Research Article
Year 2019,
, 244 - 249, 30.06.2019
Abstract
Objective: Epilepsy is a neurological disease characterized by
seizures that can affect all age groups. Experimental epilepsy models have been
used in order to prevent and treat epileptic seizures. Bisphenol A (BPA) is
found in the plastics that are used in our daily lives, and causes harmful
effects on the central nervous system. In this study, we aimed to investigate
the effect of BPA in penicillin-induced epileptiform activity.
Method: Male Wistar rats weighing 205 ± 220 grams were
separated into 4 groups: Control (n=7), 125 μg/kg BPA (n=7), 250 μg/kg BPA
(n=7) and 500 μg/kg BPA (n=7). Rats were anesthetized with urethane, and were fixed
to a stereotaxic device. With the stereotaxic guidance, an electrode was placed
over the left somotomotor cortex and it connected to the recorder. 500 IU
penicillin G was administered intracortically for induction of epileptiform
activity. After 30 minutes from penicillin injection, the doses of BPA or olive
oil were administered intraperitoneally and electrocorticography recording
continued for 180 minutes after drug injection.
Results: BPA, at a dose of 125 μg/kg, did not significantly
change either the means of spike frequency or amplitude when compared to the
control group. BPA, at the doses of 250 and 500 μg/kg, showed proconvulsant
activity by increasing the mean spike frequency in the 50 and 40 minutes
(respectively) until the end of the experiment without changing the amplitude.
Conclusions: The results of the present study provide
electrophysiological evidence that BPA increase the epileptiform activity.
Therefore, we suggest that epilepsy patients should avoid exposure to BPA.
References
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- Biziere K, Chambon JP. Animal models of epilepsy and experimental seizures. Rev Neurol 1987; 143: 329-40.
- Sagratella S, Niglio T, Scotti de Carolis A. An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits. Pharmacol Res Commun 1985; 17: 773-86
- Hill RG, Simmonds MA, Straughan DW. Antagonism of gamma-aminobutyric acid and glycine by convulsants in the cuneate nucleus of cat. Br J Pharmacol 1976; 56(1): 9-19.
- Vandenberg LN, Maffini MV, Sonnenschein C, et al. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev 2009; 30: 75-95.
- Kang JH, Kondo F, Katayama Y. Human exposure to bisphenol A. Toxicology. 2006; 226: 79-89.
- Wilson NK, Chuang JC, Morgan MK, et al. An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare. Environ Res 2007; 103: 9-20.
- Ratajczak-Wrona W, Nowak K, Garley M, Tynecka M and Jablonska E. Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils. Human and Experimental Toxicology 2019; 38(2): 239–246.
- Gatimel N, Lacroix MZ, Chanthavisouk S, et al. Bisphenol A in culture media and plastic consumables used for ART. Hum Reprod 2016; 31: 1436-1444.
- Vandenberg LN, Hunt PA, Myers JP, et al. Human exposures to bisphenol A: mismatches between data and assumptions. Rev Environ Health 2013; 28: 37–58.
- Kawai K, Nozaki T, Nishikata H, et al. Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A. Environ Health Perspect 2003; 111: 175-178.
- Miyagawa K, Narita M, Narita M, et al. Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposure to bisphenol-A. Neurosci Lett 2007; 418: 236-241.
- Tian YH, Baek JH, Lee SY, et al. Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice. Synapse 2010; 64:432-439.
- Ishido M, Masuo Y, Terasaki M, et al. Rat hyperactivity by bisphenol A, but not by its derivatives, 3-hydroxybisphenol A or bisphenol A 3,4-quinone. Toxicol Lett 2011; 206: 300-305.
- Arslan G, Ayyildiz M, Agar E. The interaction between ghrelin and cannabinoid systems in penicillin-induced epileptiform activity in rats. Neuropeptides 2014; 48(6): 345–352.
- Arslan G, Alici SK, Ayyildiz M, Agar E. Interaction between urethane and cannabinoid CB1 receptor agonist and antagonist in penicillin‑induced epileptiform activity. Acta Neurobiol Exp 2017, 77: 128-136.
- Kang JH, Kondo F, Katayama Y. Human exposure to bisphenol A. Toxicology 2006; 226: 79-89.
- Choi IS, Cho JH, Park EJ, Park JW, Kim SH, Lee MG, Choi BJ, Jang IS. Multiple effects of bisphenol A, an endocrine disrupter, on GABA(A) receptors in acutely dissociated rat CA3 pyramidal neurons. Neurosci Res 2007; 59(1): 8-17.
- Palanza, P, Gioiosa L, Vomsaal F, Parmigiani S. Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environmental Research 2008; 108(2): 150-157.
- Alonso-Magdalena P, Ropero AB, Soriano S, García-Arévalo M, Ripoll C, Fuentes E, Quesada I, Nadal Á. Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways. Mol. Cell. Endocrinol 2012; 355: 201-207.
- Soriano S, Alonso-Magdalena P, Garcia-Arevalo M, Novials A, Muhammed SJ, Salehi A, Gustafsson JA, Quesada I, Nadal A. Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor beta. PLoS One 2012 355(2): 201-7.
- Prince DA. Topical convulsant drugs and metabolic antagonists. In: Purpura DP, Penry JK, Tower DB, Woodbory DM, Walter RD (eds). Experimental models of epilepsy. New York: Raven Press, 1972; pp 51–83.
- Ahmad A, Vohora D. Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model. Neurol Sci 2014; 35: 1561-1566.
- Jardim NS, Sartori G, Sari MHM, Müller SG, Nogueira CW. Bisphenol A impairs the memory function and glutamatergic homeostasis in a sex-dependent manner in mice: Beneficial effects of diphenyl diselenide. Toxicology and Applied Pharmacology 2017; 329: 75-84.
Year 2019,
, 244 - 249, 30.06.2019
Abstract
References
- Dichter MA. The epilepsies and convulsive disorders.. In: Isselbacher KJ (Ed). Harrison's Principles of Internal Medicine. New York: McGraw-Hill, 1994; pp 2223-33.
- Biziere K, Chambon JP. Animal models of epilepsy and experimental seizures. Rev Neurol 1987; 143: 329-40.
- Sagratella S, Niglio T, Scotti de Carolis A. An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits. Pharmacol Res Commun 1985; 17: 773-86
- Hill RG, Simmonds MA, Straughan DW. Antagonism of gamma-aminobutyric acid and glycine by convulsants in the cuneate nucleus of cat. Br J Pharmacol 1976; 56(1): 9-19.
- Vandenberg LN, Maffini MV, Sonnenschein C, et al. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev 2009; 30: 75-95.
- Kang JH, Kondo F, Katayama Y. Human exposure to bisphenol A. Toxicology. 2006; 226: 79-89.
- Wilson NK, Chuang JC, Morgan MK, et al. An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare. Environ Res 2007; 103: 9-20.
- Ratajczak-Wrona W, Nowak K, Garley M, Tynecka M and Jablonska E. Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils. Human and Experimental Toxicology 2019; 38(2): 239–246.
- Gatimel N, Lacroix MZ, Chanthavisouk S, et al. Bisphenol A in culture media and plastic consumables used for ART. Hum Reprod 2016; 31: 1436-1444.
- Vandenberg LN, Hunt PA, Myers JP, et al. Human exposures to bisphenol A: mismatches between data and assumptions. Rev Environ Health 2013; 28: 37–58.
- Kawai K, Nozaki T, Nishikata H, et al. Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A. Environ Health Perspect 2003; 111: 175-178.
- Miyagawa K, Narita M, Narita M, et al. Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposure to bisphenol-A. Neurosci Lett 2007; 418: 236-241.
- Tian YH, Baek JH, Lee SY, et al. Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice. Synapse 2010; 64:432-439.
- Ishido M, Masuo Y, Terasaki M, et al. Rat hyperactivity by bisphenol A, but not by its derivatives, 3-hydroxybisphenol A or bisphenol A 3,4-quinone. Toxicol Lett 2011; 206: 300-305.
- Arslan G, Ayyildiz M, Agar E. The interaction between ghrelin and cannabinoid systems in penicillin-induced epileptiform activity in rats. Neuropeptides 2014; 48(6): 345–352.
- Arslan G, Alici SK, Ayyildiz M, Agar E. Interaction between urethane and cannabinoid CB1 receptor agonist and antagonist in penicillin‑induced epileptiform activity. Acta Neurobiol Exp 2017, 77: 128-136.
- Kang JH, Kondo F, Katayama Y. Human exposure to bisphenol A. Toxicology 2006; 226: 79-89.
- Choi IS, Cho JH, Park EJ, Park JW, Kim SH, Lee MG, Choi BJ, Jang IS. Multiple effects of bisphenol A, an endocrine disrupter, on GABA(A) receptors in acutely dissociated rat CA3 pyramidal neurons. Neurosci Res 2007; 59(1): 8-17.
- Palanza, P, Gioiosa L, Vomsaal F, Parmigiani S. Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environmental Research 2008; 108(2): 150-157.
- Alonso-Magdalena P, Ropero AB, Soriano S, García-Arévalo M, Ripoll C, Fuentes E, Quesada I, Nadal Á. Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways. Mol. Cell. Endocrinol 2012; 355: 201-207.
- Soriano S, Alonso-Magdalena P, Garcia-Arevalo M, Novials A, Muhammed SJ, Salehi A, Gustafsson JA, Quesada I, Nadal A. Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor beta. PLoS One 2012 355(2): 201-7.
- Prince DA. Topical convulsant drugs and metabolic antagonists. In: Purpura DP, Penry JK, Tower DB, Woodbory DM, Walter RD (eds). Experimental models of epilepsy. New York: Raven Press, 1972; pp 51–83.
- Ahmad A, Vohora D. Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model. Neurol Sci 2014; 35: 1561-1566.
- Jardim NS, Sartori G, Sari MHM, Müller SG, Nogueira CW. Bisphenol A impairs the memory function and glutamatergic homeostasis in a sex-dependent manner in mice: Beneficial effects of diphenyl diselenide. Toxicology and Applied Pharmacology 2017; 329: 75-84.
There are 24 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Basic Science Research Articles |
| Authors | |
| Publication Date | June 30, 2019 |
| Acceptance Date | May 7, 2019 |
| Published in Issue | Year 2019 |