Research Article
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Year 2018, Volume 40, Issue 4, 334 - 345, 29.12.2018
https://doi.org/10.7197/223.vi.498239

Abstract

References

  • Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.

DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE

Year 2018, Volume 40, Issue 4, 334 - 345, 29.12.2018
https://doi.org/10.7197/223.vi.498239

Abstract

Hypertension, defined as high blood pressure, is a common medical condition leading to cardiovascular disability and premature deaths. Blood pressure control in an efficient way are assumed to the main targets to prevent hypertension. Since conventional dosage forms (e.g. immediate release tablets, capsules, etc.) show some limitation, greater attention is being paid on designing the modified drug release systems. Modified release is defined as drug releasing from dosage form some time after the administration or in prolonged period of time. In this study, we aimed to design metoprolol tartarate loaded chitosan microparticles to obtained modified drug release. Chitosan microparticles produced via ionic gelation with tripolyphosphate as a crosslinking agent. Prepared formulations were characterized and metoprolol tartarate was loaded into the optimal blank microspheres. The entrapment efficiency, drug loading, cell viability assay and in vitro drug release were investigated. Optimum formulation was spherical and had 81% of yield and 75.373±7.384µm particle size. 16 mg of metoprolol tartarate could be loaded into microparticles and drug release could be maintained for 48 hours.

References

  • Makridakis S, DiNicolantonio JJ. Hypertension: empirical evidence and implications in 2014. Open Heart. 2014;1:e000048. doi:10.1136/openhrt-2014-000048.

Details

Primary Language English
Subjects Health Care Sciences and Services
Published Date Aralık 2018
Journal Section Basic Science Research Articles
Authors

Gülen Melike DEMIRBOLAT> (Primary Author)
CUMHURIYET UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
Türkiye


Cenk YILDIZ This is me
CUMHURIYET UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
Türkiye


Mustafa ERGÜL>
CUMHURIYET UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF BASIC PHARMACEUTICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY
Türkiye

Publication Date December 29, 2018
Published in Issue Year 2018, Volume 40Issue 4

Cite

APA Demırbolat, G. M. , Yıldız, C. & Ergül, M. (2018). DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE . Cumhuriyet Medical Journal , 40 (4) , 334-345 . DOI: 10.7197/223.vi.498239