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Analysis of cases diagnosed with fetal intracranial anomalies of a Tertiary Care Center

Year 2017, Volume 39, Issue 3, 597 - 601, 19.09.2017
https://doi.org/10.7197/223.v39i31705.347459

Abstract

Objective: Our aim is to evaluate the analysis of perinatal characteristics of cases diagnosed with fetal intracranial anomaly of tertiary care center over the last 10 years.

Method: A cross-sectional study of 59 pregnant women diagnosed with fetal brain anomalies between 11 and 33 weeks of gestational age (GA).  The data were collected from the archive. After that, intracranial anomalies were divided into subtypes and how often they are seen. Descriptive statistics of collected variables were calculated.

Results: 59 cases were diagnosed with an average of 19.3 ± 5.4 weeks of gestational age. Karyotype abnormality was detected in 18.6% of cases. The most common intracranial anomalies in our study were ventriculomegaly (35.6%), Arnold Chiari malformation (20.3%) and encephalocele (20.3%).

Conclusions: Despite the challenges of early gestation, accuracy in diagnosing and counseling to family for fetal brain anomalies before 24 weeks' GA was high. A multidisciplinary approach involving pediatrics, genetics, and neurosurgery, radiology, and obstetrics and gynecology departments is crucial for counseling on perinatal diagnosis. 

References

  • 1. Köşüş A, Köşüş N, Usluoğulları B, Duran M, Turhan NÖ, Tekşam M. Fetal magnetic resonance imaging in obstetric practice. J Turk Ger Gynecol Assoc 2011; 12: 39-46.
  • 2. Garcia-Flores J, Recio M, Uriel M, Cañamares M, Cruceyra M, Tamarit I, Carrascoso J, Espada M, Sáinz de la Cuesta R. Fetal magnetic resonance imaging and neurosonography in congenital neurological anomalies: supplementary diagnostic and postnatal prognostic value. J Matern Fetal Neonatal Med 2013; 26: 1517-23.
  • 3. Trudell AS, Odibo AO. Diagnosis of spina bifida on ultrasound: always termination? Best Pract Res Clin Obstet Gynaecol 2014; 28: 367-77.
  • 4. Kahn L, Mbabuike N, Valle-Giler EP, Garces J, Moore RC, Hilaire HS, Bui CJ. Fetal surgery: the ochsner experience with in utero spina bifida repair. Ochsner J 2014; 14: 112-8.
  • 5. Balakumar K. Antenatal ultrasound screening for anomalies among singletons- results of a prospective study. Calicut Medical Journal 2004; 2: 1-10
  • 6. Davies V, Gledhill J, McFadyen A, Whitlow B, Economides D. Psychological outcome in women undergoing termination of pregnancy for ultrasound-detected fetal anomaly in the first and second trimesters: a pilot study. Ultrasound Obstet Gynecol 2005; 25: 389-92.
  • 7. lknur Gümüş, Atalay Ekin, Ceren Gölbaşı, Ezgi Hürcan, Cüneyt Eftal Taner. Evaluating 101 cases with the anomaly of fetal central nervous system. Perinatal Journal 2016; 24: 136-141
  • 8. Simon EM, Goldstein RB, Coakley FV, Filly RA, Broderick KC, Musci TJ, Barkovich AJ. Fast MR imaging of fetal CNS anomalies in utero. AJNR Am J Neuroradiol 2000; 21: 1688-98.
  • 9. Emine Aydın, Mert Turgal, Sema Can, Özgür Özyüncü.Posterior fossa anomalies: related anomalies and the methods of pregnancy termination. Perinatal Journal 2016; 24: 89-95
  • 10. Griffiths PD, Bradburn M, Campbell MJ, Connolly DJA, Cooper CL, Jarvis D, Kilby MD, Mason G, Mooney C, Robson SC, Wailoo A; MERIDIAN Collaborative Group. Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort. Clin Radiol 2017; 72: 451-7.
  • 11. Molina-Giraldo S, Alfonso-Ospina L, Parra-Meza C, Lancheros-García EA, Rojas-Arias JL, Acuña-Osorio E. Prevalence in birth defects diagnosed by ultrasound: three years experience in university maternal fetal medicine unit. Ginecol Obstet Mex 2015; 83: 680-9.
  • 12. Mansouri HA. Central nervous system anomalies diagnosed antenatally and post-delivery management. Saudi Med J 2010; 31: 257-61.
  • 13. Sefidbakht S, Dehghani S, Safari M, Vafaei H, Kasraeian M. Fetal Central Nervous System Anomalies Detected by Magnetic Resonance Imaging: A Two-Year Experience. Iran J Pediatr 2016; 26: e4589.
  • 14. Ghavami M, Abedinzadeh R. Prevalence of perinatal central nervous system anomalies in East Azarbaijan-Iran. Iran J Radiol 2011; 8: 79-81.
  • 15. Wald M, Lawrenz K, Deutinger J, Weninger M. Verification of anomalies of the central nervous system detected by prenatal ultrasound. Ultraschall Med 2004; 25: 214-7.

Üçüncü basamak bir sağlık kuruluşunda fetal intrakraniyal anomali saptanan olguların analizi

Year 2017, Volume 39, Issue 3, 597 - 601, 19.09.2017
https://doi.org/10.7197/223.v39i31705.347459

Abstract

Amaç: Amacımız, son 10 yıl içerisinde, üçüncü basamakta fetal intrakranyal anomali tanısı konan olguların perinatal özelliklerinin değerlendirilmesidir.

Yöntem: Çalışma, kesitsel olarak gebelik haftası 11 ve 33 hafta arasında olan fetal beyin anomalileri saptanan 59 gebeden oluşmakta idi. Veriler arşivden toplandı. Bundan sonra intrakranyal anomaliler alt tiplere ayrılarak görülme sıklıkları belirlendi. Toplanan değişkenlerin tanımlayıcı istatistikleri hesaplandı.

Bulgular: 59 olgunun, gebelik haftasının ortalama 19.3 ± 5.4 hafta olduğu tespit edildi. Olguların% 18.sında karyotip anormalliği tespit edildi. Çalışmamızda en sık görülen intrakranyal anomaliler ventrikülomegali (% 35.6), Arnold chiari malformasyonu (% 20.3) ve ensefalosel (% 20.3) idi.

Sonuç: Erken gebelik haftasında tanının zorluklarına rağmen, gestasyonel yaşın 24 haftasından önce fetal beyin anomalilerine doğru tanı konma oranı yüksekti. Kadın Hastalıkları ve doğum, pediatri, genetik, nöroşirürji ve radyoloji bölümlerini içeren multidisipliner bir yaklaşım, perinatal teşhis için çok önemlidir.

References

  • 1. Köşüş A, Köşüş N, Usluoğulları B, Duran M, Turhan NÖ, Tekşam M. Fetal magnetic resonance imaging in obstetric practice. J Turk Ger Gynecol Assoc 2011; 12: 39-46.
  • 2. Garcia-Flores J, Recio M, Uriel M, Cañamares M, Cruceyra M, Tamarit I, Carrascoso J, Espada M, Sáinz de la Cuesta R. Fetal magnetic resonance imaging and neurosonography in congenital neurological anomalies: supplementary diagnostic and postnatal prognostic value. J Matern Fetal Neonatal Med 2013; 26: 1517-23.
  • 3. Trudell AS, Odibo AO. Diagnosis of spina bifida on ultrasound: always termination? Best Pract Res Clin Obstet Gynaecol 2014; 28: 367-77.
  • 4. Kahn L, Mbabuike N, Valle-Giler EP, Garces J, Moore RC, Hilaire HS, Bui CJ. Fetal surgery: the ochsner experience with in utero spina bifida repair. Ochsner J 2014; 14: 112-8.
  • 5. Balakumar K. Antenatal ultrasound screening for anomalies among singletons- results of a prospective study. Calicut Medical Journal 2004; 2: 1-10
  • 6. Davies V, Gledhill J, McFadyen A, Whitlow B, Economides D. Psychological outcome in women undergoing termination of pregnancy for ultrasound-detected fetal anomaly in the first and second trimesters: a pilot study. Ultrasound Obstet Gynecol 2005; 25: 389-92.
  • 7. lknur Gümüş, Atalay Ekin, Ceren Gölbaşı, Ezgi Hürcan, Cüneyt Eftal Taner. Evaluating 101 cases with the anomaly of fetal central nervous system. Perinatal Journal 2016; 24: 136-141
  • 8. Simon EM, Goldstein RB, Coakley FV, Filly RA, Broderick KC, Musci TJ, Barkovich AJ. Fast MR imaging of fetal CNS anomalies in utero. AJNR Am J Neuroradiol 2000; 21: 1688-98.
  • 9. Emine Aydın, Mert Turgal, Sema Can, Özgür Özyüncü.Posterior fossa anomalies: related anomalies and the methods of pregnancy termination. Perinatal Journal 2016; 24: 89-95
  • 10. Griffiths PD, Bradburn M, Campbell MJ, Connolly DJA, Cooper CL, Jarvis D, Kilby MD, Mason G, Mooney C, Robson SC, Wailoo A; MERIDIAN Collaborative Group. Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort. Clin Radiol 2017; 72: 451-7.
  • 11. Molina-Giraldo S, Alfonso-Ospina L, Parra-Meza C, Lancheros-García EA, Rojas-Arias JL, Acuña-Osorio E. Prevalence in birth defects diagnosed by ultrasound: three years experience in university maternal fetal medicine unit. Ginecol Obstet Mex 2015; 83: 680-9.
  • 12. Mansouri HA. Central nervous system anomalies diagnosed antenatally and post-delivery management. Saudi Med J 2010; 31: 257-61.
  • 13. Sefidbakht S, Dehghani S, Safari M, Vafaei H, Kasraeian M. Fetal Central Nervous System Anomalies Detected by Magnetic Resonance Imaging: A Two-Year Experience. Iran J Pediatr 2016; 26: e4589.
  • 14. Ghavami M, Abedinzadeh R. Prevalence of perinatal central nervous system anomalies in East Azarbaijan-Iran. Iran J Radiol 2011; 8: 79-81.
  • 15. Wald M, Lawrenz K, Deutinger J, Weninger M. Verification of anomalies of the central nervous system detected by prenatal ultrasound. Ultraschall Med 2004; 25: 214-7.

Details

Subjects Health Care Sciences and Services
Journal Section Medical Science Research Articles
Authors

Savas KARAKUS>


Serife Özlem GENC This is me


Tahsin TAKCİ This is me


Huseyin BOZKURT This is me


Begum KURT This is me


Ali CETİN This is me

Publication Date September 19, 2017
Published in Issue Year 2017, Volume 39Issue 3

Cite

APA Karakus, S. , Genc, S. Ö. , Takci, T. , Bozkurt, H. , Kurt, B. & Cetin, A. (2017). Analysis of cases diagnosed with fetal intracranial anomalies of a Tertiary Care Center . Cumhuriyet Medical Journal , 39 (3) , 597-601 . DOI: 10.7197/223.v39i31705.347459