas EM, Demirtas L, Ozcicek A, Timuroglu A, Bakirci EM, Hamur H, et al. Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. Int J Clin Exp Med. 2014; 7: 1794-801.
  • 11. Zhang J, Gong F, Li L, Zhao M, Song J. Diabetes mellitus and the neutrophil to lymphocyte ratio predict overall survival in non-viral hepatocellular carcinoma treated with transarterial chemoembolization. Oncol Lett. 2014; 7: 1704-10.
  • 12. Yilmaz H, Celik HT, Namuslu M, Inan O, Onaran Y, Karakurt F, et al. Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women. Exp Clin Endocrinol Diabetes. 2014; 122: 39-43.
  • 13. Kalaycıoğlu E, Gökdeniz T, Aykan AC, Gül I, Boyacı F, Gürsoy OM, et al. Comparison of neutrophil to lymphocyte ratio in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Kardiol Pol. 2014; 72: 372-80.
  • 14. Öztürk ZA, Kuyumcu ME, Yesil Y, Savas E, Yıldız H, Kepekçi Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest. 2013; 36: 593-9.
  • 15. Lee GK, Lee LC, Chong E, Lee CH, Teo SG, Chia BL, et al. The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction. QJM. 2012; 105: 1075-82.
  • 16. Azab B, Daoud J, Naeem FB, Nasr R, Ross J, Ghimire P, et al. Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study). Ren Fail. 2012; 34: 571-6.
  • 17. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015; 15: 9.
  • 18. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010 Jan; 33 (Supplement 1): S62-S69.
  • 19. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al.; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206-52.
  • 20. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endo Disord 2015; 15: 9.
  • 21. Fawwad A, Butt AM, Siddiqui IA, Khalid M, Sabir R, Basit A. Neutrophil-to-lymphocyte ratio and microvascular complications in subjects with type 2 diabetes: Pakistan’s perspective. Turk J Med Sci. 2018; 48: 157-161.
  • 22. Moursy EY, Megallaa MH, Mouftah RF, Ahmed SM. Relationship between neutrophil lymphocyte ratio and microvascular complications in Egyptian patients with type 2 diabetes. Am J Intern Med 2015; 3: 250-5.
  • 23. Yue S, Zhang J, Wu J, Teng W, Liu L, Chen L. Use of the Monocyte-to-Lymphocyte Ratio to Predict Diabetic Retinopathy. Int J Environ Res Public Health. 2015; 12: 10009-19.
  • 24. Chittawar S, Dutta D, Qureshi Z, Surana V, Khandare S, Dubey TN. Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes. Indian J Endocrinol Metab. 2017; 21: 864-70.
  • 25. Tanındı A, Erkan AF, Ekici B, Alhan A, Töre HF. Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion. Turk Kardiyol Dern Ars. 2014; 42: 125-30.
  • 26. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107: 499-511.
  • 27. Koza Y, Taş MH, Simşek Z, Ateş ES. The relationship between neutrophil-to-lymphocyte ratio and coronary artery disease. Anadolu Kardiyol Derg. 2014; 14: 99-101.
  • 28. Gabbasov Z, Kozlov S, Melnikov I, Byazrova S, Saburova O, Prokofieva L, et al. Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease. Clin Appl Thromb Hemost. 2018 Jan 1:1076029618771752. doi: 10.1177/1076029618771752. [Epub ahead of print].
  • 29. Kim BJ, Cho SH, Cho KI, Kim HS, Heo JH, Cha TJ. The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis. J Cardiovasc Ultrasound. 2016; 24: 115-22.
  • 30. Verdoia M, Schaffer A, Barbieri L, Aimaretti G, Marino P, Sinigaglia F, et al.; Novara Atherosclerosis Study Group (NAS). Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease. Diabetes Metab. 2015; 41: 304-11.

Usefulness of the neutrophil-to-lymphocyte ratio to prediction of complications in type 2 diabetes mellitus

Year 2018, , 400 - 407, 29.12.2018

Abdulhalim Senyigit

https://doi.org/10.7197/223.vi.470380

Abstract

Introduction:
Increasing evidences show that the concept of type 2 diabetes
mellitus (T2DM) as an inflammatory disease has emerged. The aim of the present
study was to investigate the role of neutrophil-to-lymphocyte ratio (NLR) in
T2DM patients comparing with the other well-known inflammatory markers as C-reactive
protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen. It also
investigates usefulness of the NLR to prediction of complications in T2DM. Methods: This study consisted of six
patients groups in XXXXXX Hospital between April-October, 2017: It enrolled the
laboratory results of 195 subjects of which diabetic group (DM) (n=35), coronary
artery disease (CAD) group (n=35), CAD+DM group (n=35), DM+nephropathy (n=30),
DM+neuropathy (n=30), DM+retinopathy (n=30), and 40 healthy controls. Results: The mean NLR values were significantly higher in all
patients than controls. CAD+DM
group has the highest NLR values (4.17±3.85) among the
groups. There was no significant difference between the DM+nephropathy,
DM+neuropathy, and DM+retinopathy. The mean NLR values were significantly
higher in CAD+ DM group than DM+nephropathy, DM+neuropathy, and DM+retinopathy (for each comparison p<0.01).
 There was no statistically significant difference
in the mean NLR values between CAD group and CAD+DM group. Conclusion: Results of study demonstrate a possible association of
subclinical inflammation with the development of complications in T2DM. NLR is independently associated with other
well-known inflammatory markers as CRP, ESR and fibrinogen, inflammation in
development of complications in T2DM. NLR values in prediction of complications
in T2DM are a useful parameter. During complications of T2DM, NLR may be useful used as an easily measurable, noninvasive,
available and cost-effective parameter in clinical practice.



 

Keywords

Type 2 diabetes mellitus neutrophil-to-lymphocyte ratio C-reactive protein erythrocyte sedimentation rate

References

  • 1. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011; 11:98-107.
  • 2. Sargın MA, Yassa M, Taymur BD, Celik A, Ergun E, Tug N. Neutrophil-to lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy? Ther Clin Risk Manag. 2016; 12:657-65.
  • 3. Yilmaz H, Ucan B, Sayki M, Unsal I, Sahin M, Ozbek M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015; 9:299-304.
  • 4. Ayhan H, Kasapkara HA, Aslan AN, Durmaz T, Keleş T, Akçay M, et al. Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus. Can J Diabetes. 2015; 39: 317-21.
  • 5. Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015; 8: 11420-7.
  • 6. Tanındı A, Erkan AF, Alhan A, Töre HF. Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease. Anatol J Cardiol. 2015; 15: 396-403.
  • 7. Ciray H, Aksoy AH, Ulu N, Cizmecioglu A, Gaipov A, Solak Y. Nephropathy, but not Angiographically Proven Retinopathy, is Associated with Neutrophil to Lymphocyte Ratio in Patients with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2015; 123: 267-71.
  • 8. Bakirci EM, Demirtas L, Degirmenci H, Topcu S, Demirelli S, Hamur H, et al. Relationship of the total atrial conduction time to subclinical atherosclerosis, inflammation and echocardiographic parameters in patients with type 2 diabetes mellitus. Clinics (Sao Paulo). 2015; 70: 73-80.
  • 9. Ulu SM, Dogan M, Ahsen A, Altug A, Demir K, Acartürk G, et al. Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy. Diabetes Technol Ther. 2013; 15: 942-7.
  • 10. Akbas EM, Demirtas L, Ozcicek A, Timuroglu A, Bakirci EM, Hamur H, et al. Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. Int J Clin Exp Med. 2014; 7: 1794-801.
  • 11. Zhang J, Gong F, Li L, Zhao M, Song J. Diabetes mellitus and the neutrophil to lymphocyte ratio predict overall survival in non-viral hepatocellular carcinoma treated with transarterial chemoembolization. Oncol Lett. 2014; 7: 1704-10.
  • 12. Yilmaz H, Celik HT, Namuslu M, Inan O, Onaran Y, Karakurt F, et al. Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women. Exp Clin Endocrinol Diabetes. 2014; 122: 39-43.
  • 13. Kalaycıoğlu E, Gökdeniz T, Aykan AC, Gül I, Boyacı F, Gürsoy OM, et al. Comparison of neutrophil to lymphocyte ratio in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Kardiol Pol. 2014; 72: 372-80.
  • 14. Öztürk ZA, Kuyumcu ME, Yesil Y, Savas E, Yıldız H, Kepekçi Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest. 2013; 36: 593-9.
  • 15. Lee GK, Lee LC, Chong E, Lee CH, Teo SG, Chia BL, et al. The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction. QJM. 2012; 105: 1075-82.
  • 16. Azab B, Daoud J, Naeem FB, Nasr R, Ross J, Ghimire P, et al. Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study). Ren Fail. 2012; 34: 571-6.
  • 17. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015; 15: 9.
  • 18. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010 Jan; 33 (Supplement 1): S62-S69.
  • 19. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al.; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206-52.
  • 20. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endo Disord 2015; 15: 9.
  • 21. Fawwad A, Butt AM, Siddiqui IA, Khalid M, Sabir R, Basit A. Neutrophil-to-lymphocyte ratio and microvascular complications in subjects with type 2 diabetes: Pakistan’s perspective. Turk J Med Sci. 2018; 48: 157-161.
  • 22. Moursy EY, Megallaa MH, Mouftah RF, Ahmed SM. Relationship between neutrophil lymphocyte ratio and microvascular complications in Egyptian patients with type 2 diabetes. Am J Intern Med 2015; 3: 250-5.
  • 23. Yue S, Zhang J, Wu J, Teng W, Liu L, Chen L. Use of the Monocyte-to-Lymphocyte Ratio to Predict Diabetic Retinopathy. Int J Environ Res Public Health. 2015; 12: 10009-19.
  • 24. Chittawar S, Dutta D, Qureshi Z, Surana V, Khandare S, Dubey TN. Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes. Indian J Endocrinol Metab. 2017; 21: 864-70.
  • 25. Tanındı A, Erkan AF, Ekici B, Alhan A, Töre HF. Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion. Turk Kardiyol Dern Ars. 2014; 42: 125-30.
  • 26. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107: 499-511.
  • 27. Koza Y, Taş MH, Simşek Z, Ateş ES. The relationship between neutrophil-to-lymphocyte ratio and coronary artery disease. Anadolu Kardiyol Derg. 2014; 14: 99-101.
  • 28. Gabbasov Z, Kozlov S, Melnikov I, Byazrova S, Saburova O, Prokofieva L, et al. Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease. Clin Appl Thromb Hemost. 2018 Jan 1:1076029618771752. doi: 10.1177/1076029618771752. [Epub ahead of print].
  • 29. Kim BJ, Cho SH, Cho KI, Kim HS, Heo JH, Cha TJ. The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis. J Cardiovasc Ultrasound. 2016; 24: 115-22.
  • 30. Verdoia M, Schaffer A, Barbieri L, Aimaretti G, Marino P, Sinigaglia F, et al.; Novara Atherosclerosis Study Group (NAS). Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease. Diabetes Metab. 2015; 41: 304-11.

Year 2018, , 400 - 407, 29.12.2018

Abdulhalim Senyigit

https://doi.org/10.7197/223.vi.470380

Abstract

References

  • 1. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011; 11:98-107.
  • 2. Sargın MA, Yassa M, Taymur BD, Celik A, Ergun E, Tug N. Neutrophil-to lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy? Ther Clin Risk Manag. 2016; 12:657-65.
  • 3. Yilmaz H, Ucan B, Sayki M, Unsal I, Sahin M, Ozbek M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015; 9:299-304.
  • 4. Ayhan H, Kasapkara HA, Aslan AN, Durmaz T, Keleş T, Akçay M, et al. Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus. Can J Diabetes. 2015; 39: 317-21.
  • 5. Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A, Gurel A, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015; 8: 11420-7.
  • 6. Tanındı A, Erkan AF, Alhan A, Töre HF. Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease. Anatol J Cardiol. 2015; 15: 396-403.
  • 7. Ciray H, Aksoy AH, Ulu N, Cizmecioglu A, Gaipov A, Solak Y. Nephropathy, but not Angiographically Proven Retinopathy, is Associated with Neutrophil to Lymphocyte Ratio in Patients with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2015; 123: 267-71.
  • 8. Bakirci EM, Demirtas L, Degirmenci H, Topcu S, Demirelli S, Hamur H, et al. Relationship of the total atrial conduction time to subclinical atherosclerosis, inflammation and echocardiographic parameters in patients with type 2 diabetes mellitus. Clinics (Sao Paulo). 2015; 70: 73-80.
  • 9. Ulu SM, Dogan M, Ahsen A, Altug A, Demir K, Acartürk G, et al. Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy. Diabetes Technol Ther. 2013; 15: 942-7.
  • 10. Akbas EM, Demirtas L, Ozcicek A, Timuroglu A, Bakirci EM, Hamur H, et al. Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. Int J Clin Exp Med. 2014; 7: 1794-801.
  • 11. Zhang J, Gong F, Li L, Zhao M, Song J. Diabetes mellitus and the neutrophil to lymphocyte ratio predict overall survival in non-viral hepatocellular carcinoma treated with transarterial chemoembolization. Oncol Lett. 2014; 7: 1704-10.
  • 12. Yilmaz H, Celik HT, Namuslu M, Inan O, Onaran Y, Karakurt F, et al. Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women. Exp Clin Endocrinol Diabetes. 2014; 122: 39-43.
  • 13. Kalaycıoğlu E, Gökdeniz T, Aykan AC, Gül I, Boyacı F, Gürsoy OM, et al. Comparison of neutrophil to lymphocyte ratio in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Kardiol Pol. 2014; 72: 372-80.
  • 14. Öztürk ZA, Kuyumcu ME, Yesil Y, Savas E, Yıldız H, Kepekçi Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest. 2013; 36: 593-9.
  • 15. Lee GK, Lee LC, Chong E, Lee CH, Teo SG, Chia BL, et al. The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction. QJM. 2012; 105: 1075-82.
  • 16. Azab B, Daoud J, Naeem FB, Nasr R, Ross J, Ghimire P, et al. Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study). Ren Fail. 2012; 34: 571-6.
  • 17. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015; 15: 9.
  • 18. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010 Jan; 33 (Supplement 1): S62-S69.
  • 19. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al.; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206-52.
  • 20. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endo Disord 2015; 15: 9.
  • 21. Fawwad A, Butt AM, Siddiqui IA, Khalid M, Sabir R, Basit A. Neutrophil-to-lymphocyte ratio and microvascular complications in subjects with type 2 diabetes: Pakistan’s perspective. Turk J Med Sci. 2018; 48: 157-161.
  • 22. Moursy EY, Megallaa MH, Mouftah RF, Ahmed SM. Relationship between neutrophil lymphocyte ratio and microvascular complications in Egyptian patients with type 2 diabetes. Am J Intern Med 2015; 3: 250-5.
  • 23. Yue S, Zhang J, Wu J, Teng W, Liu L, Chen L. Use of the Monocyte-to-Lymphocyte Ratio to Predict Diabetic Retinopathy. Int J Environ Res Public Health. 2015; 12: 10009-19.
  • 24. Chittawar S, Dutta D, Qureshi Z, Surana V, Khandare S, Dubey TN. Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes. Indian J Endocrinol Metab. 2017; 21: 864-70.
  • 25. Tanındı A, Erkan AF, Ekici B, Alhan A, Töre HF. Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion. Turk Kardiyol Dern Ars. 2014; 42: 125-30.
  • 26. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107: 499-511.
  • 27. Koza Y, Taş MH, Simşek Z, Ateş ES. The relationship between neutrophil-to-lymphocyte ratio and coronary artery disease. Anadolu Kardiyol Derg. 2014; 14: 99-101.
  • 28. Gabbasov Z, Kozlov S, Melnikov I, Byazrova S, Saburova O, Prokofieva L, et al. Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease. Clin Appl Thromb Hemost. 2018 Jan 1:1076029618771752. doi: 10.1177/1076029618771752. [Epub ahead of print].
  • 29. Kim BJ, Cho SH, Cho KI, Kim HS, Heo JH, Cha TJ. The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis. J Cardiovasc Ultrasound. 2016; 24: 115-22.
  • 30. Verdoia M, Schaffer A, Barbieri L, Aimaretti G, Marino P, Sinigaglia F, et al.; Novara Atherosclerosis Study Group (NAS). Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease. Diabetes Metab. 2015; 41: 304-11.
There are 30 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Medical Science Research Articles
Authors

Abdulhalim Senyigit

Publication Date December 29, 2018
Acceptance Date December 16, 2018
Published in Issue Year 2018

Cite

AMA Senyigit A. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of complications in type 2 diabetes mellitus. CMJ. December 2018;40(4):400-407. doi:10.7197/223.vi.470380