Research Article
Year 2020,
, 126 - 135, 20.05.2020
Abstract
References
- References
- 1. USRDS. United States Renal Data System. 2017 USRDS annual data report:epidemiology of kidney disease in the United States. Bethesda (MD): National Institutes of Health, National Institute of Diabetes and Digestive Kidney Diseases; 2017.
- 2. Sözen H, Dalgic A, Karakayali H, Baskin E, Saatci U, Arslan G, Haberal M. Renal transplantation in children. Transplant Proc 2006;38:426-9
- 3. Moudgil A, Dharnidharka VR, Lamb KE, Meier-Kriesche HU. Best allograft survival from share-35 kidney donors occurs in middle-aged adults and young children-an analysis of OPTN data. Transplantation. 2013;95(2):319-25.
- 4. Roach JP, Bock ME, Goebel J. Pediatric kidney transplantation. Seminars in Pediatric Surgery. 2017; 26 (4); 233-240
- 5. Tsai EW, Ettenger RB. Kidney Transplantation in Children. In: Danovitch GM, editor. Handbook of Kidney Transplantation. Philadelphia: Lippincott Williams & Wilkins; 2010. 355-388
- 6. Rizvi SA, Sultan S, Zafar MN, Naqvi SA, Lanewala AA, Hashmi S, Aziz T, Hassan AS, Ali B, Mohsin R, Mubarak M, Farasat S, Akhtar SF, Hashmi A, Hussain M, Hussain Z. Pediatric kidney transplantation in the developing world: Challenges and solutions. Am J Transplant 2013;13:2441-9.
- 7. Van Arendonk KJ, Boyarsky BJ, Orandi BJ, James NT, Smith JM, Colombani PM, Segev DL. National trends over 25 years in pediatric kidney transplant outcomes. Pediatrics 2014; 133:594-601.
- 8. Salvatierra O, Tanney D, Mak R. Pediatric renal transplantation and its challenges. Transplant Rev 1997;11:51-69.
- 9. Filler G, Huang SH. Progress in pediatric kidney transplantation. Ther Drug Monit 2010; 32:250-2.
- 10. The 2014 Annual Report of the North American Renal Transplant Cooperative Study. Available from: https://www.web. emmes.com/study/ped/ annlrept/annualrept2014.pdf. [Last accessed on 2017 Mar 25].
- 11. Hart A, Smith JM, Skeans MA, Gustafson SK, Stewart DE, Cherikh WS, Wainright JL, Kucheryavaya A, Woodbury M, Snyder JJ, Kasiske BL, Israni AK. OPTN/SRTR 2015 annual data report: kidney. Am J Transplant 2017;17(Suppl 1):21–116.
- 12. Magee JC, Bucuvalas JC, Farmer DG, Harmon WE, Hulbert-Shearon TE, Mendeloff EN. Pediatric transplantation. Am J Transplant. 2004;4(suppl 9):54-71.
- 13. Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2015 Annual Data Report. 2016.
- 14. Dobbels F, Van Damme-Lombaert R, Vanhaecke J, De Geest S. Growing pains: non-adherence with the immunosuppressive regimen in adolescent tran splant recipients. Pediatr Transplant. 2005;9(3):381-390.
- 15. Kroger AT, Duchin J, Vazquez M. General Best Practice Guidelines for Immunization. Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). 2017. Available at: https:// www.cdc.gov/vaccines/hcp/acip-recs/general-recs/index.html. Accessed August 20, 2017.
- 16. Srivastava A, Prabhakaran S, Sureka SK, Kapoor R, Kumar A, Sharma RK, Prasad N, Ansari MS. The challenges and outcomes of living donor kidney transplantation in pediatric and adolescent age group in a developing country: A critical analysis from a single center of North India. Indian J Urol 2015;31:33-7.
- 17. Shemesh E, Annunziato RA, Arnon R, Miloh T, Kerkar N. Adherence to medical recommendations and transition to adult services in pediatric transplant recipients. Curr Opin Organ Transplant 2010;15:288-92.
- 18. Shellmer DA, Dabbs AD, Dew MA. Medical adherence in pediatric organ transplantation: What are the next steps? Curr Opin Organ Transplant 2011;16:509-14.
- 19. Matas AJ, Smith JM, Skeans MA, et al. OPTN/SRTR 2012 annual data report: kidney. Am J Transplant 2014;14(S1):11–44.
- 20. Gargah T, Abidi K, Rajhi H, Ben Abdallah T, Chebil M, Lakhoua MR. Vascular complications after pediatric kidney transplantation. Tunis Med 2011;89:458–61.
- 21. Keller AK, Jorgensen TM, Jepersen B. Identification of risk factors for vascular thrombosis may reduce early renal graft loss: a review of recent literature. J Transplant 2012;2012:793461.
- 22. Routh JC, Yu RN, Kozinn SI, Nguyen HT, Borer JG. Urological complications and vesicoureteral reflux following pediatric kidney transplantation. J Urol 2013;189:1071–6.
- 23. Nuininga JE, Feitz WF, van Dael KC, de Gier RP, Cornelissen EA. Urologic complications in pediatric renal transplantation. Eur Urol 2001;39:598–602.
- 24. Palmer B, Kropp B. Urologic evaluation and management of pediatric kidney transplant patients Urol Clin N Am 2018;45:561-569.
- 25. Halgrimson WR, Campsen J, Mandell MS, Kelly MA, Kam I, Zimmerman MA. . Donor Complications Following Laparoscopic Compared to Hand-Assisted Living Donor Nephrectomy: An Analysis of the Literature. Journal of Transplantation. J Transplant. 2010; Article ID 825689, 10 pages.
Year 2020,
, 126 - 135, 20.05.2020
Abstract
Objective: The success rates of renal transplantation in pediatric age groups increased rapidly with the improvement of surgical technique, development of immunosuppressive drugs and the establishment of follow-up protocols specific to the pediatric age group and achieved the success rates of adult transplantation. In this study, we retrospectively analyzed the results of pediatric renal transplants performed in our center in 9 years.
Method: Between January 2010 and December 2018, 41 pediatric renal transplants were performed in our center. In our study, demographic data of donors and recipients, immunosuppressive treatment protocols applied to the recipients, post-transplant complications and renal functions of these donors were evaluated.
Results: Mean age of the recipients was 13.44 ± 3.72 and 48.8% of the recipients were female. The mean follow-up period was 46.90 ± 30.04 months. During the follow-up period, no complications due to surgery developed. One patient (2.4%) had urologic complications requiring endoscopic intervention. One patient (2.4%) had sepsis-related mortality, one patient (2.4%) had recurrence of primary disease, and three patients (7.2%) had graft loss due to medical noncompliance. The mean age was 43.15 ± 9.28 years and 53.7% of the donors were female . During the follow-up, wound-related complications were observed in two patients (4.8%). There was no change in renal function detected.
Conclusions: The results of our study show that pediatric renal transplantation was performed safely and successfully in our center when compared with the literature data published from the studies conducted in centers with high number of patients and systematic reviews.
References
- References
- 1. USRDS. United States Renal Data System. 2017 USRDS annual data report:epidemiology of kidney disease in the United States. Bethesda (MD): National Institutes of Health, National Institute of Diabetes and Digestive Kidney Diseases; 2017.
- 2. Sözen H, Dalgic A, Karakayali H, Baskin E, Saatci U, Arslan G, Haberal M. Renal transplantation in children. Transplant Proc 2006;38:426-9
- 3. Moudgil A, Dharnidharka VR, Lamb KE, Meier-Kriesche HU. Best allograft survival from share-35 kidney donors occurs in middle-aged adults and young children-an analysis of OPTN data. Transplantation. 2013;95(2):319-25.
- 4. Roach JP, Bock ME, Goebel J. Pediatric kidney transplantation. Seminars in Pediatric Surgery. 2017; 26 (4); 233-240
- 5. Tsai EW, Ettenger RB. Kidney Transplantation in Children. In: Danovitch GM, editor. Handbook of Kidney Transplantation. Philadelphia: Lippincott Williams & Wilkins; 2010. 355-388
- 6. Rizvi SA, Sultan S, Zafar MN, Naqvi SA, Lanewala AA, Hashmi S, Aziz T, Hassan AS, Ali B, Mohsin R, Mubarak M, Farasat S, Akhtar SF, Hashmi A, Hussain M, Hussain Z. Pediatric kidney transplantation in the developing world: Challenges and solutions. Am J Transplant 2013;13:2441-9.
- 7. Van Arendonk KJ, Boyarsky BJ, Orandi BJ, James NT, Smith JM, Colombani PM, Segev DL. National trends over 25 years in pediatric kidney transplant outcomes. Pediatrics 2014; 133:594-601.
- 8. Salvatierra O, Tanney D, Mak R. Pediatric renal transplantation and its challenges. Transplant Rev 1997;11:51-69.
- 9. Filler G, Huang SH. Progress in pediatric kidney transplantation. Ther Drug Monit 2010; 32:250-2.
- 10. The 2014 Annual Report of the North American Renal Transplant Cooperative Study. Available from: https://www.web. emmes.com/study/ped/ annlrept/annualrept2014.pdf. [Last accessed on 2017 Mar 25].
- 11. Hart A, Smith JM, Skeans MA, Gustafson SK, Stewart DE, Cherikh WS, Wainright JL, Kucheryavaya A, Woodbury M, Snyder JJ, Kasiske BL, Israni AK. OPTN/SRTR 2015 annual data report: kidney. Am J Transplant 2017;17(Suppl 1):21–116.
- 12. Magee JC, Bucuvalas JC, Farmer DG, Harmon WE, Hulbert-Shearon TE, Mendeloff EN. Pediatric transplantation. Am J Transplant. 2004;4(suppl 9):54-71.
- 13. Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2015 Annual Data Report. 2016.
- 14. Dobbels F, Van Damme-Lombaert R, Vanhaecke J, De Geest S. Growing pains: non-adherence with the immunosuppressive regimen in adolescent tran splant recipients. Pediatr Transplant. 2005;9(3):381-390.
- 15. Kroger AT, Duchin J, Vazquez M. General Best Practice Guidelines for Immunization. Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). 2017. Available at: https:// www.cdc.gov/vaccines/hcp/acip-recs/general-recs/index.html. Accessed August 20, 2017.
- 16. Srivastava A, Prabhakaran S, Sureka SK, Kapoor R, Kumar A, Sharma RK, Prasad N, Ansari MS. The challenges and outcomes of living donor kidney transplantation in pediatric and adolescent age group in a developing country: A critical analysis from a single center of North India. Indian J Urol 2015;31:33-7.
- 17. Shemesh E, Annunziato RA, Arnon R, Miloh T, Kerkar N. Adherence to medical recommendations and transition to adult services in pediatric transplant recipients. Curr Opin Organ Transplant 2010;15:288-92.
- 18. Shellmer DA, Dabbs AD, Dew MA. Medical adherence in pediatric organ transplantation: What are the next steps? Curr Opin Organ Transplant 2011;16:509-14.
- 19. Matas AJ, Smith JM, Skeans MA, et al. OPTN/SRTR 2012 annual data report: kidney. Am J Transplant 2014;14(S1):11–44.
- 20. Gargah T, Abidi K, Rajhi H, Ben Abdallah T, Chebil M, Lakhoua MR. Vascular complications after pediatric kidney transplantation. Tunis Med 2011;89:458–61.
- 21. Keller AK, Jorgensen TM, Jepersen B. Identification of risk factors for vascular thrombosis may reduce early renal graft loss: a review of recent literature. J Transplant 2012;2012:793461.
- 22. Routh JC, Yu RN, Kozinn SI, Nguyen HT, Borer JG. Urological complications and vesicoureteral reflux following pediatric kidney transplantation. J Urol 2013;189:1071–6.
- 23. Nuininga JE, Feitz WF, van Dael KC, de Gier RP, Cornelissen EA. Urologic complications in pediatric renal transplantation. Eur Urol 2001;39:598–602.
- 24. Palmer B, Kropp B. Urologic evaluation and management of pediatric kidney transplant patients Urol Clin N Am 2018;45:561-569.
- 25. Halgrimson WR, Campsen J, Mandell MS, Kelly MA, Kam I, Zimmerman MA. . Donor Complications Following Laparoscopic Compared to Hand-Assisted Living Donor Nephrectomy: An Analysis of the Literature. Journal of Transplantation. J Transplant. 2010; Article ID 825689, 10 pages.
There are 26 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | May 20, 2020 |
| Acceptance Date | April 7, 2020 |
| Published in Issue | Year 2020 |