Background: Neural tube defects (NTD) are a group of severe human
congenital malformations and complex disorders appear to be affected by
multiple factors, both genetic and environmental contributions.
Aim: To asses the frequency of NTD in Samsun province and investigate
the relationship between NTD and sociodemographic properties of families,
maternal eating habits, maternal serum folic acid, and vitamin B12 levels.
Study design: Case- control study
Method: The women who gave birth to infants with NTDs and whose pregnancies
were terminated due to having fetuses with NTDs between July 2007 and September
2008 were included in the study. The frequency of NTD was calculated from
medical records for Samsun province. Sociodemographic characteristics,
nutritional status, obstetric histories teratogen exposure and vitamin B12 and
folic acid levels of study group were compared with controls.
Results: In the study period, 63 fetuses with isolated
NTD were noted. The frequency of NTD in Samsun region was %o3,4. In the study group, family incomes,
maternal education and consumption of meat, milk, egg, cheese, vegetable, and
legumes were lower than the control group (p<0.05). Sharing of the house
with grandparents, unemployment rate, rate of febrile diseases, use of
antipyretics, exposure to radiation were higher (p<0.05). Both maternal
serum vitamin B12, folic acid in NTD group were lower than controls.
Conclusion: The frequency of NTD in Samsun region was
relatively high. NTD was more frequent in individuals with poor maternal
education, low income, and insufficient nutrition. Low serum vitamin B12 and
folic acid levels posed an increased risk for NTD. The importance of the
vitamin supplements during pregnancy is to be better appreciated by the health
authorities as well as the families.
|Subjects||Health Care Administration|
|Journal Section||Medical Science Research Articles|
|Publication Date||December 29, 2018|
|Published in Issue||Year 2018Volume: 40 Issue: 4|