Comparison of clinicopathologic features of young and older patients with sporadic colorectal adenocarcinoma
Abstract
Abstract
Aim. There is still considerable controversy and debate regarding the features of colorectal cancer in young and older patients. In the present study, the influence of age on clinicopathological characteristics of sporadic colorectal cancer is analyzed retrospectively. Method. A total of 170 cases of colectomy for adenocarcinoma in Kocaeli University Medical School, Turkey, Department of Surgery between January 2001 and September 2005 were studied. Results. Of the 170 patients, 40 (23.5%) were in the ≤50 age group and 130 (76.5%) in the >50 age group were included in the study. Statistical tests were applied for the variables. No differences were found between the young and older patients in respect of clinical features, histopathological features, surgical procedures, or post-operative complications. Conclusion. According to this study, there are no differences between young and older patients with sporadic colorectal adenocarcinoma in respect of clinical features, histopathological features, surgical procedures, or post-operative complications. The differences found previously as recorded in the literature may be associated with genetic variations.
Keywords: Colorectal, adenocarcinoma, sporadic
Özet
Amaç. Yaşlı ve genç yaş hastalarda kolorektal kanserlerin özellikleriyle ilgili halen süregelen tartışmalar vardır. Bu çalışmada yaşın sporadik kolorektal kanserlerin klinikopatolojik karakteristikleri üzerine etkisi retrospektif olarak incelendi. Yöntem. Ocak 2001-Eylül 2005 arasında adenokarsinom nedeniyle Kocaeli Üniversitesi Tıp Fakültesi Genel Cerrahi Kliniği’nde kolektomi yapılan toplam 170 olgu retrospektif olarak incelendi. Bulgular. Yüz yetmiş olgudan 40’ı (%23,5) elli yaş ve altında, 130’u (%76,5) elli yaşın üstünde idi. Elde edilen sonuçlar istatistiksel olarak değerlendirildi. Yaşlı ve genç hasta grupları arasında klinik özellkler, histopatolojik özellikler, uygulanan cerrahi yöntemler veya ameliyat sonrası komplikasyonlar açısından fark bulunmadı. Sonuç. Bu çalışmaya gore sporadik kolerektal adenokarsinomlu genç ve yaşlı hastalar arasında kilnik özellikler, histopatolojik özellikler, uygulanan cerrahi yöntemler veya ameliyat sonrası komplikasyonlar açısından fark yoktur. Literatürlerde belirtilen daha once saptanmış olan farklar gentetik varyasyonlarla ilişkili olabilir.
Anahtar sözcükler: Kolorektal, adenokarsinom, sporadik
Keywords
References
- Fleming ID, Cooper JS, Henson DE, Hutter RVP, Kennedy BJ, Murphy GP. American Joint Committee on Cancer (AJCC). AJCC cancer staging manual. 5th ed. Philadelphia, PA, USA: Lippincott-Raven, 1997.
- Puppa G, Sonzogni A, Colombari R, Pelosi G. TNM staging system of colorectal carcinoma: A critical appraisal of challenging issues. Arch Pathol Lab Med. 2010; 134: 837-52.
- Belov L, Zhou J, Christopherson RI. Cell surface markers in colorectal cancer prognosis. Int J Mol Sci. 2010; 12: 78-113.
- Alici S, Aykan NF, Sakar B, Bulutlar G. Colorectal cancer in young patients: Characteristics and outcome. Tohoku J Exp Med. 2003; 199: 85-93.
- Lin JT, Wang WS, Yen CC, Liu JH. Outcome of colorectal carcinoma in patients under 40 years of age. Gastroenterol Hepatol. 2005, 20: 900-5.
- Endreseth BH, Romundstad P, Myrvold HE, Hestvik UE. Rectal cancer in the young patient. Dis Colon Rectum. 2006; 49: 993-1001.
- Chiang JM, Chen MC, Changchien CR, Chen JS. Favorable influence of age on tumor characteristics of sporadic colorectal adenocarcinoma: patients 30 years of age or younger may be a distinct patient group. Dis Colon Rectum. 2003; 46: 904
- Fazeli MS, Adel MG, Lebaschi AH. Colorectal carcinoma: A retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University. Dis Colon Rectum. 2007; 50: 990
- Mostafa G, Matthews BD, Norton HJ, Kercher KW, Sing RF, Heniford BT. Influence of demographics on colorectal cancer. Am Surg. 2004; 70: 259-64.
- Li M, Li JY, Zhao AL, Gu J. Do young patients with colorectal cancer have a poorer prognosis than old patients? J Surg Res. 2011; 167: 231-6.
- Huh JW, Oh BR, Kim HR, Kim YJ. Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer. J Surg Oncol. 2010; 101: 396-400.
- Wang WS, Lin JK, Lin TC, Chiou TJ. Tumor marker CEA in monitoring of response to tegafur-uracil and folinic acid in patients with metastatic colorectal cancer. Hepatogastroenterology. 2002; 49: 388-92.
- Liang JT, Huang KC, Cheng AL, Jeng YM. Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age. Br J Surg. 2003; 90: 205-14.
Abstract
Amaç. Yaşlı ve genç yaş hastalarda kolorektal kanserlerin özellikleriyle ilgili halen süregelen tartışmalar vardır. Bu çalışmada yaşın sporadik kolorektal kanserlerin klinikopatolojik karakteristikleri üzerine etkisi retrospektif olarak incelendi. Yöntem. Ocak 2001-Eylül 2005 arasında adenokarsinom nedeniyle Kocaeli Üniversitesi Tıp Fakültesi Genel Cerrahi Kliniği’nde kolektomi yapılan toplam 170 olgu retrospektif olarak incelendi. Bulgular. Yüz yetmiş olgudan 40’ı (%23,5) elli yaş ve altında, 130’u (%76,5) elli yaşın üstünde idi. Elde edilen sonuçlar istatistiksel olarak değerlendirildi. Yaşlı ve genç hasta grupları arasında klinik özellkler, histopatolojik özellikler, uygulanan cerrahi yöntemler veya ameliyat sonrası komplikasyonlar açısından fark bulunmadı. Sonuç. Bu çalışmaya gore sporadik kolerektal adenokarsinomlu genç ve yaşlı hastalar arasında kilnik özellikler, histopatolojik özellikler, uygulanan cerrahi yöntemler veya ameliyat sonrası komplikasyonlar açısından fark yoktur. Literatürlerde belirtilen daha once saptanmış olan farklar gentetik varyasyonlarla ilişkili olabilir.
Keywords
References
- Fleming ID, Cooper JS, Henson DE, Hutter RVP, Kennedy BJ, Murphy GP. American Joint Committee on Cancer (AJCC). AJCC cancer staging manual. 5th ed. Philadelphia, PA, USA: Lippincott-Raven, 1997.
- Puppa G, Sonzogni A, Colombari R, Pelosi G. TNM staging system of colorectal carcinoma: A critical appraisal of challenging issues. Arch Pathol Lab Med. 2010; 134: 837-52.
- Belov L, Zhou J, Christopherson RI. Cell surface markers in colorectal cancer prognosis. Int J Mol Sci. 2010; 12: 78-113.
- Alici S, Aykan NF, Sakar B, Bulutlar G. Colorectal cancer in young patients: Characteristics and outcome. Tohoku J Exp Med. 2003; 199: 85-93.
- Lin JT, Wang WS, Yen CC, Liu JH. Outcome of colorectal carcinoma in patients under 40 years of age. Gastroenterol Hepatol. 2005, 20: 900-5.
- Endreseth BH, Romundstad P, Myrvold HE, Hestvik UE. Rectal cancer in the young patient. Dis Colon Rectum. 2006; 49: 993-1001.
- Chiang JM, Chen MC, Changchien CR, Chen JS. Favorable influence of age on tumor characteristics of sporadic colorectal adenocarcinoma: patients 30 years of age or younger may be a distinct patient group. Dis Colon Rectum. 2003; 46: 904
- Fazeli MS, Adel MG, Lebaschi AH. Colorectal carcinoma: A retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University. Dis Colon Rectum. 2007; 50: 990
- Mostafa G, Matthews BD, Norton HJ, Kercher KW, Sing RF, Heniford BT. Influence of demographics on colorectal cancer. Am Surg. 2004; 70: 259-64.
- Li M, Li JY, Zhao AL, Gu J. Do young patients with colorectal cancer have a poorer prognosis than old patients? J Surg Res. 2011; 167: 231-6.
- Huh JW, Oh BR, Kim HR, Kim YJ. Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer. J Surg Oncol. 2010; 101: 396-400.
- Wang WS, Lin JK, Lin TC, Chiou TJ. Tumor marker CEA in monitoring of response to tegafur-uracil and folinic acid in patients with metastatic colorectal cancer. Hepatogastroenterology. 2002; 49: 388-92.
- Liang JT, Huang KC, Cheng AL, Jeng YM. Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age. Br J Surg. 2003; 90: 205-14.
Details
| Primary Language | English |
|---|---|
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | March 28, 2014 |
| Published in Issue | Year 2014 |