Abstract
Aim. Restless legs syndrome (RLS) an ilness characterized by discomfort in the legs, rest manifested by burning and a desire to move the legs more often at night. This situation is common in hemodialysis patients and can cause insomnia. In our study, we aimed to investigate the relationship between the RLS and quality of sleep disorders. Methods. The study enrolled patients who were receiving hemodialysis. The international restless legs study group criteria were used for patients and the Pittsburg sleep quality index was used for sleep disturbance. In all patients, complete blood count, PTH, calcium, phosphorus, creatinine, iron, serum iron binding capacity and ferritin levels were evaluated. Results. The study enrolled 112 hemodialysis patients. The mean age of patients was 56.8 ± 16.2. In patients 61.6% the disorder in sleep quality was detected and in 66.1% the RLS was detected. A significant relationship between quality of sleep disorders and RLS (p<0.05) were detected. A significant association among disorders in sleep quality and RLS anemia, PTH, calcium and phosphorus levels were not detected. Conclusion. In our study, a significant relationship between quality of sleep disorders and RLS was detected. In hemodialysis patients, disorders in sleep quality and RLS is more common, but its etiology is unclear. Due to RLS symptoms more often at the night it is thought to be lead to quality of sleep disorders
References
- Bassetti CL, Mauerhofer D, Gugger M, Mathiss J, Hess CW. Restless legs syndrome: a clinical study of 55 patients. Eur Neurol 2001; 45: 67-74.
- Krishnan PR, Bhatia M, Behari M. Restless legs syndrome in Parkinson’s disdease: a case controlled study. Mov disord 2003; 18: 181-5.
- O’Keeffe ST. Restless legs syndrome. Arch Intern Med 1996; 156: 243-8.
- Tan EK, Ondo W. Restless legs syndrome: Clinical features and treatment. Am Med Sci 2000; 319: 397-403.
- Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, Trenkwalder C. International Restless Legs Syndrome Study Group. Validation of international restless legs syndrome study group rating scale for restless legs syndrome. Sleep med 2003; 4: 121-32.
- Desautels A, Turecki G, MontplaisirJ, Xiong L, Walters AS, Ehrenberg BL, Brisebois K, Desautels AK, Gingras Y, Johnson WG, Lugaresi E, Coccagna G, PicchiettiDL, Lazzarini A, Rouleau GA. Restless legs syndrome. Confirmation of linkage to chromosome 12q, genetic heterogeneity and evidence of complexity. Arch Neurol 2005; 62: 591-6.
- Hui DS, Wong TY, Li TS, Ko FW, Choy DK, Szeto CC, Lui SF, Li PK. Prevalence of sleep disturbances in Chinese patient with end stage renal failure on maintenance hemodialysis. Med Sci Monit 2002; 8: 331-6.
- Cirignotta F Mondini S, Santoro A, Ferrari G, Gerardi R, Buzzi G. Reliability of a questionnare screening restless legs syndrome in patients on chronic dialysis. Am. J. Kidney Dis 2002; 40: 302-6.
- Cornella CL. Restless legs syndrome: Treatment with dopamiergic agents. Neurology 2002; 58: 87-92.
- Germain A, Hall M, Krakow B, Katherine Shear M, Buysse DJ. A brief sleep scale for posttraumatic stress disorder: Pittsburgh sleep quality index addendum for PTSD. J Anxiety Disord 2005; 19: 233-44.
- Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer MA, Hopman WM. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant 2003; 18: 126-32.
- Beck SL, Schwartz AL, Towsley G, Dudley W, Barsevick A. Psychometric evaluation of the Pittsburg sleep quality index in cancer patients. J Pain Symptom Manage 2004; 27: 140-8.
- Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburg sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193-213.
- Buysse DJ, Reynolds CF, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburg Sleep Quality Index (PSQI) 1991; 14: 331-8.
- Kusleikaite N, Bumblyte IA, Rezukeviciene L, Sedlickaite D, Rinkunas K. Sleep disorder and quality of life in patients on hemodialysis. Medicina (Kaunas) 2005; 41: 69-74.
- Kamel NS, Gammack JK. Insomnia in the elderly: Cause, approach, and treatment. Am J Med 2006; 119: 463-9.
- Ohayon M. Epidemiological study on insomnia in the general population Sleep 1996; 19: 7-15.
- Walker S, Fine A, Kryger MH. Sleep complaints are common in a dialysis unit. Am J Kidney Dis 1995; 26: 751-6.
- Hui DS, Wong TY, Li TS, Ko FW, Choy DK, Szeto CC, Lui SF, Li PK. Prevalence of sleep disturbances in Chinese patients with end-stage renal failure on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 2000; 36: 783-8.
- Unruh ML, Levey AS, D'Ambrosio C, Fink NE, Powe NR, Meyer KB. Restless legs symptoms among incident dialysis patients: association with lower quality of life and shorter survival. Am J Kidney Dis 2004; 43: 900-9.
- Telarovic S, Relja M, Trkulja V. Restless legs syndrome in hemodialysis patients: Association with calcium antagonists. A preliminary report. Eur Neurol 2007; 58:166-9.
- Çölbay M, Yüksel Ş, Acartürk G, Uslan I, Karaman O. Huzursuz bacak sendromlu hemodiyaliz hastalarında uyku kalitesi: Genel Tıp Derg 2007; 17: 35- 41.
- Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S, Budai R. Restless legs syndrome in end-stage renal disease. Sleep Med 2004; 5: 309-15.
- Kim JM, Kwon HM, Lim CS, Kim YS, Lee SJ, Nam H. Restless Legs Syndrome in Patients on Hemodialysis: Symptom Severity and Risk Factors. J Clin Neurol 2008; 4: 153-7.
- Bhowmik D, Bhatia M, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Restless legs syndrome in hemodialysis patients in India: a case controlled study. Sleep Med 2003; 4: 143-6.
- Ferini-Strambi L, Aarskog D, Partinen M, Chaudhuri KR, Sohr M, Verri D, Albrecht S. Effect of pramipexole on RLS symptoms and sleep: A randomized, double-blind, placebo-controlled trial. Sleep Med 2008; 9: 874-1.
- Aksu M, Demirci S and Bara-Jimenez W. Correlation between putative indicators of primary restless legs syndrome severity. Sleep Med, 2007; 8: 84-9.
- Takaki J. Nishi T, Nangaku M, Shimoyama H, Inada T, Matsuyama N, Kumano H, Kuboki T. Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis. Am J Kidney Dis 2003; 41: 833-9.
- Collado-Seidel V, Kohnen R, Samtleben W, Hillebrand GF, Oertel WH, Trenkwalder C. Clinical and biochemical findings in uremic patients with and without restless legs syndrome. Am J Kidney Dis 1998; 31: 324-8.
Abstract
Amaç. Huzursuz bacak sendromu (HBS) bacaklarda huzursuzluk hissi, yanma ile kendini gösteren
istirahat ve geceleri daha sık olan bacakları hareket ettirme isteği ile karakterize bir rahatsızlıktır.
Bu durum hemodiyaliz hastalarında sıktır ve uykusuzluğa neden olabilir. Biz çalışmamızda uyku
kalitesinde bozukluk ile HBS arasındaki ilişkiyi incelemeyi amaçladık. Yöntem. Çalışmaya
hemodiyaliz programında olan hastalar alındı. Hastalara Uluslar arası huzursuz bacak çalışma
grubu tanı kriterleri kullanıldı ve uyku kalitesi bozukluğu için Pittsburg uyku kalitesi indeksi
kullanıldı. Hastaların tümünde hemogram, PTH, kalsiyum, fosfor, kreatinin, demir, serum demir
bağlama kapasitesi ve ferritin değerleri değerlendirildi. Bulgular. Çalışmaya 112 hemodiyaliz
hastası alındı. Hastaların yaş ortalaması 56,8 ± 16,2 idi. Hastaların %61,6’sında uyku kalitesinde
bozukluk ve %66,1’inde HBS tespit edildi. Uyku kalite bozukluğu ile HBS arasında anlamlı bir
ilişki (p < 0.05) saptandı. Uyku kalitesinde bozukluk ve HBS’nun anemi, PTH, kalsiyum ve fosfor
değerleriyle anlamlı bir ilişkisi saptanmadı. Sonuç. Çalışmamızda uyku kalitesinde bozukluk ile
HBS arasında anlamlı bir ilişki saptandı. Hemodiyaliz hastalarında uyku kaliteside bozukluk ve
HBS sık olmasına rağmen etyolojisi net bilinmemektedir. HBS semptomlarının gece daha sık
olmasından dolayı uyku kalitesinin bozukluklarına neden olabileceği düşünülmektedir.
References
- Bassetti CL, Mauerhofer D, Gugger M, Mathiss J, Hess CW. Restless legs syndrome: a clinical study of 55 patients. Eur Neurol 2001; 45: 67-74.
- Krishnan PR, Bhatia M, Behari M. Restless legs syndrome in Parkinson’s disdease: a case controlled study. Mov disord 2003; 18: 181-5.
- O’Keeffe ST. Restless legs syndrome. Arch Intern Med 1996; 156: 243-8.
- Tan EK, Ondo W. Restless legs syndrome: Clinical features and treatment. Am Med Sci 2000; 319: 397-403.
- Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, Trenkwalder C. International Restless Legs Syndrome Study Group. Validation of international restless legs syndrome study group rating scale for restless legs syndrome. Sleep med 2003; 4: 121-32.
- Desautels A, Turecki G, MontplaisirJ, Xiong L, Walters AS, Ehrenberg BL, Brisebois K, Desautels AK, Gingras Y, Johnson WG, Lugaresi E, Coccagna G, PicchiettiDL, Lazzarini A, Rouleau GA. Restless legs syndrome. Confirmation of linkage to chromosome 12q, genetic heterogeneity and evidence of complexity. Arch Neurol 2005; 62: 591-6.
- Hui DS, Wong TY, Li TS, Ko FW, Choy DK, Szeto CC, Lui SF, Li PK. Prevalence of sleep disturbances in Chinese patient with end stage renal failure on maintenance hemodialysis. Med Sci Monit 2002; 8: 331-6.
- Cirignotta F Mondini S, Santoro A, Ferrari G, Gerardi R, Buzzi G. Reliability of a questionnare screening restless legs syndrome in patients on chronic dialysis. Am. J. Kidney Dis 2002; 40: 302-6.
- Cornella CL. Restless legs syndrome: Treatment with dopamiergic agents. Neurology 2002; 58: 87-92.
- Germain A, Hall M, Krakow B, Katherine Shear M, Buysse DJ. A brief sleep scale for posttraumatic stress disorder: Pittsburgh sleep quality index addendum for PTSD. J Anxiety Disord 2005; 19: 233-44.
- Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer MA, Hopman WM. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant 2003; 18: 126-32.
- Beck SL, Schwartz AL, Towsley G, Dudley W, Barsevick A. Psychometric evaluation of the Pittsburg sleep quality index in cancer patients. J Pain Symptom Manage 2004; 27: 140-8.
- Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburg sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193-213.
- Buysse DJ, Reynolds CF, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburg Sleep Quality Index (PSQI) 1991; 14: 331-8.
- Kusleikaite N, Bumblyte IA, Rezukeviciene L, Sedlickaite D, Rinkunas K. Sleep disorder and quality of life in patients on hemodialysis. Medicina (Kaunas) 2005; 41: 69-74.
- Kamel NS, Gammack JK. Insomnia in the elderly: Cause, approach, and treatment. Am J Med 2006; 119: 463-9.
- Ohayon M. Epidemiological study on insomnia in the general population Sleep 1996; 19: 7-15.
- Walker S, Fine A, Kryger MH. Sleep complaints are common in a dialysis unit. Am J Kidney Dis 1995; 26: 751-6.
- Hui DS, Wong TY, Li TS, Ko FW, Choy DK, Szeto CC, Lui SF, Li PK. Prevalence of sleep disturbances in Chinese patients with end-stage renal failure on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 2000; 36: 783-8.
- Unruh ML, Levey AS, D'Ambrosio C, Fink NE, Powe NR, Meyer KB. Restless legs symptoms among incident dialysis patients: association with lower quality of life and shorter survival. Am J Kidney Dis 2004; 43: 900-9.
- Telarovic S, Relja M, Trkulja V. Restless legs syndrome in hemodialysis patients: Association with calcium antagonists. A preliminary report. Eur Neurol 2007; 58:166-9.
- Çölbay M, Yüksel Ş, Acartürk G, Uslan I, Karaman O. Huzursuz bacak sendromlu hemodiyaliz hastalarında uyku kalitesi: Genel Tıp Derg 2007; 17: 35- 41.
- Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S, Budai R. Restless legs syndrome in end-stage renal disease. Sleep Med 2004; 5: 309-15.
- Kim JM, Kwon HM, Lim CS, Kim YS, Lee SJ, Nam H. Restless Legs Syndrome in Patients on Hemodialysis: Symptom Severity and Risk Factors. J Clin Neurol 2008; 4: 153-7.
- Bhowmik D, Bhatia M, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Restless legs syndrome in hemodialysis patients in India: a case controlled study. Sleep Med 2003; 4: 143-6.
- Ferini-Strambi L, Aarskog D, Partinen M, Chaudhuri KR, Sohr M, Verri D, Albrecht S. Effect of pramipexole on RLS symptoms and sleep: A randomized, double-blind, placebo-controlled trial. Sleep Med 2008; 9: 874-1.
- Aksu M, Demirci S and Bara-Jimenez W. Correlation between putative indicators of primary restless legs syndrome severity. Sleep Med, 2007; 8: 84-9.
- Takaki J. Nishi T, Nangaku M, Shimoyama H, Inada T, Matsuyama N, Kumano H, Kuboki T. Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis. Am J Kidney Dis 2003; 41: 833-9.
- Collado-Seidel V, Kohnen R, Samtleben W, Hillebrand GF, Oertel WH, Trenkwalder C. Clinical and biochemical findings in uremic patients with and without restless legs syndrome. Am J Kidney Dis 1998; 31: 324-8.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | February 20, 2014 |
| Published in Issue | Year 2014 |